Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls

Autores
Hernández, María Isabel; Martínez Aguayo, Alejandro; Cavada, Gabriel; Peña, Verónica; Trejo, Leon; Avila, Alejandra; Salazar, Teresa; Asenjo, Sylvia; Iñíguez, German; Rey, Rodolfo Alberto; Mericq, V.erónica
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aim: To compare pubertal development in age-matched healthy girls born with low birth weight (LBW) or appropriate birth weight for gestational age (AGA). Subjects and methods: Girls with breast in Tanner stage II and normal body mass index were followed for 3 years with a complete physical exam, bone age, pelvic ultrasound, and measurement of gonadal hormones using a leuprolide test. Results: Forty-one girls (AGA 25/LBW 16) were followed up for 3 years. By 3 years, they had similar bone age, adjusted height, and body composition. In LBW girls, breast Tanner stage advanced faster during the first 2 years of follow-up, which was associated with higher serum androgens. Hirsutism score, ovarian volume, and number of follicles between AGA and LBW were not different nor was age of menarche. By the third year, basal and poststimulated levels of gonadotropins and androgens anti-Müllerian hormone and inhibin B were similar in both groups and did not show differences related to birth weight or degree of catch-up growth. Conclusion: LBW recruits showed a slightly faster breast development but no differences in androgen excess signs, internal genitalia, and gonadal hormonal patterns.
Fil: Hernández, María Isabel. Universidad de Chile; Chile
Fil: Martínez Aguayo, Alejandro. Universidad Católica de Chile; Chile
Fil: Cavada, Gabriel. Universidad de Chile; Chile
Fil: Peña, Verónica. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; Chile
Fil: Trejo, Leon. Universidad de Chile; Chile
Fil: Avila, Alejandra. Universidad de Chile; Chile
Fil: Salazar, Teresa. Universidad de Chile; Chile
Fil: Asenjo, Sylvia. Universidad de Concepcion; Chile
Fil: Iñíguez, German. Universidad de Chile; Chile
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Mericq, V.erónica. Universidad de Chile; Chile
Materia
Amh
Birth Weight
Growth
Puberty
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/8133
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/8133
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girlsHernández, María IsabelMartínez Aguayo, AlejandroCavada, GabrielPeña, VerónicaTrejo, LeonAvila, AlejandraSalazar, TeresaAsenjo, SylviaIñíguez, GermanRey, Rodolfo AlbertoMericq, V.erónicaAmhBirth WeightGrowthPubertyhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Aim: To compare pubertal development in age-matched healthy girls born with low birth weight (LBW) or appropriate birth weight for gestational age (AGA). Subjects and methods: Girls with breast in Tanner stage II and normal body mass index were followed for 3 years with a complete physical exam, bone age, pelvic ultrasound, and measurement of gonadal hormones using a leuprolide test. Results: Forty-one girls (AGA 25/LBW 16) were followed up for 3 years. By 3 years, they had similar bone age, adjusted height, and body composition. In LBW girls, breast Tanner stage advanced faster during the first 2 years of follow-up, which was associated with higher serum androgens. Hirsutism score, ovarian volume, and number of follicles between AGA and LBW were not different nor was age of menarche. By the third year, basal and poststimulated levels of gonadotropins and androgens anti-Müllerian hormone and inhibin B were similar in both groups and did not show differences related to birth weight or degree of catch-up growth. Conclusion: LBW recruits showed a slightly faster breast development but no differences in androgen excess signs, internal genitalia, and gonadal hormonal patterns.Fil: Hernández, María Isabel. Universidad de Chile; ChileFil: Martínez Aguayo, Alejandro. Universidad Católica de Chile; ChileFil: Cavada, Gabriel. Universidad de Chile; ChileFil: Peña, Verónica. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; ChileFil: Trejo, Leon. Universidad de Chile; ChileFil: Avila, Alejandra. Universidad de Chile; ChileFil: Salazar, Teresa. Universidad de Chile; ChileFil: Asenjo, Sylvia. Universidad de Concepcion; ChileFil: Iñíguez, German. Universidad de Chile; ChileFil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; ArgentinaFil: Mericq, V.erónica. Universidad de Chile; ChileDe Gruyter2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/8133Hernández, María Isabel; Martínez Aguayo, Alejandro; Cavada, Gabriel; Peña, Verónica; Trejo, Leon; et al.; Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls; De Gruyter; Journal Of Pediatric Endocrinology And Metabolism; 26; 3-4; 4-2013; 223-2302191-0251enginfo:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/jpem.2013.26.issue-3-4/jpem-2012-0345/jpem-2012-0345.xmlinfo:eu-repo/semantics/altIdentifier/doi/10.1515/jpem-2012-0345info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:02Zoai:ri.conicet.gov.ar:11336/8133instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:02.475CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
title Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
spellingShingle Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
