Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor

Autores
Houshmandi, S.S.; Surace, Ezequiel Ignacio; Zhang, H.B.; Fuller, G.N.; Gutmann, D.H.
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tumor suppressor in lung cancer-1 (TSLC1) loss is common in many human cancers, including meningioma. In this study, we demonstrate that TSLC1 protein and RNA expression is lost in 60% to 65% of high-grade gliomas, and that TSLC1 reintroduction into glioma cells results in growth suppression. Moreover, Tslc1 loss in mice results in increased astrocyte proliferation in vivo and in vitro. These data indicate that TSLC1 functions as a glioma tumor suppressor. ©2006AAN Enterprises, Inc.
Fil: Houshmandi, S.S.. Washington University in St. Louis; Estados Unidos
Fil: Surace, Ezequiel Ignacio. Washington University in St. Louis; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Zhang, H.B.. Washington University in St. Louis; Estados Unidos
Fil: Fuller, G.N.. University of Texas; Estados Unidos
Fil: Gutmann, D.H.. Washington University in St. Louis; Estados Unidos
Materia
Lung Cancer
Tumor Suppressor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39064
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressorHoushmandi, S.S.Surace, Ezequiel IgnacioZhang, H.B.Fuller, G.N.Gutmann, D.H.Lung CancerTumor Suppressorhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Tumor suppressor in lung cancer-1 (TSLC1) loss is common in many human cancers, including meningioma. In this study, we demonstrate that TSLC1 protein and RNA expression is lost in 60% to 65% of high-grade gliomas, and that TSLC1 reintroduction into glioma cells results in growth suppression. Moreover, Tslc1 loss in mice results in increased astrocyte proliferation in vivo and in vitro. These data indicate that TSLC1 functions as a glioma tumor suppressor. ©2006AAN Enterprises, Inc.Fil: Houshmandi, S.S.. Washington University in St. Louis; Estados UnidosFil: Surace, Ezequiel Ignacio. Washington University in St. Louis; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Zhang, H.B.. Washington University in St. Louis; Estados UnidosFil: Fuller, G.N.. University of Texas; Estados UnidosFil: Gutmann, D.H.. Washington University in St. Louis; Estados UnidosLippincott Williams2006-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39064Houshmandi, S.S.; Surace, Ezequiel Ignacio; Zhang, H.B.; Fuller, G.N.; Gutmann, D.H.; Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor; Lippincott Williams; Neurology; 67; 10; 11-2006; 1863-18660028-38781526-632XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://n.neurology.org/content/67/10/1863.longinfo:eu-repo/semantics/altIdentifier/doi/10.1212/01.wnl.0000244472.56198.84info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:36Zoai:ri.conicet.gov.ar:11336/39064instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:36.748CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor
title Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor
spellingShingle Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor
Houshmandi, S.S.
Lung Cancer
Tumor Suppressor
title_short Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor
title_full Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor
title_fullStr Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor
title_full_unstemmed Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor
title_sort Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor
dc.creator.none.fl_str_mv Houshmandi, S.S.
Surace, Ezequiel Ignacio
Zhang, H.B.
Fuller, G.N.
Gutmann, D.H.
author Houshmandi, S.S.
author_facet Houshmandi, S.S.
Surace, Ezequiel Ignacio
Zhang, H.B.
Fuller, G.N.
Gutmann, D.H.
author_role author
author2 Surace, Ezequiel Ignacio
Zhang, H.B.
Fuller, G.N.
Gutmann, D.H.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Lung Cancer
Tumor Suppressor
topic Lung Cancer
Tumor Suppressor
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Tumor suppressor in lung cancer-1 (TSLC1) loss is common in many human cancers, including meningioma. In this study, we demonstrate that TSLC1 protein and RNA expression is lost in 60% to 65% of high-grade gliomas, and that TSLC1 reintroduction into glioma cells results in growth suppression. Moreover, Tslc1 loss in mice results in increased astrocyte proliferation in vivo and in vitro. These data indicate that TSLC1 functions as a glioma tumor suppressor. ©2006AAN Enterprises, Inc.
Fil: Houshmandi, S.S.. Washington University in St. Louis; Estados Unidos
Fil: Surace, Ezequiel Ignacio. Washington University in St. Louis; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Zhang, H.B.. Washington University in St. Louis; Estados Unidos
Fil: Fuller, G.N.. University of Texas; Estados Unidos
Fil: Gutmann, D.H.. Washington University in St. Louis; Estados Unidos
description Tumor suppressor in lung cancer-1 (TSLC1) loss is common in many human cancers, including meningioma. In this study, we demonstrate that TSLC1 protein and RNA expression is lost in 60% to 65% of high-grade gliomas, and that TSLC1 reintroduction into glioma cells results in growth suppression. Moreover, Tslc1 loss in mice results in increased astrocyte proliferation in vivo and in vitro. These data indicate that TSLC1 functions as a glioma tumor suppressor. ©2006AAN Enterprises, Inc.
publishDate 2006
dc.date.none.fl_str_mv 2006-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39064
Houshmandi, S.S.; Surace, Ezequiel Ignacio; Zhang, H.B.; Fuller, G.N.; Gutmann, D.H.; Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor; Lippincott Williams; Neurology; 67; 10; 11-2006; 1863-1866
0028-3878
1526-632X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39064
identifier_str_mv Houshmandi, S.S.; Surace, Ezequiel Ignacio; Zhang, H.B.; Fuller, G.N.; Gutmann, D.H.; Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor; Lippincott Williams; Neurology; 67; 10; 11-2006; 1863-1866
0028-3878
1526-632X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://n.neurology.org/content/67/10/1863.long
info:eu-repo/semantics/altIdentifier/doi/10.1212/01.wnl.0000244472.56198.84
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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