Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate

Autores
Ceschan, Nazareth Eliana; Balbi, María Cecilia; Ravazzoli, Pablo Damián; Drazer, German; Muzzio, Fernando Javier; Callegari, Gerardo Carlos
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution, porosity and content uniformity, were measured to determine granule characteristics. The set of experiments was based on a central composite design face-centered. Granules in both systems showed drug content consistent with expected values across varying process parameters. Relative granules size, normalized with the granulator gap, was larger for the equipment with the smaller gap. The liquid-to-solid ratio (LSR) was the most influential parameter affecting the granule size. Specifically, dimensional granule size increased with LSR values in both systems, consistent with previous studies. Elevated LSR values resulted in greater amounts of over-granulated material, whereas lower values produced exceedingly small (fines) or under-granulated material. The minimum amounts of both over- and undergranulated material were found at intermediate LSR values. Porosity varied differently between the systems, with a consistent reduction observed as LSR decreased from 0.3 to 0.4. Optimization studies revealed that central values of LSR and screw speed minimized fines and bigger granules while maximizing porosity, critical attributes for downstream processing. Granule size and porosity exhibited no significant correlation with tablet tensile strength across both systems. These findings offer valuable insights for optimizing pharmaceutical manufacturing processes to enhance product quality.
Fil: Ceschan, Nazareth Eliana. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Balbi, María Cecilia. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ravazzoli, Pablo Damián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Tandil. Sede Tandil del Centro de Investigaciones En Fisica E Ingenieria del Centro de la Provincia de Buenos Aires.; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Instituto de Física Arroyo Seco; Argentina
Fil: Drazer, German. Rutgers University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Muzzio, Fernando Javier. The State University of New Jersey; Estados Unidos
Fil: Callegari, Gerardo Carlos. Rutgers University. School of Engineering. Chemical and Biochemical Engineering Department; Estados Unidos. The State University of New Jersey; Estados Unidos
Materia
TWIN SCREW GRANULATOR
GRANULE PROPERTIES
OPTIMIZATION
TABLETABILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/274126
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/274126
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rateCeschan, Nazareth ElianaBalbi, María CeciliaRavazzoli, Pablo DamiánDrazer, GermanMuzzio, Fernando JavierCallegari, Gerardo CarlosTWIN SCREW GRANULATORGRANULE PROPERTIESOPTIMIZATIONTABLETABILITYhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution, porosity and content uniformity, were measured to determine granule characteristics. The set of experiments was based on a central composite design face-centered. Granules in both systems showed drug content consistent with expected values across varying process parameters. Relative granules size, normalized with the granulator gap, was larger for the equipment with the smaller gap. The liquid-to-solid ratio (LSR) was the most influential parameter affecting the granule size. Specifically, dimensional granule size increased with LSR values in both systems, consistent with previous studies. Elevated LSR values resulted in greater amounts of over-granulated material, whereas lower values produced exceedingly small (fines) or under-granulated material. The minimum amounts of both over- and undergranulated material were found at intermediate LSR values. Porosity varied differently between the systems, with a consistent reduction observed as LSR decreased from 0.3 to 0.4. Optimization studies revealed that central values of LSR and screw speed minimized fines and bigger granules while maximizing porosity, critical attributes for downstream processing. Granule size and porosity exhibited no significant correlation with tablet tensile strength across both systems. These findings offer valuable insights for optimizing pharmaceutical manufacturing processes to enhance product quality.Fil: Ceschan, Nazareth Eliana. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Balbi, María Cecilia. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ravazzoli, Pablo Damián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Tandil. Sede Tandil del Centro de Investigaciones En Fisica E Ingenieria del Centro de la Provincia de Buenos Aires.; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Instituto de Física Arroyo Seco; ArgentinaFil: Drazer, German. Rutgers University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Muzzio, Fernando Javier. The State University of New Jersey; Estados UnidosFil: Callegari, Gerardo Carlos. Rutgers University. School of Engineering. Chemical and Biochemical Engineering Department; Estados Unidos. The State University of New Jersey; Estados UnidosElsevier Science SA2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/274126Ceschan, Nazareth Eliana; Balbi, María Cecilia; Ravazzoli, Pablo Damián; Drazer, German; Muzzio, Fernando Javier; et al.; Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate; Elsevier Science SA; Powder Technology; 462; 121092; 5-2025; 1-350032-5910CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0032591025004875info:eu-repo/semantics/altIdentifier/doi/10.1016/j.powtec.2025.121092info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-05T09:36:17Zoai:ri.conicet.gov.ar:11336/274126instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-05 09:36:17.629CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate
title Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate
spellingShingle Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate
Ceschan, Nazareth Eliana
TWIN SCREW GRANULATOR
GRANULE PROPERTIES
OPTIMIZATION
TABLETABILITY
