A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia

Autores
Blois, Sandra M.; Dechend, Ralf; Barrientos, Gabriela Laura; Staff, Anne Catherine
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review discusses a potential role of galectins and the renin-angiotensin system (RAS) in the pathophysiology of preeclampsia (PE). Preeclampsia affects between 3 and 5 % of all pregnancies and is a heterogeneous disease, which may be caused by multiple factors. The only cure is the delivery of the placenta, which may result in a premature delivery and baby. Probably due to its heterogeneity, PE studies in human have hitherto only led to the identification of a limited number of factors involved in the pathogenesis of the disease. Animal models, particularly in mice and rats, have been used to gain further insight into the molecular pathology behind PE. In this review, we discuss the picture emerging from human and animal studies pointing to galectins and the RAS being associated with the PE syndrome and affecting a broad range of cellular signaling components. Moreover, we review the epidemiological evidence for PE increasing the risk of future cardiovascular disease later in life.
Fil: Blois, Sandra M.. Universität zu Berlin; Alemania
Fil: Dechend, Ralf. Charité-Campus Buch-Max-Delbrück Center for Molecular Medicine. Experimental and Clinical Research Center; Alemania
Fil: Barrientos, Gabriela Laura. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Staff, Anne Catherine. University of Oslo; Noruega
Materia
Acute Atherosis
Galectins
Preeclampsia
Renin-Angiotensin System
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/37525
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsiaBlois, Sandra M.Dechend, RalfBarrientos, Gabriela LauraStaff, Anne CatherineAcute AtherosisGalectinsPreeclampsiaRenin-Angiotensin Systemhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This review discusses a potential role of galectins and the renin-angiotensin system (RAS) in the pathophysiology of preeclampsia (PE). Preeclampsia affects between 3 and 5 % of all pregnancies and is a heterogeneous disease, which may be caused by multiple factors. The only cure is the delivery of the placenta, which may result in a premature delivery and baby. Probably due to its heterogeneity, PE studies in human have hitherto only led to the identification of a limited number of factors involved in the pathogenesis of the disease. Animal models, particularly in mice and rats, have been used to gain further insight into the molecular pathology behind PE. In this review, we discuss the picture emerging from human and animal studies pointing to galectins and the RAS being associated with the PE syndrome and affecting a broad range of cellular signaling components. Moreover, we review the epidemiological evidence for PE increasing the risk of future cardiovascular disease later in life.Fil: Blois, Sandra M.. Universität zu Berlin; AlemaniaFil: Dechend, Ralf. Charité-Campus Buch-Max-Delbrück Center for Molecular Medicine. Experimental and Clinical Research Center; AlemaniaFil: Barrientos, Gabriela Laura. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Staff, Anne Catherine. University of Oslo; NoruegaSpringer2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37525Blois, Sandra M.; Dechend, Ralf; Barrientos, Gabriela Laura; Staff, Anne Catherine; A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia; Springer; Cellular and Molecular Life Sciences; 72; 1; 1-2015; 39-501420-682X1420-9071CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00018-014-1713-1info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-014-1713-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:25:21Zoai:ri.conicet.gov.ar:11336/37525instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:25:21.793CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia
title A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia
spellingShingle A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia
Blois, Sandra M.
Acute Atherosis
Galectins
Preeclampsia
Renin-Angiotensin System
title_short A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia
title_full A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia
title_fullStr A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia
title_full_unstemmed A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia
title_sort A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia
dc.creator.none.fl_str_mv Blois, Sandra M.
Dechend, Ralf
Barrientos, Gabriela Laura
Staff, Anne Catherine
author Blois, Sandra M.
author_facet Blois, Sandra M.
Dechend, Ralf
Barrientos, Gabriela Laura
Staff, Anne Catherine
author_role author
author2 Dechend, Ralf
Barrientos, Gabriela Laura
Staff, Anne Catherine
author2_role author
author
author
dc.subject.none.fl_str_mv Acute Atherosis
Galectins
Preeclampsia
Renin-Angiotensin System
topic Acute Atherosis
Galectins
Preeclampsia
Renin-Angiotensin System
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This review discusses a potential role of galectins and the renin-angiotensin system (RAS) in the pathophysiology of preeclampsia (PE). Preeclampsia affects between 3 and 5 % of all pregnancies and is a heterogeneous disease, which may be caused by multiple factors. The only cure is the delivery of the placenta, which may result in a premature delivery and baby. Probably due to its heterogeneity, PE studies in human have hitherto only led to the identification of a limited number of factors involved in the pathogenesis of the disease. Animal models, particularly in mice and rats, have been used to gain further insight into the molecular pathology behind PE. In this review, we discuss the picture emerging from human and animal studies pointing to galectins and the RAS being associated with the PE syndrome and affecting a broad range of cellular signaling components. Moreover, we review the epidemiological evidence for PE increasing the risk of future cardiovascular disease later in life.
Fil: Blois, Sandra M.. Universität zu Berlin; Alemania
Fil: Dechend, Ralf. Charité-Campus Buch-Max-Delbrück Center for Molecular Medicine. Experimental and Clinical Research Center; Alemania
Fil: Barrientos, Gabriela Laura. Hospital Alemán. Laboratorio de Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Staff, Anne Catherine. University of Oslo; Noruega
description This review discusses a potential role of galectins and the renin-angiotensin system (RAS) in the pathophysiology of preeclampsia (PE). Preeclampsia affects between 3 and 5 % of all pregnancies and is a heterogeneous disease, which may be caused by multiple factors. The only cure is the delivery of the placenta, which may result in a premature delivery and baby. Probably due to its heterogeneity, PE studies in human have hitherto only led to the identification of a limited number of factors involved in the pathogenesis of the disease. Animal models, particularly in mice and rats, have been used to gain further insight into the molecular pathology behind PE. In this review, we discuss the picture emerging from human and animal studies pointing to galectins and the RAS being associated with the PE syndrome and affecting a broad range of cellular signaling components. Moreover, we review the epidemiological evidence for PE increasing the risk of future cardiovascular disease later in life.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/37525
Blois, Sandra M.; Dechend, Ralf; Barrientos, Gabriela Laura; Staff, Anne Catherine; A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia; Springer; Cellular and Molecular Life Sciences; 72; 1; 1-2015; 39-50
1420-682X
1420-9071
CONICET Digital
CONICET
url http://hdl.handle.net/11336/37525
identifier_str_mv Blois, Sandra M.; Dechend, Ralf; Barrientos, Gabriela Laura; Staff, Anne Catherine; A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia; Springer; Cellular and Molecular Life Sciences; 72; 1; 1-2015; 39-50
1420-682X
1420-9071
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00018-014-1713-1
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00018-014-1713-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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