The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds

Autores
Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose Maria
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range.
Fil: Fernández, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Wenck, Mary Anne. University of North Carolina; Estados Unidos
Fil: Craig, Sydney P.. University of Connecticut; Estados Unidos
Fil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Materia
BISPHOSPHONATES
CHAGAS
HPRT INHIBITORS
TRYPANOSOMA CRUZI
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/137269
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compoundsFernández, DanielWenck, Mary AnneCraig, Sydney P.Delfino, Jose MariaBISPHOSPHONATESCHAGASHPRT INHIBITORSTRYPANOSOMA CRUZIhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range.Fil: Fernández, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; ArgentinaFil: Wenck, Mary Anne. University of North Carolina; Estados UnidosFil: Craig, Sydney P.. University of Connecticut; Estados UnidosFil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; ArgentinaPergamon-Elsevier Science Ltd2004-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/137269Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose Maria; The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 17; 9-2004; 4501-45040960-894XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960894X04007978info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2004.06.042info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:10:58Zoai:ri.conicet.gov.ar:11336/137269instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:10:58.541CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
title The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
spellingShingle The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
Fernández, Daniel
BISPHOSPHONATES
CHAGAS
HPRT INHIBITORS
TRYPANOSOMA CRUZI
title_short The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
title_full The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
title_fullStr The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
title_full_unstemmed The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
title_sort The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds
dc.creator.none.fl_str_mv Fernández, Daniel
Wenck, Mary Anne
Craig, Sydney P.
Delfino, Jose Maria
author Fernández, Daniel
author_facet Fernández, Daniel
Wenck, Mary Anne
Craig, Sydney P.
Delfino, Jose Maria
author_role author
author2 Wenck, Mary Anne
Craig, Sydney P.
Delfino, Jose Maria
author2_role author
author
author
dc.subject.none.fl_str_mv BISPHOSPHONATES
CHAGAS
HPRT INHIBITORS
TRYPANOSOMA CRUZI
topic BISPHOSPHONATES
CHAGAS
HPRT INHIBITORS
TRYPANOSOMA CRUZI
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range.
Fil: Fernández, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
Fil: Wenck, Mary Anne. University of North Carolina; Estados Unidos
Fil: Craig, Sydney P.. University of Connecticut; Estados Unidos
Fil: Delfino, Jose Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Biológica; Argentina
description We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range.
publishDate 2004
dc.date.none.fl_str_mv 2004-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/137269
Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose Maria; The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 17; 9-2004; 4501-4504
0960-894X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/137269
identifier_str_mv Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose Maria; The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 17; 9-2004; 4501-4504
0960-894X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960894X04007978
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bmcl.2004.06.042
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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