The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
- Autores
- Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose Maria
- Año de publicación
- 2004
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range.
Fil: Fernández, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Wenck, Mary Anne. University of North Carolina; Estados Unidos
Fil: Craig, Sydney P.. University of Connecticut; Estados Unidos
Fil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina - Materia
-
BISPHOSPHONATES
CHAGAS
HPRT INHIBITORS
TRYPANOSOMA CRUZI - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/137269
Ver los metadatos del registro completo
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The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compoundsFernández, DanielWenck, Mary AnneCraig, Sydney P.Delfino, Jose MariaBISPHOSPHONATESCHAGASHPRT INHIBITORSTRYPANOSOMA CRUZIhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range.Fil: Fernández, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; ArgentinaFil: Wenck, Mary Anne. University of North Carolina; Estados UnidosFil: Craig, Sydney P.. University of Connecticut; Estados UnidosFil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; ArgentinaPergamon-Elsevier Science Ltd2004-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/137269Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose Maria; The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 17; 9-2004; 4501-45040960-894XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960894X04007978info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2004.06.042info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:42:20Zoai:ri.conicet.gov.ar:11336/137269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:42:20.478CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds |
title |
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds |
spellingShingle |
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds Fernández, Daniel BISPHOSPHONATES CHAGAS HPRT INHIBITORS TRYPANOSOMA CRUZI |
title_short |
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds |
title_full |
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds |
title_fullStr |
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds |
title_full_unstemmed |
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds |
title_sort |
The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds |
dc.creator.none.fl_str_mv |
Fernández, Daniel Wenck, Mary Anne Craig, Sydney P. Delfino, Jose Maria |
author |
Fernández, Daniel |
author_facet |
Fernández, Daniel Wenck, Mary Anne Craig, Sydney P. Delfino, Jose Maria |
author_role |
author |
author2 |
Wenck, Mary Anne Craig, Sydney P. Delfino, Jose Maria |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
BISPHOSPHONATES CHAGAS HPRT INHIBITORS TRYPANOSOMA CRUZI |
topic |
BISPHOSPHONATES CHAGAS HPRT INHIBITORS TRYPANOSOMA CRUZI |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range. Fil: Fernández, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina Fil: Wenck, Mary Anne. University of North Carolina; Estados Unidos Fil: Craig, Sydney P.. University of Connecticut; Estados Unidos Fil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina |
description |
We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/137269 Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose Maria; The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 17; 9-2004; 4501-4504 0960-894X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/137269 |
identifier_str_mv |
Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose Maria; The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 17; 9-2004; 4501-4504 0960-894X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960894X04007978 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2004.06.042 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |