Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood

Autores
Desplats, Paula; Gutierrez, Ashley M.; Antonelli, Marta Cristina; Frasch, Martin G.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process. The key elements of this phenomenon are chronic stress, neuroinflammation triggering microglial polarization, microglial memory and their connection to neurodegeneration. We review the mediating mechanisms which may function as early biomarkers of increased susceptibility for neurodegeneration. Can we devise novel early life modifying interventions to steer developmental trajectories to their optimum?.
Fil: Desplats, Paula. University of California; Estados Unidos
Fil: Gutierrez, Ashley M.. University of California; Estados Unidos
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Frasch, Martin G.. University of Washington; Estados Unidos
Materia
ALZHEIMER'S
ANIMAL MODELS
CHRNA7
EARLY LIFE
ENRICHED ENVIRONMENT
GLIA
NEUROINFLAMMATION
PARKINSON'S
POLICY
PREGNANCY STRESS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130322
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthoodDesplats, PaulaGutierrez, Ashley M.Antonelli, Marta CristinaFrasch, Martin G.ALZHEIMER'SANIMAL MODELSCHRNA7EARLY LIFEENRICHED ENVIRONMENTGLIANEUROINFLAMMATIONPARKINSON'SPOLICYPREGNANCY STRESShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process. The key elements of this phenomenon are chronic stress, neuroinflammation triggering microglial polarization, microglial memory and their connection to neurodegeneration. We review the mediating mechanisms which may function as early biomarkers of increased susceptibility for neurodegeneration. Can we devise novel early life modifying interventions to steer developmental trajectories to their optimum?.Fil: Desplats, Paula. University of California; Estados UnidosFil: Gutierrez, Ashley M.. University of California; Estados UnidosFil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Frasch, Martin G.. University of Washington; Estados UnidosPergamon-Elsevier Science Ltd2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130322Desplats, Paula; Gutierrez, Ashley M.; Antonelli, Marta Cristina; Frasch, Martin G.; Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood; Pergamon-Elsevier Science Ltd; Neuroscience and Biobehavioral Reviews; 117; 11-2019; 232-2420149-7634CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0149763418309734info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neubiorev.2019.10.013info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:23:40Zoai:ri.conicet.gov.ar:11336/130322instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:23:41.273CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
title Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
spellingShingle Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
Desplats, Paula
ALZHEIMER'S
ANIMAL MODELS
CHRNA7
EARLY LIFE
ENRICHED ENVIRONMENT
GLIA
NEUROINFLAMMATION
PARKINSON'S
POLICY
PREGNANCY STRESS
title_short Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
title_full Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
title_fullStr Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
title_full_unstemmed Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
title_sort Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood
dc.creator.none.fl_str_mv Desplats, Paula
Gutierrez, Ashley M.
Antonelli, Marta Cristina
Frasch, Martin G.
author Desplats, Paula
author_facet Desplats, Paula
Gutierrez, Ashley M.
Antonelli, Marta Cristina
Frasch, Martin G.
author_role author
author2 Gutierrez, Ashley M.
Antonelli, Marta Cristina
Frasch, Martin G.
author2_role author
author
author
dc.subject.none.fl_str_mv ALZHEIMER'S
ANIMAL MODELS
CHRNA7
EARLY LIFE
ENRICHED ENVIRONMENT
GLIA
NEUROINFLAMMATION
PARKINSON'S
POLICY
PREGNANCY STRESS
topic ALZHEIMER'S
ANIMAL MODELS
CHRNA7
EARLY LIFE
ENRICHED ENVIRONMENT
GLIA
NEUROINFLAMMATION
PARKINSON'S
POLICY
PREGNANCY STRESS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process. The key elements of this phenomenon are chronic stress, neuroinflammation triggering microglial polarization, microglial memory and their connection to neurodegeneration. We review the mediating mechanisms which may function as early biomarkers of increased susceptibility for neurodegeneration. Can we devise novel early life modifying interventions to steer developmental trajectories to their optimum?.
Fil: Desplats, Paula. University of California; Estados Unidos
Fil: Gutierrez, Ashley M.. University of California; Estados Unidos
Fil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Frasch, Martin G.. University of Washington; Estados Unidos
description We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process. The key elements of this phenomenon are chronic stress, neuroinflammation triggering microglial polarization, microglial memory and their connection to neurodegeneration. We review the mediating mechanisms which may function as early biomarkers of increased susceptibility for neurodegeneration. Can we devise novel early life modifying interventions to steer developmental trajectories to their optimum?.
publishDate 2019
dc.date.none.fl_str_mv 2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130322
Desplats, Paula; Gutierrez, Ashley M.; Antonelli, Marta Cristina; Frasch, Martin G.; Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood; Pergamon-Elsevier Science Ltd; Neuroscience and Biobehavioral Reviews; 117; 11-2019; 232-242
0149-7634
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130322
identifier_str_mv Desplats, Paula; Gutierrez, Ashley M.; Antonelli, Marta Cristina; Frasch, Martin G.; Microglial memory of early life stress and inflammation: Susceptibility to neurodegeneration in adulthood; Pergamon-Elsevier Science Ltd; Neuroscience and Biobehavioral Reviews; 117; 11-2019; 232-242
0149-7634
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0149763418309734
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neubiorev.2019.10.013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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