Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction
- Autores
- Alzamendi, Ana; Giovambattista, Andres; Garcia, Maria Elisa; Rebolledo, Oscar Remigio; Gagliardino, Juan Jose; Spinedi, Eduardo Julio
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Aim: To test the potential role of PPAR in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology: Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25 mg/Kg BW/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin. Results: Plasma glucose, insulin, triglyceride, TBARS, LEP and PAI-1 levels were higher in FRD rats; PIO co-administration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin receptor substrate (IRS)-1 and IRS-2 were reduced. PIO co-administration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully), and IRS-1 (partially) mRNAs in AAT. Conclusion: PPARγ would play a relevant role in the development of the FRD-induced metabolic-endocrine dysfunction.
Fil: Alzamendi, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Giovambattista, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Garcia, Maria Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
Fil: Rebolledo, Oscar Remigio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina
Fil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina - Materia
-
PPARg
Abdominal Adiposity
Insulin Sensitivity
Experimental Metabolic Syndrome - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/270766
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Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue DysfunctionAlzamendi, AnaGiovambattista, AndresGarcia, Maria ElisaRebolledo, Oscar RemigioGagliardino, Juan JoseSpinedi, Eduardo JulioPPARgAbdominal AdiposityInsulin SensitivityExperimental Metabolic Syndromehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aim: To test the potential role of PPAR in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology: Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25 mg/Kg BW/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin. Results: Plasma glucose, insulin, triglyceride, TBARS, LEP and PAI-1 levels were higher in FRD rats; PIO co-administration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin receptor substrate (IRS)-1 and IRS-2 were reduced. PIO co-administration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully), and IRS-1 (partially) mRNAs in AAT. Conclusion: PPARγ would play a relevant role in the development of the FRD-induced metabolic-endocrine dysfunction.Fil: Alzamendi, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Giovambattista, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Garcia, Maria Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Rebolledo, Oscar Remigio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; ArgentinaFil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaHindawi Publishing Corporation2012-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/270766Alzamendi, Ana; Giovambattista, Andres; Garcia, Maria Elisa; Rebolledo, Oscar Remigio; Gagliardino, Juan Jose; et al.; Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction; Hindawi Publishing Corporation; PPAR Research; 2012; 8-2012; 1-91687-47571687-4765CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1155/2012/259093info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/259093info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:40Zoai:ri.conicet.gov.ar:11336/270766instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:41.099CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction |
title |
Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction |
spellingShingle |
Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction Alzamendi, Ana PPARg Abdominal Adiposity Insulin Sensitivity Experimental Metabolic Syndrome |
title_short |
Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction |
title_full |
Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction |
title_fullStr |
Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction |
title_full_unstemmed |
Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction |
title_sort |
Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction |
dc.creator.none.fl_str_mv |
Alzamendi, Ana Giovambattista, Andres Garcia, Maria Elisa Rebolledo, Oscar Remigio Gagliardino, Juan Jose Spinedi, Eduardo Julio |
author |
Alzamendi, Ana |
author_facet |
Alzamendi, Ana Giovambattista, Andres Garcia, Maria Elisa Rebolledo, Oscar Remigio Gagliardino, Juan Jose Spinedi, Eduardo Julio |
author_role |
author |
author2 |
Giovambattista, Andres Garcia, Maria Elisa Rebolledo, Oscar Remigio Gagliardino, Juan Jose Spinedi, Eduardo Julio |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
PPARg Abdominal Adiposity Insulin Sensitivity Experimental Metabolic Syndrome |
topic |
PPARg Abdominal Adiposity Insulin Sensitivity Experimental Metabolic Syndrome |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Aim: To test the potential role of PPAR in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology: Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25 mg/Kg BW/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin. Results: Plasma glucose, insulin, triglyceride, TBARS, LEP and PAI-1 levels were higher in FRD rats; PIO co-administration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin receptor substrate (IRS)-1 and IRS-2 were reduced. PIO co-administration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully), and IRS-1 (partially) mRNAs in AAT. Conclusion: PPARγ would play a relevant role in the development of the FRD-induced metabolic-endocrine dysfunction. Fil: Alzamendi, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Giovambattista, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina Fil: Garcia, Maria Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina Fil: Rebolledo, Oscar Remigio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina Fil: Gagliardino, Juan Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Endocrinología Experimental y Aplicada. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Endocrinología Experimental y Aplicada; Argentina Fil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina |
description |
Aim: To test the potential role of PPAR in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology: Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25 mg/Kg BW/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin. Results: Plasma glucose, insulin, triglyceride, TBARS, LEP and PAI-1 levels were higher in FRD rats; PIO co-administration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin receptor substrate (IRS)-1 and IRS-2 were reduced. PIO co-administration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully), and IRS-1 (partially) mRNAs in AAT. Conclusion: PPARγ would play a relevant role in the development of the FRD-induced metabolic-endocrine dysfunction. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/270766 Alzamendi, Ana; Giovambattista, Andres; Garcia, Maria Elisa; Rebolledo, Oscar Remigio; Gagliardino, Juan Jose; et al.; Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction; Hindawi Publishing Corporation; PPAR Research; 2012; 8-2012; 1-9 1687-4757 1687-4765 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/270766 |
identifier_str_mv |
Alzamendi, Ana; Giovambattista, Andres; Garcia, Maria Elisa; Rebolledo, Oscar Remigio; Gagliardino, Juan Jose; et al.; Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction; Hindawi Publishing Corporation; PPAR Research; 2012; 8-2012; 1-9 1687-4757 1687-4765 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1155/2012/259093 info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/259093 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |