Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol

Autores
Daier, Veronica Andrea; Moreno, Diego Martin; Duhayon, Carine; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Two MnIV complexes of general formula [Mn(salbutO)X] [H3salbutO = 1,4-bis(salicylidenamino)butan-2-ol, 1:X=N3, 2: X = SCN] have been prepared and structurally characterized. The crystal structure of 1 shows that salbutO3– acts as a pentadentate ligand through the two phenolato-O, two imino-N, and one alcoholato-O atoms, and the sixth coordination position is occupied by the azido-N atom, resulting in a slightly distorted N3O3 donor set around the MnIV ion. ESIMS, UV/Vis, and 1H NMR spectroscopy were used for solution studies. In methanol and dmf, the starting complexes are converted into [MnIII(salbutO)] and its dimeric form. The E1/2 of MnIII/MnIV (ca. 0.4 V vs. Ag/AgCl) allows this couple to efficiently catalyze the dismutation of O2 ·– with catalytic rate constant and IC50 values of 1.91 106 M–1 s–1 and 1.43 µM, respectively, which were obtained through the nitro blue tetrazolium photoreduction inhibition SOD assay, in aqueous solution of pH 7.8. The Mn-salbutO complexes also show catalase activity in methanol and dmf, with kcat = 1.6 M–2 s–1 and 5.6 M–1 s–1, respectively, an advantageous property for acting as scavenger of reactive oxygen species (ROS). This valuable conjunction of properties results from the conversion of [MnIV(salbutO)X] into [MnIII(salbutO)]2 in equilibrium with its monomer [MnIII(salbutO)].
Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Duhayon, Carine. Centre National de la Recherche Scientifique; Francia
Fil: Tuchagues, Jean Pierre. Centre National de la Recherche Scientifique; Francia
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Materia
COMPLEXES
MANGANESE
SUPEROXIDE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/280506
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/280506
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐olDaier, Veronica AndreaMoreno, Diego MartinDuhayon, CarineTuchagues, Jean PierreSignorella, Sandra RosannaCOMPLEXESMANGANESESUPEROXIDEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Two MnIV complexes of general formula [Mn(salbutO)X] [H3salbutO = 1,4-bis(salicylidenamino)butan-2-ol, 1:X=N3, 2: X = SCN] have been prepared and structurally characterized. The crystal structure of 1 shows that salbutO3– acts as a pentadentate ligand through the two phenolato-O, two imino-N, and one alcoholato-O atoms, and the sixth coordination position is occupied by the azido-N atom, resulting in a slightly distorted N3O3 donor set around the MnIV ion. ESIMS, UV/Vis, and 1H NMR spectroscopy were used for solution studies. In methanol and dmf, the starting complexes are converted into [MnIII(salbutO)] and its dimeric form. The E1/2 of MnIII/MnIV (ca. 0.4 V vs. Ag/AgCl) allows this couple to efficiently catalyze the dismutation of O2 ·– with catalytic rate constant and IC50 values of 1.91 106 M–1 s–1 and 1.43 µM, respectively, which were obtained through the nitro blue tetrazolium photoreduction inhibition SOD assay, in aqueous solution of pH 7.8. The Mn-salbutO complexes also show catalase activity in methanol and dmf, with kcat = 1.6 M–2 s–1 and 5.6 M–1 s–1, respectively, an advantageous property for acting as scavenger of reactive oxygen species (ROS). This valuable conjunction of properties results from the conversion of [MnIV(salbutO)X] into [MnIII(salbutO)]2 in equilibrium with its monomer [MnIII(salbutO)].Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Duhayon, Carine. Centre National de la Recherche Scientifique; FranciaFil: Tuchagues, Jean Pierre. Centre National de la Recherche Scientifique; FranciaFil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaWiley VCH Verlag2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/280506Daier, Veronica Andrea; Moreno, Diego Martin; Duhayon, Carine; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna; Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol; Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2010; 6; 12-2010; 965-9741434-1948CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejic.200901018info:eu-repo/semantics/altIdentifier/doi/10.1002/ejic.200901018info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-02-06T12:38:58Zoai:ri.conicet.gov.ar:11336/280506instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-02-06 12:38:58.538CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol
title Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol
spellingShingle Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol
Daier, Veronica Andrea
COMPLEXES
MANGANESE
SUPEROXIDE
title_short Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol
title_full Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol
title_fullStr Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol
