Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer

Autores
Winum, Jean Yves; Colinas, Pedro Alfonso; Supuran, Claudiu T.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Targeting tumour associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII is now considered as a pertinent approach for the development of new cancer therapeutics against hypoxic tumours. In the last period, with the help of X-ray crystallography, much progress has been achieved for the drug-design of selective CA IX inhibitors, by considering the three main structural elements that govern both potency and selectivity, that is, a zinc binding group (ZBG), an organic scaffold, and one or more side chains substituting the scaffold. The use of sugar moiety in the structure of sulfonamide-based CA inhibitors (CAIs), has allowed the discovery of very potent CA IX inhibitors able to impair the growth of both primary tumors and metastases. The search for specific CA IX inhibitors by using the sugar approach has become an important research field, leading to sulfonamides, sulfamates, sulfamides and coumarins with excellent in vitro activity and relevant potency in vivo, in animal models of cancer. This paper will review the latest development in this hot topic.
Fil: Winum, Jean Yves. Ecole Nationale Supérieure de Chimie de Montpellier; Francia
Fil: Colinas, Pedro Alfonso. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Quimica. Laboratorio de Estudio de Compuestos Organicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Supuran, Claudiu T.. Universita Degli Studi Di Firenze; Italia
Materia
Glyco-Inhibitor
Carbohydrate
Carbonic Anhydrase Ix
Hypoxic Tumors
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13572
Acceder
id CONICETDig_96f37d1f6d9423128c662ebd77e7ab94
oai_identifier_str oai:ri.conicet.gov.ar:11336/13572
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancerWinum, Jean YvesColinas, Pedro AlfonsoSupuran, Claudiu T.Glyco-InhibitorCarbohydrateCarbonic Anhydrase IxHypoxic Tumorshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Targeting tumour associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII is now considered as a pertinent approach for the development of new cancer therapeutics against hypoxic tumours. In the last period, with the help of X-ray crystallography, much progress has been achieved for the drug-design of selective CA IX inhibitors, by considering the three main structural elements that govern both potency and selectivity, that is, a zinc binding group (ZBG), an organic scaffold, and one or more side chains substituting the scaffold. The use of sugar moiety in the structure of sulfonamide-based CA inhibitors (CAIs), has allowed the discovery of very potent CA IX inhibitors able to impair the growth of both primary tumors and metastases. The search for specific CA IX inhibitors by using the sugar approach has become an important research field, leading to sulfonamides, sulfamates, sulfamides and coumarins with excellent in vitro activity and relevant potency in vivo, in animal models of cancer. This paper will review the latest development in this hot topic.Fil: Winum, Jean Yves. Ecole Nationale Supérieure de Chimie de Montpellier; FranciaFil: Colinas, Pedro Alfonso. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Quimica. Laboratorio de Estudio de Compuestos Organicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Supuran, Claudiu T.. Universita Degli Studi Di Firenze; ItaliaElsevier2013-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13572Winum, Jean Yves; Colinas, Pedro Alfonso; Supuran, Claudiu T.; Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer; Elsevier; Bioorganic; 21; 6; 3-2013; 1419-14260968-0896enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmc.2012.10.043info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S096808961200867Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:37:39Zoai:ri.conicet.gov.ar:11336/13572instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:37:40.201CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
title Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
spellingShingle Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
Winum, Jean Yves
Glyco-Inhibitor
Carbohydrate
Carbonic Anhydrase Ix
Hypoxic Tumors
title_short Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
title_full Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
title_fullStr Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
title_full_unstemmed Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
title_sort Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer
dc.creator.none.fl_str_mv Winum, Jean Yves
Colinas, Pedro Alfonso
Supuran, Claudiu T.
author Winum, Jean Yves
author_facet Winum, Jean Yves
Colinas, Pedro Alfonso
Supuran, Claudiu T.
author_role author
author2 Colinas, Pedro Alfonso
Supuran, Claudiu T.
author2_role author
author
dc.subject.none.fl_str_mv Glyco-Inhibitor
Carbohydrate
Carbonic Anhydrase Ix
Hypoxic Tumors
topic Glyco-Inhibitor
Carbohydrate
Carbonic Anhydrase Ix
Hypoxic Tumors
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Targeting tumour associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII is now considered as a pertinent approach for the development of new cancer therapeutics against hypoxic tumours. In the last period, with the help of X-ray crystallography, much progress has been achieved for the drug-design of selective CA IX inhibitors, by considering the three main structural elements that govern both potency and selectivity, that is, a zinc binding group (ZBG), an organic scaffold, and one or more side chains substituting the scaffold. The use of sugar moiety in the structure of sulfonamide-based CA inhibitors (CAIs), has allowed the discovery of very potent CA IX inhibitors able to impair the growth of both primary tumors and metastases. The search for specific CA IX inhibitors by using the sugar approach has become an important research field, leading to sulfonamides, sulfamates, sulfamides and coumarins with excellent in vitro activity and relevant potency in vivo, in animal models of cancer. This paper will review the latest development in this hot topic.
Fil: Winum, Jean Yves. Ecole Nationale Supérieure de Chimie de Montpellier; Francia
Fil: Colinas, Pedro Alfonso. Universidad Nacional de la Plata. Facultad de Ciencias Exactas. Departamento de Quimica. Laboratorio de Estudio de Compuestos Organicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Supuran, Claudiu T.. Universita Degli Studi Di Firenze; Italia
description Targeting tumour associated carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII is now considered as a pertinent approach for the development of new cancer therapeutics against hypoxic tumours. In the last period, with the help of X-ray crystallography, much progress has been achieved for the drug-design of selective CA IX inhibitors, by considering the three main structural elements that govern both potency and selectivity, that is, a zinc binding group (ZBG), an organic scaffold, and one or more side chains substituting the scaffold. The use of sugar moiety in the structure of sulfonamide-based CA inhibitors (CAIs), has allowed the discovery of very potent CA IX inhibitors able to impair the growth of both primary tumors and metastases. The search for specific CA IX inhibitors by using the sugar approach has become an important research field, leading to sulfonamides, sulfamates, sulfamides and coumarins with excellent in vitro activity and relevant potency in vivo, in animal models of cancer. This paper will review the latest development in this hot topic.
publishDate 2013
dc.date.none.fl_str_mv 2013-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13572
Winum, Jean Yves; Colinas, Pedro Alfonso; Supuran, Claudiu T.; Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer; Elsevier; Bioorganic; 21; 6; 3-2013; 1419-1426
0968-0896
url http://hdl.handle.net/11336/13572
identifier_str_mv Winum, Jean Yves; Colinas, Pedro Alfonso; Supuran, Claudiu T.; Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer; Elsevier; Bioorganic; 21; 6; 3-2013; 1419-1426
0968-0896
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmc.2012.10.043
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S096808961200867X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082850768551936
score 13.22299

Publicaciones similares