Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?

Autores
Toneatto, Judith; Charó, Nancy Lorena; Naselli, Agostina; Muñoz Bernart, Melina; Lombardi, Antonella; Piwien Pilipuk, Graciela
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is well known that glucocorticoids and mineralocorticoids are part of the list of hormones that control adipogenesis as well as different aspects of the physiology of the adipose tissue. Their actions are mediated through their binding to the glucocorticoid and the mineralocorticoid receptors (GR and MR, respectively), in complex with heat shock proteins (Hsps) and high molecular weight immunophilins (IMMs). Albeit many aspects of the molecular mechanism of the corticosteroid receptors are not fully elucidated yet, it was not until recently that the first evidences of the functional importance of Hsps and IMMs in the process of adipocyte differentiation have been described. Hsp90 and the high molecular weight IMM FKBP51 modulate GR and MR activity at multiple levels, that is, hormone binding affinity, their subcellular distribution, and the transcriptional status, among other aspects of the NR function. Interestingly, it has recently been described that Hsp90 and FKBP51 also participate in the control of PPARγ, a key transcription factor in the control of adipogenesis and the maintenance of the adipocyte phenotype. In addition, novel roles have been uncovered for FKBP51 in the organization of the nuclear architecture through its participation in the reorganization of the nuclear lamina and the control of the subnuclear distribution of GR. Thus, the aim of this review is to integrate and discuss the actual understanding of the role of corticosteroid receptors, their chaperones and cochaperones, in the process of adipocyte differentiation.
Fil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Charó, Nancy Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Naselli, Agostina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Muñoz Bernart, Melina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Lombardi, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Piwien Pilipuk, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Materia
ADIPOGENESIS
GLUCOCORTICOID RECEPTOR
MINERALOCORTICOID RECEPTOR
FKBP51
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6576
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6576
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?Toneatto, JudithCharó, Nancy LorenaNaselli, AgostinaMuñoz Bernart, MelinaLombardi, AntonellaPiwien Pilipuk, GracielaADIPOGENESISGLUCOCORTICOID RECEPTORMINERALOCORTICOID RECEPTORFKBP51https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1It is well known that glucocorticoids and mineralocorticoids are part of the list of hormones that control adipogenesis as well as different aspects of the physiology of the adipose tissue. Their actions are mediated through their binding to the glucocorticoid and the mineralocorticoid receptors (GR and MR, respectively), in complex with heat shock proteins (Hsps) and high molecular weight immunophilins (IMMs). Albeit many aspects of the molecular mechanism of the corticosteroid receptors are not fully elucidated yet, it was not until recently that the first evidences of the functional importance of Hsps and IMMs in the process of adipocyte differentiation have been described. Hsp90 and the high molecular weight IMM FKBP51 modulate GR and MR activity at multiple levels, that is, hormone binding affinity, their subcellular distribution, and the transcriptional status, among other aspects of the NR function. Interestingly, it has recently been described that Hsp90 and FKBP51 also participate in the control of PPARγ, a key transcription factor in the control of adipogenesis and the maintenance of the adipocyte phenotype. In addition, novel roles have been uncovered for FKBP51 in the organization of the nuclear architecture through its participation in the reorganization of the nuclear lamina and the control of the subnuclear distribution of GR. Thus, the aim of this review is to integrate and discuss the actual understanding of the role of corticosteroid receptors, their chaperones and cochaperones, in the process of adipocyte differentiation.Fil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Charó, Nancy Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Naselli, Agostina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Muñoz Bernart, Melina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Lombardi, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Piwien Pilipuk, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaAgial Publishing House2014-10-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6576Toneatto, Judith; Charó, Nancy Lorena; Naselli, Agostina; Muñoz Bernart, Melina; Lombardi, Antonella; et al.; Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?; Agial Publishing House; Nuclear Receptor Research; 1; 5-10-2014; 1-172314-57062314-5714enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/url/http://www.agialpress.com/journals/nurr/2014/101092/info:eu-repo/semantics/altIdentifier/doi/10.11131/2014/101092info:eu-repo/semantics/altIdentifier/url/https://doaj.org/article/22c47279e4e547ffbcaa9deaae4f4fc5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:06Zoai:ri.conicet.gov.ar:11336/6576instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:06.93CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?
title Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?
spellingShingle Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?
