A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas

Autores
Saeed, Aamer; Florke, Ulrich; Erben, Mauricio Federico
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review provides an overview of the chemistry, structure and potential applications of 1- (acyl/aroyl)-3-(mono-substituted) and 1-(acyl/aroyl)-3,3-(di-substituted) thioureas, with general formula R1C(O)N(1)HC(S)N(3)R2R3. In recent years, the title compounds have found extensive applications as ligands in coordination chemistry. The effect that nitrogen substituents exert on the intra- and intermolecular hydrogen-bonding interactions is discussed, including their role on the coordination properties displayed by these ligands. Novel applications of transition metal complexes bearing 1-(acyl/aroyl)-3-(mono- and di-substituted) thioureas are introduced. Biological aspects are also highlighted. As recently demonstrated, high-throughput screening assay and structure–activity analyses are feasible for this class of compounds. The chemical versatility of 1-(acyl)-3-(substituted) thiourea molecules and the derived metal complexes, together with the possibility of determining detailed structural properties, join biological applications in a promising interdisciplinary approach. The bibliography includes 382 references with emphasis on the literature appearing after 2007.
Fil: Saeed, Aamer. Quaid-I-Azam University; Pakistán
Fil: Florke, Ulrich. Universität Paderborn; Alemania
Fil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Materia
Biological Activity
Metal Complexation
Molecular Structure
Sulfur Chemistry
Thiourea
Vibrational Properties
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24974
Acceder
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network_name_str CONICET Digital (CONICET)
spelling A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureasSaeed, AamerFlorke, UlrichErben, Mauricio FedericoBiological ActivityMetal ComplexationMolecular StructureSulfur ChemistryThioureaVibrational Propertieshttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This review provides an overview of the chemistry, structure and potential applications of 1- (acyl/aroyl)-3-(mono-substituted) and 1-(acyl/aroyl)-3,3-(di-substituted) thioureas, with general formula R1C(O)N(1)HC(S)N(3)R2R3. In recent years, the title compounds have found extensive applications as ligands in coordination chemistry. The effect that nitrogen substituents exert on the intra- and intermolecular hydrogen-bonding interactions is discussed, including their role on the coordination properties displayed by these ligands. Novel applications of transition metal complexes bearing 1-(acyl/aroyl)-3-(mono- and di-substituted) thioureas are introduced. Biological aspects are also highlighted. As recently demonstrated, high-throughput screening assay and structure–activity analyses are feasible for this class of compounds. The chemical versatility of 1-(acyl)-3-(substituted) thiourea molecules and the derived metal complexes, together with the possibility of determining detailed structural properties, join biological applications in a promising interdisciplinary approach. The bibliography includes 382 references with emphasis on the literature appearing after 2007.Fil: Saeed, Aamer. Quaid-I-Azam University; PakistánFil: Florke, Ulrich. Universität Paderborn; AlemaniaFil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaTaylor & Francis Ltd2014-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24974Saeed, Aamer; Florke, Ulrich; Erben, Mauricio Federico; A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas; Taylor & Francis Ltd; Journal Of Sulfur Chemistry; 35; 3; 4-2014; 318-3551741-5993CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/17415993.2013.834904info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/17415993.2013.834904info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:15:21Zoai:ri.conicet.gov.ar:11336/24974instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:15:21.835CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas
title A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas
spellingShingle A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas
Saeed, Aamer
Biological Activity
Metal Complexation
Molecular Structure
Sulfur Chemistry
Thiourea
Vibrational Properties
title_short A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas
title_full A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas
title_fullStr A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas
title_full_unstemmed A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas
title_sort A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas
dc.creator.none.fl_str_mv Saeed, Aamer
Florke, Ulrich
Erben, Mauricio Federico
author Saeed, Aamer
author_facet Saeed, Aamer
Florke, Ulrich
Erben, Mauricio Federico
author_role author
author2 Florke, Ulrich
Erben, Mauricio Federico
author2_role author
author
dc.subject.none.fl_str_mv Biological Activity
Metal Complexation
Molecular Structure
Sulfur Chemistry
Thiourea
Vibrational Properties
topic Biological Activity
Metal Complexation
Molecular Structure
Sulfur Chemistry
Thiourea
Vibrational Properties
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This review provides an overview of the chemistry, structure and potential applications of 1- (acyl/aroyl)-3-(mono-substituted) and 1-(acyl/aroyl)-3,3-(di-substituted) thioureas, with general formula R1C(O)N(1)HC(S)N(3)R2R3. In recent years, the title compounds have found extensive applications as ligands in coordination chemistry. The effect that nitrogen substituents exert on the intra- and intermolecular hydrogen-bonding interactions is discussed, including their role on the coordination properties displayed by these ligands. Novel applications of transition metal complexes bearing 1-(acyl/aroyl)-3-(mono- and di-substituted) thioureas are introduced. Biological aspects are also highlighted. As recently demonstrated, high-throughput screening assay and structure–activity analyses are feasible for this class of compounds. The chemical versatility of 1-(acyl)-3-(substituted) thiourea molecules and the derived metal complexes, together with the possibility of determining detailed structural properties, join biological applications in a promising interdisciplinary approach. The bibliography includes 382 references with emphasis on the literature appearing after 2007.
Fil: Saeed, Aamer. Quaid-I-Azam University; Pakistán
Fil: Florke, Ulrich. Universität Paderborn; Alemania
Fil: Erben, Mauricio Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
description This review provides an overview of the chemistry, structure and potential applications of 1- (acyl/aroyl)-3-(mono-substituted) and 1-(acyl/aroyl)-3,3-(di-substituted) thioureas, with general formula R1C(O)N(1)HC(S)N(3)R2R3. In recent years, the title compounds have found extensive applications as ligands in coordination chemistry. The effect that nitrogen substituents exert on the intra- and intermolecular hydrogen-bonding interactions is discussed, including their role on the coordination properties displayed by these ligands. Novel applications of transition metal complexes bearing 1-(acyl/aroyl)-3-(mono- and di-substituted) thioureas are introduced. Biological aspects are also highlighted. As recently demonstrated, high-throughput screening assay and structure–activity analyses are feasible for this class of compounds. The chemical versatility of 1-(acyl)-3-(substituted) thiourea molecules and the derived metal complexes, together with the possibility of determining detailed structural properties, join biological applications in a promising interdisciplinary approach. The bibliography includes 382 references with emphasis on the literature appearing after 2007.
publishDate 2014
dc.date.none.fl_str_mv 2014-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24974
Saeed, Aamer; Florke, Ulrich; Erben, Mauricio Federico; A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas; Taylor & Francis Ltd; Journal Of Sulfur Chemistry; 35; 3; 4-2014; 318-355
1741-5993
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24974
identifier_str_mv Saeed, Aamer; Florke, Ulrich; Erben, Mauricio Federico; A review on the chemistry, coordination, structure and biological properties of 1-(acyl/aroyl)-3- (substituted) thioureas; Taylor & Francis Ltd; Journal Of Sulfur Chemistry; 35; 3; 4-2014; 318-355
1741-5993
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/17415993.2013.834904
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1080/17415993.2013.834904
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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