Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease

Autores
Morfini, Gerardo Andres; Schmidt, Nadine; Weissmann, Carina; Pigino, Gustavo Fernando; Kins, Stefan
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Intracellular trafficking events powered by microtubule-based molecular motors facilitate the targeted delivery of selected molecular components to specific neuronal subdomains. Within this context, we provide a brief review of mechanisms underlying the execution of axonal transport (AT) by conventional kinesin, the most abundant kinesin-related motor protein in the mature nervous system. We emphasize the biochemical heterogeneity of this multi-subunit motor protein, further discussing its significance in light of recent discoveries revealing its regulation by various protein kinases. In addition, we raise issues relevant to the mode of conventional kinesin attachment to cargoes and examine recent evidence linking alterations in conventional kinesin phosphorylation to the pathogenesis of adult-onset neurodegenerative diseases.
Fil: Morfini, Gerardo Andres. University of Illinois; Estados Unidos
Fil: Schmidt, Nadine. University of Kaiserslautern; Alemania
Fil: Weissmann, Carina. University of Illinois; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Pigino, Gustavo Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. University of Kaiserslautern; Alemania
Fil: Kins, Stefan. University of Kaiserslautern; Alemania
Materia
Axonal Transport
Kif5
Kinesin
Kinesin-1
Klc
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/61501
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Conventional kinesin: Biochemical heterogeneity and functional implications in health and diseaseMorfini, Gerardo AndresSchmidt, NadineWeissmann, CarinaPigino, Gustavo FernandoKins, StefanAxonal TransportKif5KinesinKinesin-1Klchttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Intracellular trafficking events powered by microtubule-based molecular motors facilitate the targeted delivery of selected molecular components to specific neuronal subdomains. Within this context, we provide a brief review of mechanisms underlying the execution of axonal transport (AT) by conventional kinesin, the most abundant kinesin-related motor protein in the mature nervous system. We emphasize the biochemical heterogeneity of this multi-subunit motor protein, further discussing its significance in light of recent discoveries revealing its regulation by various protein kinases. In addition, we raise issues relevant to the mode of conventional kinesin attachment to cargoes and examine recent evidence linking alterations in conventional kinesin phosphorylation to the pathogenesis of adult-onset neurodegenerative diseases.Fil: Morfini, Gerardo Andres. University of Illinois; Estados UnidosFil: Schmidt, Nadine. University of Kaiserslautern; AlemaniaFil: Weissmann, Carina. University of Illinois; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Pigino, Gustavo Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. University of Kaiserslautern; AlemaniaFil: Kins, Stefan. University of Kaiserslautern; AlemaniaPergamon-Elsevier Science Ltd2016-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/61501Morfini, Gerardo Andres; Schmidt, Nadine; Weissmann, Carina; Pigino, Gustavo Fernando; Kins, Stefan; Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 126; 9-2016; 347-3530361-9230CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.brainresbull.2016.06.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0361923016301332info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:44Zoai:ri.conicet.gov.ar:11336/61501instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:44.64CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
title Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
spellingShingle Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
Morfini, Gerardo Andres
Axonal Transport
Kif5
Kinesin
Kinesin-1
Klc
title_short Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
title_full Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
title_fullStr Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
title_full_unstemmed Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
title_sort Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
dc.creator.none.fl_str_mv Morfini, Gerardo Andres
Schmidt, Nadine
Weissmann, Carina
Pigino, Gustavo Fernando
Kins, Stefan
author Morfini, Gerardo Andres
author_facet Morfini, Gerardo Andres
Schmidt, Nadine
Weissmann, Carina
Pigino, Gustavo Fernando
Kins, Stefan
author_role author
author2 Schmidt, Nadine
Weissmann, Carina
Pigino, Gustavo Fernando
Kins, Stefan
author2_role author
author
author
author
dc.subject.none.fl_str_mv Axonal Transport
Kif5
Kinesin
Kinesin-1
Klc
topic Axonal Transport
Kif5
Kinesin
Kinesin-1
Klc
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Intracellular trafficking events powered by microtubule-based molecular motors facilitate the targeted delivery of selected molecular components to specific neuronal subdomains. Within this context, we provide a brief review of mechanisms underlying the execution of axonal transport (AT) by conventional kinesin, the most abundant kinesin-related motor protein in the mature nervous system. We emphasize the biochemical heterogeneity of this multi-subunit motor protein, further discussing its significance in light of recent discoveries revealing its regulation by various protein kinases. In addition, we raise issues relevant to the mode of conventional kinesin attachment to cargoes and examine recent evidence linking alterations in conventional kinesin phosphorylation to the pathogenesis of adult-onset neurodegenerative diseases.
Fil: Morfini, Gerardo Andres. University of Illinois; Estados Unidos
Fil: Schmidt, Nadine. University of Kaiserslautern; Alemania
Fil: Weissmann, Carina. University of Illinois; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Pigino, Gustavo Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. University of Kaiserslautern; Alemania
Fil: Kins, Stefan. University of Kaiserslautern; Alemania
description Intracellular trafficking events powered by microtubule-based molecular motors facilitate the targeted delivery of selected molecular components to specific neuronal subdomains. Within this context, we provide a brief review of mechanisms underlying the execution of axonal transport (AT) by conventional kinesin, the most abundant kinesin-related motor protein in the mature nervous system. We emphasize the biochemical heterogeneity of this multi-subunit motor protein, further discussing its significance in light of recent discoveries revealing its regulation by various protein kinases. In addition, we raise issues relevant to the mode of conventional kinesin attachment to cargoes and examine recent evidence linking alterations in conventional kinesin phosphorylation to the pathogenesis of adult-onset neurodegenerative diseases.
publishDate 2016
dc.date.none.fl_str_mv 2016-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/61501
Morfini, Gerardo Andres; Schmidt, Nadine; Weissmann, Carina; Pigino, Gustavo Fernando; Kins, Stefan; Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 126; 9-2016; 347-353
0361-9230
CONICET Digital
CONICET
url http://hdl.handle.net/11336/61501
identifier_str_mv Morfini, Gerardo Andres; Schmidt, Nadine; Weissmann, Carina; Pigino, Gustavo Fernando; Kins, Stefan; Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 126; 9-2016; 347-353
0361-9230
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.brainresbull.2016.06.009
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0361923016301332
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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