Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance

Autores
Napoli, Marco; Girardini Brovelli, Javier Enrique; Del Sal, Giannino
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
During the last decade, the role of p53 point mutants as determinants of tumor aggressiveness was conclusively demonstrated.1 Based on a large body of evidence, a more complete picture on the consequences of p53 mutation in human cancer is emerging, where a single missense mutation transforms one of the most efficient tumor suppressor pathways into a powerful network promoting tumor progression. Indeed, these mutant p53 proteins are devoid of oncosuppressive abilities while, on the contrary, acquire novel oncogenic properties supporting several tumorigenic processes like cell proliferation, death resistance, genomic instability, angiogenesis and metastasis formation.
Fil: Napoli, Marco. Università degli Studi di Trieste; Italia
Fil: Girardini Brovelli, Javier Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Del Sal, Giannino. Università degli Studi di Trieste; Italia
Materia
PLK2
Cancer
Chemoresistance
Mutant p53
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/269004
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/269004
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistanceNapoli, MarcoGirardini Brovelli, Javier EnriqueDel Sal, GianninoPLK2CancerChemoresistanceMutant p53https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1During the last decade, the role of p53 point mutants as determinants of tumor aggressiveness was conclusively demonstrated.1 Based on a large body of evidence, a more complete picture on the consequences of p53 mutation in human cancer is emerging, where a single missense mutation transforms one of the most efficient tumor suppressor pathways into a powerful network promoting tumor progression. Indeed, these mutant p53 proteins are devoid of oncosuppressive abilities while, on the contrary, acquire novel oncogenic properties supporting several tumorigenic processes like cell proliferation, death resistance, genomic instability, angiogenesis and metastasis formation.Fil: Napoli, Marco. Università degli Studi di Trieste; ItaliaFil: Girardini Brovelli, Javier Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Del Sal, Giannino. Università degli Studi di Trieste; ItaliaLandes Bioscience2012-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269004Napoli, Marco; Girardini Brovelli, Javier Enrique; Del Sal, Giannino; Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance; Landes Bioscience; Cell Cycle; 11; 3; 2-2012; 438-4381538-4101CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.4161/cc.11.3.19225info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:14:21Zoai:ri.conicet.gov.ar:11336/269004instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:14:22.27CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance
title Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance
spellingShingle Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance
Napoli, Marco
PLK2
Cancer
Chemoresistance
Mutant p53
title_short Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance
title_full Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance
title_fullStr Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance
title_full_unstemmed Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance
title_sort Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance
dc.creator.none.fl_str_mv Napoli, Marco
Girardini Brovelli, Javier Enrique
Del Sal, Giannino
author Napoli, Marco
author_facet Napoli, Marco
Girardini Brovelli, Javier Enrique
Del Sal, Giannino
author_role author
author2 Girardini Brovelli, Javier Enrique
Del Sal, Giannino
author2_role author
author
dc.subject.none.fl_str_mv PLK2
Cancer
Chemoresistance
Mutant p53
topic PLK2
Cancer
Chemoresistance
Mutant p53
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv During the last decade, the role of p53 point mutants as determinants of tumor aggressiveness was conclusively demonstrated.1 Based on a large body of evidence, a more complete picture on the consequences of p53 mutation in human cancer is emerging, where a single missense mutation transforms one of the most efficient tumor suppressor pathways into a powerful network promoting tumor progression. Indeed, these mutant p53 proteins are devoid of oncosuppressive abilities while, on the contrary, acquire novel oncogenic properties supporting several tumorigenic processes like cell proliferation, death resistance, genomic instability, angiogenesis and metastasis formation.
Fil: Napoli, Marco. Università degli Studi di Trieste; Italia
Fil: Girardini Brovelli, Javier Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Del Sal, Giannino. Università degli Studi di Trieste; Italia
description During the last decade, the role of p53 point mutants as determinants of tumor aggressiveness was conclusively demonstrated.1 Based on a large body of evidence, a more complete picture on the consequences of p53 mutation in human cancer is emerging, where a single missense mutation transforms one of the most efficient tumor suppressor pathways into a powerful network promoting tumor progression. Indeed, these mutant p53 proteins are devoid of oncosuppressive abilities while, on the contrary, acquire novel oncogenic properties supporting several tumorigenic processes like cell proliferation, death resistance, genomic instability, angiogenesis and metastasis formation.
publishDate 2012
dc.date.none.fl_str_mv 2012-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/269004
Napoli, Marco; Girardini Brovelli, Javier Enrique; Del Sal, Giannino; Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance; Landes Bioscience; Cell Cycle; 11; 3; 2-2012; 438-438
1538-4101
CONICET Digital
CONICET
url http://hdl.handle.net/11336/269004
identifier_str_mv Napoli, Marco; Girardini Brovelli, Javier Enrique; Del Sal, Giannino; Polo-like kinase 2: A new exploitable target to undermine mutant p53-dependent chemoresistance; Landes Bioscience; Cell Cycle; 11; 3; 2-2012; 438-438
1538-4101
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.4161/cc.11.3.19225
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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