title_full_unstemmed Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol
title_sort Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol
dc.creator.none.fl_str_mv Daier, Veronica Andrea
Moreno, Diego Martin
Duhayon, Carine
Tuchagues, Jean Pierre
Signorella, Sandra Rosanna
author Daier, Veronica Andrea
author_facet Daier, Veronica Andrea
Moreno, Diego Martin
Duhayon, Carine
Tuchagues, Jean Pierre
Signorella, Sandra Rosanna
author_role author
author2 Moreno, Diego Martin
Duhayon, Carine
Tuchagues, Jean Pierre
Signorella, Sandra Rosanna
author2_role author
author
author
author
dc.subject.none.fl_str_mv COMPLEXES
MANGANESE
SUPEROXIDE
topic COMPLEXES
MANGANESE
SUPEROXIDE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Two MnIV complexes of general formula [Mn(salbutO)X] [H3salbutO = 1,4-bis(salicylidenamino)butan-2-ol, 1:X=N3, 2: X = SCN] have been prepared and structurally characterized. The crystal structure of 1 shows that salbutO3– acts as a pentadentate ligand through the two phenolato-O, two imino-N, and one alcoholato-O atoms, and the sixth coordination position is occupied by the azido-N atom, resulting in a slightly distorted N3O3 donor set around the MnIV ion. ESIMS, UV/Vis, and 1H NMR spectroscopy were used for solution studies. In methanol and dmf, the starting complexes are converted into [MnIII(salbutO)] and its dimeric form. The E1/2 of MnIII/MnIV (ca. 0.4 V vs. Ag/AgCl) allows this couple to efficiently catalyze the dismutation of O2 ·– with catalytic rate constant and IC50 values of 1.91 106 M–1 s–1 and 1.43 µM, respectively, which were obtained through the nitro blue tetrazolium photoreduction inhibition SOD assay, in aqueous solution of pH 7.8. The Mn-salbutO complexes also show catalase activity in methanol and dmf, with kcat = 1.6 M–2 s–1 and 5.6 M–1 s–1, respectively, an advantageous property for acting as scavenger of reactive oxygen species (ROS). This valuable conjunction of properties results from the conversion of [MnIV(salbutO)X] into [MnIII(salbutO)]2 in equilibrium with its monomer [MnIII(salbutO)].
Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Moreno, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Duhayon, Carine. Centre National de la Recherche Scientifique; Francia
Fil: Tuchagues, Jean Pierre. Centre National de la Recherche Scientifique; Francia
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
description Two MnIV complexes of general formula [Mn(salbutO)X] [H3salbutO = 1,4-bis(salicylidenamino)butan-2-ol, 1:X=N3, 2: X = SCN] have been prepared and structurally characterized. The crystal structure of 1 shows that salbutO3– acts as a pentadentate ligand through the two phenolato-O, two imino-N, and one alcoholato-O atoms, and the sixth coordination position is occupied by the azido-N atom, resulting in a slightly distorted N3O3 donor set around the MnIV ion. ESIMS, UV/Vis, and 1H NMR spectroscopy were used for solution studies. In methanol and dmf, the starting complexes are converted into [MnIII(salbutO)] and its dimeric form. The E1/2 of MnIII/MnIV (ca. 0.4 V vs. Ag/AgCl) allows this couple to efficiently catalyze the dismutation of O2 ·– with catalytic rate constant and IC50 values of 1.91 106 M–1 s–1 and 1.43 µM, respectively, which were obtained through the nitro blue tetrazolium photoreduction inhibition SOD assay, in aqueous solution of pH 7.8. The Mn-salbutO complexes also show catalase activity in methanol and dmf, with kcat = 1.6 M–2 s–1 and 5.6 M–1 s–1, respectively, an advantageous property for acting as scavenger of reactive oxygen species (ROS). This valuable conjunction of properties results from the conversion of [MnIV(salbutO)X] into [MnIII(salbutO)]2 in equilibrium with its monomer [MnIII(salbutO)].
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/280506
Daier, Veronica Andrea; Moreno, Diego Martin; Duhayon, Carine; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna; Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol; Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2010; 6; 12-2010; 965-974
1434-1948
CONICET Digital
CONICET
url http://hdl.handle.net/11336/280506
identifier_str_mv Daier, Veronica Andrea; Moreno, Diego Martin; Duhayon, Carine; Tuchagues, Jean Pierre; Signorella, Sandra Rosanna; Synthesis, Characterization and Combined Superoxide Dismutase and Catalase Activities of Manganese Complexes of 1,4‐Bis(salicylidenamino)butan‐2‐ol; Wiley VCH Verlag; European Journal of Inorganic Chemistry; 2010; 6; 12-2010; 965-974
1434-1948
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejic.200901018
info:eu-repo/semantics/altIdentifier/doi/10.1002/ejic.200901018
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley VCH Verlag
publisher.none.fl_str_mv Wiley VCH Verlag
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.106097

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