Toneatto, Judith
ADIPOGENESIS
GLUCOCORTICOID RECEPTOR
MINERALOCORTICOID RECEPTOR
FKBP51
title_short Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?
title_full Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?
title_fullStr Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?
title_full_unstemmed Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?
title_sort Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?
dc.creator.none.fl_str_mv Toneatto, Judith
Charó, Nancy Lorena
Naselli, Agostina
Muñoz Bernart, Melina
Lombardi, Antonella
Piwien Pilipuk, Graciela
author Toneatto, Judith
author_facet Toneatto, Judith
Charó, Nancy Lorena
Naselli, Agostina
Muñoz Bernart, Melina
Lombardi, Antonella
Piwien Pilipuk, Graciela
author_role author
author2 Charó, Nancy Lorena
Naselli, Agostina
Muñoz Bernart, Melina
Lombardi, Antonella
Piwien Pilipuk, Graciela
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ADIPOGENESIS
GLUCOCORTICOID RECEPTOR
MINERALOCORTICOID RECEPTOR
FKBP51
topic ADIPOGENESIS
GLUCOCORTICOID RECEPTOR
MINERALOCORTICOID RECEPTOR
FKBP51
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv It is well known that glucocorticoids and mineralocorticoids are part of the list of hormones that control adipogenesis as well as different aspects of the physiology of the adipose tissue. Their actions are mediated through their binding to the glucocorticoid and the mineralocorticoid receptors (GR and MR, respectively), in complex with heat shock proteins (Hsps) and high molecular weight immunophilins (IMMs). Albeit many aspects of the molecular mechanism of the corticosteroid receptors are not fully elucidated yet, it was not until recently that the first evidences of the functional importance of Hsps and IMMs in the process of adipocyte differentiation have been described. Hsp90 and the high molecular weight IMM FKBP51 modulate GR and MR activity at multiple levels, that is, hormone binding affinity, their subcellular distribution, and the transcriptional status, among other aspects of the NR function. Interestingly, it has recently been described that Hsp90 and FKBP51 also participate in the control of PPARγ, a key transcription factor in the control of adipogenesis and the maintenance of the adipocyte phenotype. In addition, novel roles have been uncovered for FKBP51 in the organization of the nuclear architecture through its participation in the reorganization of the nuclear lamina and the control of the subnuclear distribution of GR. Thus, the aim of this review is to integrate and discuss the actual understanding of the role of corticosteroid receptors, their chaperones and cochaperones, in the process of adipocyte differentiation.
Fil: Toneatto, Judith. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Charó, Nancy Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Naselli, Agostina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Muñoz Bernart, Melina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Lombardi, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Piwien Pilipuk, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
description It is well known that glucocorticoids and mineralocorticoids are part of the list of hormones that control adipogenesis as well as different aspects of the physiology of the adipose tissue. Their actions are mediated through their binding to the glucocorticoid and the mineralocorticoid receptors (GR and MR, respectively), in complex with heat shock proteins (Hsps) and high molecular weight immunophilins (IMMs). Albeit many aspects of the molecular mechanism of the corticosteroid receptors are not fully elucidated yet, it was not until recently that the first evidences of the functional importance of Hsps and IMMs in the process of adipocyte differentiation have been described. Hsp90 and the high molecular weight IMM FKBP51 modulate GR and MR activity at multiple levels, that is, hormone binding affinity, their subcellular distribution, and the transcriptional status, among other aspects of the NR function. Interestingly, it has recently been described that Hsp90 and FKBP51 also participate in the control of PPARγ, a key transcription factor in the control of adipogenesis and the maintenance of the adipocyte phenotype. In addition, novel roles have been uncovered for FKBP51 in the organization of the nuclear architecture through its participation in the reorganization of the nuclear lamina and the control of the subnuclear distribution of GR. Thus, the aim of this review is to integrate and discuss the actual understanding of the role of corticosteroid receptors, their chaperones and cochaperones, in the process of adipocyte differentiation.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6576
Toneatto, Judith; Charó, Nancy Lorena; Naselli, Agostina; Muñoz Bernart, Melina; Lombardi, Antonella; et al.; Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?; Agial Publishing House; Nuclear Receptor Research; 1; 5-10-2014; 1-17
2314-5706
2314-5714
url http://hdl.handle.net/11336/6576
identifier_str_mv Toneatto, Judith; Charó, Nancy Lorena; Naselli, Agostina; Muñoz Bernart, Melina; Lombardi, Antonella; et al.; Corticosteroid receptors, their chaperones and co-chaperones: How do they modulate adipogenesis?; Agial Publishing House; Nuclear Receptor Research; 1; 5-10-2014; 1-17
2314-5706
2314-5714
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/url/http://www.agialpress.com/journals/nurr/2014/101092/
info:eu-repo/semantics/altIdentifier/doi/10.11131/2014/101092
info:eu-repo/semantics/altIdentifier/url/https://doaj.org/article/22c47279e4e547ffbcaa9deaae4f4fc5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Agial Publishing House
publisher.none.fl_str_mv Agial Publishing House
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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