Hernández, María Isabel
Amh
Birth Weight
Growth
Puberty
title_short Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
title_full Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
title_fullStr Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
title_full_unstemmed Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
title_sort Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls
dc.creator.none.fl_str_mv Hernández, María Isabel
Martínez Aguayo, Alejandro
Cavada, Gabriel
Peña, Verónica
Trejo, Leon
Avila, Alejandra
Salazar, Teresa
Asenjo, Sylvia
Iñíguez, German
Rey, Rodolfo Alberto
Mericq, V.erónica
author Hernández, María Isabel
author_facet Hernández, María Isabel
Martínez Aguayo, Alejandro
Cavada, Gabriel
Peña, Verónica
Trejo, Leon
Avila, Alejandra
Salazar, Teresa
Asenjo, Sylvia
Iñíguez, German
Rey, Rodolfo Alberto
Mericq, V.erónica
author_role author
author2 Martínez Aguayo, Alejandro
Cavada, Gabriel
Peña, Verónica
Trejo, Leon
Avila, Alejandra
Salazar, Teresa
Asenjo, Sylvia
Iñíguez, German
Rey, Rodolfo Alberto
Mericq, V.erónica
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Amh
Birth Weight
Growth
Puberty
topic Amh
Birth Weight
Growth
Puberty
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aim: To compare pubertal development in age-matched healthy girls born with low birth weight (LBW) or appropriate birth weight for gestational age (AGA). Subjects and methods: Girls with breast in Tanner stage II and normal body mass index were followed for 3 years with a complete physical exam, bone age, pelvic ultrasound, and measurement of gonadal hormones using a leuprolide test. Results: Forty-one girls (AGA 25/LBW 16) were followed up for 3 years. By 3 years, they had similar bone age, adjusted height, and body composition. In LBW girls, breast Tanner stage advanced faster during the first 2 years of follow-up, which was associated with higher serum androgens. Hirsutism score, ovarian volume, and number of follicles between AGA and LBW were not different nor was age of menarche. By the third year, basal and poststimulated levels of gonadotropins and androgens anti-Müllerian hormone and inhibin B were similar in both groups and did not show differences related to birth weight or degree of catch-up growth. Conclusion: LBW recruits showed a slightly faster breast development but no differences in androgen excess signs, internal genitalia, and gonadal hormonal patterns.
Fil: Hernández, María Isabel. Universidad de Chile; Chile
Fil: Martínez Aguayo, Alejandro. Universidad Católica de Chile; Chile
Fil: Cavada, Gabriel. Universidad de Chile; Chile
Fil: Peña, Verónica. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; Chile
Fil: Trejo, Leon. Universidad de Chile; Chile
Fil: Avila, Alejandra. Universidad de Chile; Chile
Fil: Salazar, Teresa. Universidad de Chile; Chile
Fil: Asenjo, Sylvia. Universidad de Concepcion; Chile
Fil: Iñíguez, German. Universidad de Chile; Chile
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
Fil: Mericq, V.erónica. Universidad de Chile; Chile
description Aim: To compare pubertal development in age-matched healthy girls born with low birth weight (LBW) or appropriate birth weight for gestational age (AGA). Subjects and methods: Girls with breast in Tanner stage II and normal body mass index were followed for 3 years with a complete physical exam, bone age, pelvic ultrasound, and measurement of gonadal hormones using a leuprolide test. Results: Forty-one girls (AGA 25/LBW 16) were followed up for 3 years. By 3 years, they had similar bone age, adjusted height, and body composition. In LBW girls, breast Tanner stage advanced faster during the first 2 years of follow-up, which was associated with higher serum androgens. Hirsutism score, ovarian volume, and number of follicles between AGA and LBW were not different nor was age of menarche. By the third year, basal and poststimulated levels of gonadotropins and androgens anti-Müllerian hormone and inhibin B were similar in both groups and did not show differences related to birth weight or degree of catch-up growth. Conclusion: LBW recruits showed a slightly faster breast development but no differences in androgen excess signs, internal genitalia, and gonadal hormonal patterns.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/8133
Hernández, María Isabel; Martínez Aguayo, Alejandro; Cavada, Gabriel; Peña, Verónica; Trejo, Leon; et al.; Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls; De Gruyter; Journal Of Pediatric Endocrinology And Metabolism; 26; 3-4; 4-2013; 223-230
2191-0251
url http://hdl.handle.net/11336/8133
identifier_str_mv Hernández, María Isabel; Martínez Aguayo, Alejandro; Cavada, Gabriel; Peña, Verónica; Trejo, Leon; et al.; Accelerated early pubertal progression, ovarian morphology, and ovarian function in prospectively followed low birth weight (LBW) girls; De Gruyter; Journal Of Pediatric Endocrinology And Metabolism; 26; 3-4; 4-2013; 223-230
2191-0251
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/jpem.2013.26.issue-3-4/jpem-2012-0345/jpem-2012-0345.xml
info:eu-repo/semantics/altIdentifier/doi/10.1515/jpem-2012-0345
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270066936119296
score 13.13397

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