Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model

Autores
Márquez, María Antonela; Russo, Matias Irineo; Andrada, Lidia Estefania; Medina, Roxana Beatriz; Gauffin Cano, María Paola
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The use of nutritional therapies with functional foods has a promising application for metabolic disorders, such as diet-induced obesity (DIO). The objective of this work was to evaluate in mice with DIO, the administration of fermented goat milk (FGM) with Lactobacillus (L.) delbrueckii subsp. bulgaricus CRL1447 and supplemented with different mixes of Lactobacillus strains, on metabolic and immunologic parameters. The strain mixtures (Mix) were formed as follow: Mix 1: L. fermentum CRL1446, L. plantarum CRL1449 and CRL1472 strains, Mix 2: CRL1446 and CRL1449, Mix 3: CRL1446 and CRL1472 and Mix 4: CRL1449 and CRL1472. Seven groups (n = 6) of male C57BL/6 mice were used: Control groups: 1) Standard diet (SD) group: SD + water, 2) FGM group: SD + FGM; 3) Obese (Ob)+FGM group: high fat diet (HFD) + FGM; Obese groups with treatments: 4) Ob+FGM+Mix1 group: HFD + FGM + Mix1, 5) Ob+FGM+Mix2 group: HFD + FGM + Mix2, 6) Ob+FGM+Mix3 group: HFD + FGM + Mix3, 7) Ob+FGM+Mix4 group: HFD + FGM + Mix4. After 10 weeks of feeding, following determinations were made in plasma: glucose and lipid profile by enzymatic methods, leptin by ELISA and cytokines by CBA. Body weight gain (BWG) was evaluated weekly. The results were compared with Ob+FMG group. BWG decreased 34% and 22% in Ob+FGM+Mix2 and Ob+FGM+Mix3 group (respectively). Triglyceride and leptin levels in Ob+FGM+Mix2 group were significantly reduced (35% and 22%, respectively). Regarding total and LDL cholesterol, no significant differences were observed in the different treatment groups. HDL-cholesterol values increased 22% in FGM+Mix 2 and 19% in FGM+Mix3. Levels of glucose values decreased in groups fed with FGM+Mix2 (48%) and FGM+Mix3 (43%). The administration of supplementated FGM with Mix2 reduce levels of pro-inflammatory cytokines (MCP-1 and IL-6), while no significant differences were observed in levels of anti-inflammatory cytokine IL-10. In conclusion, we suggest the use of FGM supplemented with Mix2 as a supplement to nutritional therapies due to its hypotriglyceridemic, hypoglycemic and immunomodulatory properties.
Fil: Márquez, María Antonela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Andrada, Lidia Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Medina, Roxana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina
Fil: Gauffin Cano, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
LVI Annual Meeting Argentine Society for Biochemistry and Molecular Biology; XV Annual Meeting Argentinean Society for General Microbiology
Mendoza
Argentina
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Sociedad Argentina de Microbiología General
Materia
LACTOBACILLUS
FERMENTED GOAT MILK
OBESITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/193422
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/193422
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine modelMárquez, María AntonelaRusso, Matias IrineoAndrada, Lidia EstefaniaMedina, Roxana BeatrizGauffin Cano, María PaolaLACTOBACILLUSFERMENTED GOAT MILKOBESITYhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3The use of nutritional therapies with functional foods has a promising application for metabolic disorders, such as diet-induced obesity (DIO). The objective of this work was to evaluate in mice with DIO, the administration of fermented goat milk (FGM) with Lactobacillus (L.) delbrueckii subsp. bulgaricus CRL1447 and supplemented with different mixes of Lactobacillus strains, on metabolic and immunologic parameters. The strain mixtures (Mix) were formed as follow: Mix 1: L. fermentum CRL1446, L. plantarum CRL1449 and CRL1472 strains, Mix 2: CRL1446 and CRL1449, Mix 3: CRL1446 and CRL1472 and Mix 4: CRL1449 and CRL1472. Seven groups (n = 6) of male C57BL/6 mice were used: Control groups: 1) Standard diet (SD) group: SD + water, 2) FGM group: SD + FGM; 3) Obese (Ob)+FGM group: high fat diet (HFD) + FGM; Obese groups with treatments: 4) Ob+FGM+Mix1 group: HFD + FGM + Mix1, 5) Ob+FGM+Mix2 group: HFD + FGM + Mix2, 6) Ob+FGM+Mix3 group: HFD + FGM + Mix3, 7) Ob+FGM+Mix4 group: HFD + FGM + Mix4. After 10 weeks of feeding, following determinations were made in plasma: glucose and lipid profile by enzymatic methods, leptin by ELISA and cytokines by CBA. Body weight gain (BWG) was evaluated weekly. The results were compared with Ob+FMG group. BWG decreased 34% and 22% in Ob+FGM+Mix2 and Ob+FGM+Mix3 group (respectively). Triglyceride and leptin levels in Ob+FGM+Mix2 group were significantly reduced (35% and 22%, respectively). Regarding total and LDL cholesterol, no significant differences were observed in the different treatment groups. HDL-cholesterol values increased 22% in FGM+Mix 2 and 19% in FGM+Mix3. Levels of glucose values decreased