A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia
- Autores
- Blois, Sandra M.; Dechend, Ralf; Barrientos, Gabriela Laura; Staff, Anne Catherine
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This review discusses a potential role of galectins and the renin-angiotensin system (RAS) in the pathophysiology of preeclampsia (PE). Preeclampsia affects between 3 and 5 % of all pregnancies and is a heterogeneous disease, which may be caused by multiple factors. The only cure is the delivery of the placenta, which may result in a premature delivery and baby. Probably due to its heterogeneity, PE studies in human have hitherto only led to the identification of a limited number of factors involved in the pathogenesis of the disease. Animal models, particularly in mice and rats, have been used to gain further insight into the molecular pathology behind PE. In this review, we discuss the picture emerging from human and animal studies pointing to galectins and the RAS being associated with the PE syndrome and affecting a broad range of cellular signaling components. Moreover, we review the epidemiological evidence for PE increasing the risk of future cardiovascular disease later in life.
Fil: Blois, Sandra M.. Universität zu Berlin; Alemania
Fil: Dechend, Ralf. Charité-Campus Buch-Max-Delbrück Center for Molecular Medicine. Experimental and Clinical Research Center; Alemania
Fil: Barrientos, Gabriela Laura. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Staff, Anne Catherine. University of Oslo; Noruega - Materia
-
Acute Atherosis
Galectins
Preeclampsia
Renin-Angiotensin System - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/37525
Ver los metadatos del registro completo
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A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsiaBlois, Sandra M.Dechend, RalfBarrientos, Gabriela LauraStaff, Anne CatherineAcute AtherosisGalectinsPreeclampsiaRenin-Angiotensin Systemhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This review discusses a potential role of galectins and the renin-angiotensin system (RAS) in the pathophysiology of preeclampsia (PE). Preeclampsia affects between 3 and 5 % of all pregnancies and is a heterogeneous disease, which may be caused by multiple factors. The only cure is the delivery of the placenta, which may result in a premature delivery and baby. Probably due to its heterogeneity, PE studies in human have hitherto only led to the identification of a limited number of factors involved in the pathogenesis of the disease. Animal models, particularly in mice and rats, have been used to gain further insight into the molecular pathology behind PE. In this review, we discuss the picture emerging from human and animal studies pointing to galectins and the RAS being associated with the PE syndrome and affecting a broad range of cellular signaling components. Moreover, we review the epidemiological evidence for PE increasing the risk of future cardiovascular disease later in life.Fil: Blois, Sandra M.. Universität zu Berlin; AlemaniaFil: Dechend, Ralf. Charité-Campus Buch-Max-Delbrück Center for Molecular Medicine. Experimental and Clinical Research Center; AlemaniaFil: Barrientos, Gabriela Laura. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Staff, Anne Catherine. University of Oslo; NoruegaSpringer2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37525Blois, Sandra M.; Dechend, Ralf; Barrientos, Gabriela Laura; Staff, Anne Catherine; A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia; Springer; Cellular and Molecular Life Sciences; 72; 1; 1-2015; 39-501420-682X1420-9071CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00018-014-1713-1info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-014-1713-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:03Zoai:ri.conicet.gov.ar:11336/37525instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:03.314CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia |
title |
A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia |
spellingShingle |
A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia Blois, Sandra M. Acute Atherosis Galectins Preeclampsia Renin-Angiotensin System |
title_short |
A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia |
title_full |
A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia |
title_fullStr |
A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia |
title_full_unstemmed |
A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia |
title_sort |
A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia |
dc.creator.none.fl_str_mv |
Blois, Sandra M. Dechend, Ralf Barrientos, Gabriela Laura Staff, Anne Catherine |
author |
Blois, Sandra M. |
author_facet |
Blois, Sandra M. Dechend, Ralf Barrientos, Gabriela Laura Staff, Anne Catherine |
author_role |
author |
author2 |
Dechend, Ralf Barrientos, Gabriela Laura Staff, Anne Catherine |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Acute Atherosis Galectins Preeclampsia Renin-Angiotensin System |
topic |
Acute Atherosis Galectins Preeclampsia Renin-Angiotensin System |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
This review discusses a potential role of galectins and the renin-angiotensin system (RAS) in the pathophysiology of preeclampsia (PE). Preeclampsia affects between 3 and 5 % of all pregnancies and is a heterogeneous disease, which may be caused by multiple factors. The only cure is the delivery of the placenta, which may result in a premature delivery and baby. Probably due to its heterogeneity, PE studies in human have hitherto only led to the identification of a limited number of factors involved in the pathogenesis of the disease. Animal models, particularly in mice and rats, have been used to gain further insight into the molecular pathology behind PE. In this review, we discuss the picture emerging from human and animal studies pointing to galectins and the RAS being associated with the PE syndrome and affecting a broad range of cellular signaling components. Moreover, we review the epidemiological evidence for PE increasing the risk of future cardiovascular disease later in life. Fil: Blois, Sandra M.. Universität zu Berlin; Alemania Fil: Dechend, Ralf. Charité-Campus Buch-Max-Delbrück Center for Molecular Medicine. Experimental and Clinical Research Center; Alemania Fil: Barrientos, Gabriela Laura. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Staff, Anne Catherine. University of Oslo; Noruega |
description |
This review discusses a potential role of galectins and the renin-angiotensin system (RAS) in the pathophysiology of preeclampsia (PE). Preeclampsia affects between 3 and 5 % of all pregnancies and is a heterogeneous disease, which may be caused by multiple factors. The only cure is the delivery of the placenta, which may result in a premature delivery and baby. Probably due to its heterogeneity, PE studies in human have hitherto only led to the identification of a limited number of factors involved in the pathogenesis of the disease. Animal models, particularly in mice and rats, have been used to gain further insight into the molecular pathology behind PE. In this review, we discuss the picture emerging from human and animal studies pointing to galectins and the RAS being associated with the PE syndrome and affecting a broad range of cellular signaling components. Moreover, we review the epidemiological evidence for PE increasing the risk of future cardiovascular disease later in life. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/37525 Blois, Sandra M.; Dechend, Ralf; Barrientos, Gabriela Laura; Staff, Anne Catherine; A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia; Springer; Cellular and Molecular Life Sciences; 72; 1; 1-2015; 39-50 1420-682X 1420-9071 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/37525 |
identifier_str_mv |
Blois, Sandra M.; Dechend, Ralf; Barrientos, Gabriela Laura; Staff, Anne Catherine; A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia; Springer; Cellular and Molecular Life Sciences; 72; 1; 1-2015; 39-50 1420-682X 1420-9071 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00018-014-1713-1 info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-014-1713-1 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
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Springer |
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Springer |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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