title_short Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate
title_full Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate
title_fullStr Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate
title_full_unstemmed Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate
title_sort Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate
dc.creator.none.fl_str_mv Ceschan, Nazareth Eliana
Balbi, María Cecilia
Ravazzoli, Pablo Damián
Drazer, German
Muzzio, Fernando Javier
Callegari, Gerardo Carlos
author Ceschan, Nazareth Eliana
author_facet Ceschan, Nazareth Eliana
Balbi, María Cecilia
Ravazzoli, Pablo Damián
Drazer, German
Muzzio, Fernando Javier
Callegari, Gerardo Carlos
author_role author
author2 Balbi, María Cecilia
Ravazzoli, Pablo Damián
Drazer, German
Muzzio, Fernando Javier
Callegari, Gerardo Carlos
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv TWIN SCREW GRANULATOR
GRANULE PROPERTIES
OPTIMIZATION
TABLETABILITY
topic TWIN SCREW GRANULATOR
GRANULE PROPERTIES
OPTIMIZATION
TABLETABILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution, porosity and content uniformity, were measured to determine granule characteristics. The set of experiments was based on a central composite design face-centered. Granules in both systems showed drug content consistent with expected values across varying process parameters. Relative granules size, normalized with the granulator gap, was larger for the equipment with the smaller gap. The liquid-to-solid ratio (LSR) was the most influential parameter affecting the granule size. Specifically, dimensional granule size increased with LSR values in both systems, consistent with previous studies. Elevated LSR values resulted in greater amounts of over-granulated material, whereas lower values produced exceedingly small (fines) or under-granulated material. The minimum amounts of both over- and undergranulated material were found at intermediate LSR values. Porosity varied differently between the systems, with a consistent reduction observed as LSR decreased from 0.3 to 0.4. Optimization studies revealed that central values of LSR and screw speed minimized fines and bigger granules while maximizing porosity, critical attributes for downstream processing. Granule size and porosity exhibited no significant correlation with tablet tensile strength across both systems. These findings offer valuable insights for optimizing pharmaceutical manufacturing processes to enhance product quality.
Fil: Ceschan, Nazareth Eliana. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Balbi, María Cecilia. Universidad Nacional del Litoral; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ravazzoli, Pablo Damián. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Tandil. Sede Tandil del Centro de Investigaciones En Fisica E Ingenieria del Centro de la Provincia de Buenos Aires.; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Instituto de Física Arroyo Seco; Argentina
Fil: Drazer, German. Rutgers University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Muzzio, Fernando Javier. The State University of New Jersey; Estados Unidos
Fil: Callegari, Gerardo Carlos. Rutgers University. School of Engineering. Chemical and Biochemical Engineering Department; Estados Unidos. The State University of New Jersey; Estados Unidos
description We study the response of two twin-screw granulators of different barrel diameter to the variation of three process parameters (liquid-to-solid ratio, screw speed and throughput), while maintaining the same shear rate field along the screws. Various responses, including size distribution, porosity and content uniformity, were measured to determine granule characteristics. The set of experiments was based on a central composite design face-centered. Granules in both systems showed drug content consistent with expected values across varying process parameters. Relative granules size, normalized with the granulator gap, was larger for the equipment with the smaller gap. The liquid-to-solid ratio (LSR) was the most influential parameter affecting the granule size. Specifically, dimensional granule size increased with LSR values in both systems, consistent with previous studies. Elevated LSR values resulted in greater amounts of over-granulated material, whereas lower values produced exceedingly small (fines) or under-granulated material. The minimum amounts of both over- and undergranulated material were found at intermediate LSR values. Porosity varied differently between the systems, with a consistent reduction observed as LSR decreased from 0.3 to 0.4. Optimization studies revealed that central values of LSR and screw speed minimized fines and bigger granules while maximizing porosity, critical attributes for downstream processing. Granule size and porosity exhibited no significant correlation with tablet tensile strength across both systems. These findings offer valuable insights for optimizing pharmaceutical manufacturing processes to enhance product quality.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/274126
Ceschan, Nazareth Eliana; Balbi, María Cecilia; Ravazzoli, Pablo Damián; Drazer, German; Muzzio, Fernando Javier; et al.; Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate; Elsevier Science SA; Powder Technology; 462; 121092; 5-2025; 1-35
0032-5910
CONICET Digital
CONICET
url http://hdl.handle.net/11336/274126
identifier_str_mv Ceschan, Nazareth Eliana; Balbi, María Cecilia; Ravazzoli, Pablo Damián; Drazer, German; Muzzio, Fernando Javier; et al.; Comparison of granules obtained with two twin-screw granulators of different diameter working at the same shear rate; Elsevier Science SA; Powder Technology; 462; 121092; 5-2025; 1-35
0032-5910
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0032591025004875
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.powtec.2025.121092
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science SA
publisher.none.fl_str_mv Elsevier Science SA
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.121305

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