in groups fed with FGM+Mix2 (48%) and FGM+Mix3 (43%). The administration of supplementated FGM with Mix2 reduce levels of pro-inflammatory cytokines (MCP-1 and IL-6), while no significant differences were observed in levels of anti-inflammatory cytokine IL-10. In conclusion, we suggest the use of FGM supplemented with Mix2 as a supplement to nutritional therapies due to its hypotriglyceridemic, hypoglycemic and immunomodulatory properties.Fil: Márquez, María Antonela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Andrada, Lidia Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Medina, Roxana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; ArgentinaFil: Gauffin Cano, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaLVI Annual Meeting Argentine Society for Biochemistry and Molecular Biology; XV Annual Meeting Argentinean Society for General MicrobiologyMendozaArgentinaSociedad Argentina de Investigación en Bioquímica y Biología MolecularSociedad Argentina de Microbiología GeneralTech Science Press2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/193422Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model; LVI Annual Meeting Argentine Society for Biochemistry and Molecular Biology; XV Annual Meeting Argentinean Society for General Microbiology; Mendoza; Argentina; 2020; 116-1160327-95451667-5746CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://file.techscience.com/uploads/attached/file/20210427/20210427073650_26441.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:11Zoai:ri.conicet.gov.ar:11336/193422instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:11.841CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model
title Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model
spellingShingle Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model
Márquez, María Antonela
LACTOBACILLUS
FERMENTED GOAT MILK
OBESITY
title_short Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model
title_full Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model
title_fullStr Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model
title_full_unstemmed Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model
title_sort Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model
dc.creator.none.fl_str_mv Márquez, María Antonela
Russo, Matias Irineo
Andrada, Lidia Estefania
Medina, Roxana Beatriz
Gauffin Cano, María Paola
author Márquez, María Antonela
author_facet Márquez, María Antonela
Russo, Matias Irineo
Andrada, Lidia Estefania
Medina, Roxana Beatriz
Gauffin Cano, María Paola
author_role author
author2 Russo, Matias Irineo
Andrada, Lidia Estefania
Medina, Roxana Beatriz
Gauffin Cano, María Paola
author2_role author
author
author
author
dc.subject.none.fl_str_mv LACTOBACILLUS
FERMENTED GOAT MILK
OBESITY
topic LACTOBACILLUS
FERMENTED GOAT MILK
OBESITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The use of nutritional therapies with functional foods has a promising application for metabolic disorders, such as diet-induced obesity (DIO). The objective of this work was to evaluate in mice with DIO, the administration of fermented goat milk (FGM) with Lactobacillus (L.) delbrueckii subsp. bulgaricus CRL1447 and supplemented with different mixes of Lactobacillus strains, on metabolic and immunologic parameters. The strain mixtures (Mix) were formed as follow: Mix 1: L. fermentum CRL1446, L. plantarum CRL1449 and CRL1472 strains, Mix 2: CRL1446 and CRL1449, Mix 3: CRL1446 and CRL1472 and Mix 4: CRL1449 and CRL1472. Seven groups (n = 6) of male C57BL/6 mice were used: Control groups: 1) Standard diet (SD) group: SD + water, 2) FGM group: SD + FGM; 3) Obese (Ob)+FGM group: high fat diet (HFD) + FGM; Obese groups with treatments: 4) Ob+FGM+Mix1 group: HFD + FGM + Mix1, 5) Ob+FGM+Mix2 group: HFD + FGM + Mix2, 6) Ob+FGM+Mix3 group: HFD + FGM + Mix3, 7) Ob+FGM+Mix4 group: HFD + FGM + Mix4. After 10 weeks of feeding, following determinations were made in plasma: glucose and lipid profile by enzymatic methods, leptin by ELISA and cytokines by CBA. Body weight gain (BWG) was evaluated weekly. The results were compared with Ob+FMG group. BWG decreased 34% and 22% in Ob+FGM+Mix2 and Ob+FGM+Mix3 group (respectively). Triglyceride and leptin levels in Ob+FGM+Mix2 group were significantly reduced (35% and 22%, respectively). Regarding total and LDL cholesterol, no significant differences were observed in the different treatment groups. HDL-cholesterol values increased 22% in FGM+Mix 2 and 19% in FGM+Mix3. Levels of glucose values decreased in groups fed with FGM+Mix2 (48%) and FGM+Mix3 (43%). The administration of supplementated FGM with Mix2 reduce levels of pro-inflammatory cytokines (MCP-1 and IL-6), while no significant differences were observed in levels of anti-inflammatory cytokine IL-10. In conclusion, we suggest the use of FGM supplemented with Mix2 as a supplement to nutritional therapies due to its hypotriglyceridemic, hypoglycemic and immunomodulatory properties.
Fil: Márquez, María Antonela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Russo, Matias Irineo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Andrada, Lidia Estefania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Medina, Roxana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina. Universidad Nacional de Tucumán. Facultad de Agronomía y Zootecnia; Argentina
Fil: Gauffin Cano, María Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
LVI Annual Meeting Argentine Society for Biochemistry and Molecular Biology; XV Annual Meeting Argentinean Society for General Microbiology
Mendoza
Argentina
Sociedad Argentina de Investigación en Bioquímica y Biología Molecular
Sociedad Argentina de Microbiología General
description The use of nutritional therapies with functional foods has a promising application for metabolic disorders, such as diet-induced obesity (DIO). The objective of this work was to evaluate in mice with DIO, the administration of fermented goat milk (FGM) with Lactobacillus (L.) delbrueckii subsp. bulgaricus CRL1447 and supplemented with different mixes of Lactobacillus strains, on metabolic and immunologic parameters. The strain mixtures (Mix) were formed as follow: Mix 1: L. fermentum CRL1446, L. plantarum CRL1449 and CRL1472 strains, Mix 2: CRL1446 and CRL1449, Mix 3: CRL1446 and CRL1472 and Mix 4: CRL1449 and CRL1472. Seven groups (n = 6) of male C57BL/6 mice were used: Control groups: 1) Standard diet (SD) group: SD + water, 2) FGM group: SD + FGM; 3) Obese (Ob)+FGM group: high fat diet (HFD) + FGM; Obese groups with treatments: 4) Ob+FGM+Mix1 group: HFD + FGM + Mix1, 5) Ob+FGM+Mix2 group: HFD + FGM + Mix2, 6) Ob+FGM+Mix3 group: HFD + FGM + Mix3, 7) Ob+FGM+Mix4 group: HFD + FGM + Mix4. After 10 weeks of feeding, following determinations were made in plasma: glucose and lipid profile by enzymatic methods, leptin by ELISA and cytokines by CBA. Body weight gain (BWG) was evaluated weekly. The results were compared with Ob+FMG group. BWG decreased 34% and 22% in Ob+FGM+Mix2 and Ob+FGM+Mix3 group (respectively). Triglyceride and leptin levels in Ob+FGM+Mix2 group were significantly reduced (35% and 22%, respectively). Regarding total and LDL cholesterol, no significant differences were observed in the different treatment groups. HDL-cholesterol values increased 22% in FGM+Mix 2 and 19% in FGM+Mix3. Levels of glucose values decreased in groups fed with FGM+Mix2 (48%) and FGM+Mix3 (43%). The administration of supplementated FGM with Mix2 reduce levels of pro-inflammatory cytokines (MCP-1 and IL-6), while no significant differences were observed in levels of anti-inflammatory cytokine IL-10. In conclusion, we suggest the use of FGM supplemented with Mix2 as a supplement to nutritional therapies due to its hypotriglyceridemic, hypoglycemic and immunomodulatory properties.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/193422
Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model; LVI Annual Meeting Argentine Society for Biochemistry and Molecular Biology; XV Annual Meeting Argentinean Society for General Microbiology; Mendoza; Argentina; 2020; 116-116
0327-9545
1667-5746
CONICET Digital
CONICET
url http://hdl.handle.net/11336/193422
identifier_str_mv Effects of a fermented goat milk with Lactobacillus in a diet-induced obesity murine model; LVI Annual Meeting Argentine Society for Biochemistry and Molecular Biology; XV Annual Meeting Argentinean Society for General Microbiology; Mendoza; Argentina; 2020; 116-116
0327-9545
1667-5746
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://file.techscience.com/uploads/attached/file/20210427/20210427073650_26441.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Tech Science Press
publisher.none.fl_str_mv Tech Science Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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