Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis

Autores
Reisin, R. C.; Rozenfeld, Paula Adriana; Bonardo, P.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females.Cerebrovascular complications are the end result of multiple and complex pathophysiology mechanisms involving endothelial dysfunction and activation, development of chronic inflammatory cascades leading to aprothrombotic state in addition to cardioembolic stroke due to cardiomyopathy and arrhythmias. The recentcoronavirus disease 2019 outbreak share many overlapping deleterious pathogenic mechanisms with those of FDand therefore we analyze the available information regarding the pathophysiology mechanisms of both disordersand hypothesize that there is a markedly increased risk of ischemic and hemorrhagic cerebrovascular complications in Fabry patients suffering from concomitant SARS-CoV-2 infections.
Fil: Reisin, R. C.. Hospital Británico de Buenos Aires; Argentina
Fil: Rozenfeld, Paula Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: Bonardo, P.. Hospital Británico de Buenos Aires; Argentina
Materia
FABRY
STROKE
COVID-19
PATHOPHISIOLOGY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/119374
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/119374
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesisReisin, R. C.Rozenfeld, Paula AdrianaBonardo, P.FABRYSTROKECOVID-19PATHOPHISIOLOGYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females.Cerebrovascular complications are the end result of multiple and complex pathophysiology mechanisms involving endothelial dysfunction and activation, development of chronic inflammatory cascades leading to aprothrombotic state in addition to cardioembolic stroke due to cardiomyopathy and arrhythmias. The recentcoronavirus disease 2019 outbreak share many overlapping deleterious pathogenic mechanisms with those of FDand therefore we analyze the available information regarding the pathophysiology mechanisms of both disordersand hypothesize that there is a markedly increased risk of ischemic and hemorrhagic cerebrovascular complications in Fabry patients suffering from concomitant SARS-CoV-2 infections.Fil: Reisin, R. C.. Hospital Británico de Buenos Aires; ArgentinaFil: Rozenfeld, Paula Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Bonardo, P.. Hospital Británico de Buenos Aires; ArgentinaChurchill Livingstone2020-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/119374Reisin, R. C.; Rozenfeld, Paula Adriana; Bonardo, P.; Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis; Churchill Livingstone; Medical Hypotheses; 144; 11-2020; 1-50306-9877CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306987720327535info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mehy.2020.110282info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494494/pdf/main.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:14:38Zoai:ri.conicet.gov.ar:11336/119374instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:14:39.135CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis
title Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis
spellingShingle Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis
Reisin, R. C.
FABRY
STROKE
COVID-19
PATHOPHISIOLOGY
title_short Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis
title_full Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis
title_fullStr Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis
title_full_unstemmed Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis
title_sort Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis
dc.creator.none.fl_str_mv Reisin, R. C.
Rozenfeld, Paula Adriana
Bonardo, P.
author Reisin, R. C.
author_facet Reisin, R. C.
Rozenfeld, Paula Adriana
Bonardo, P.
author_role author
author2 Rozenfeld, Paula Adriana
Bonardo, P.
author2_role author
author
dc.subject.none.fl_str_mv FABRY
STROKE
COVID-19
PATHOPHISIOLOGY
topic FABRY
STROKE
COVID-19
PATHOPHISIOLOGY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females.Cerebrovascular complications are the end result of multiple and complex pathophysiology mechanisms involving endothelial dysfunction and activation, development of chronic inflammatory cascades leading to aprothrombotic state in addition to cardioembolic stroke due to cardiomyopathy and arrhythmias. The recentcoronavirus disease 2019 outbreak share many overlapping deleterious pathogenic mechanisms with those of FDand therefore we analyze the available information regarding the pathophysiology mechanisms of both disordersand hypothesize that there is a markedly increased risk of ischemic and hemorrhagic cerebrovascular complications in Fabry patients suffering from concomitant SARS-CoV-2 infections.
Fil: Reisin, R. C.. Hospital Británico de Buenos Aires; Argentina
Fil: Rozenfeld, Paula Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: Bonardo, P.. Hospital Británico de Buenos Aires; Argentina
description Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females.Cerebrovascular complications are the end result of multiple and complex pathophysiology mechanisms involving endothelial dysfunction and activation, development of chronic inflammatory cascades leading to aprothrombotic state in addition to cardioembolic stroke due to cardiomyopathy and arrhythmias. The recentcoronavirus disease 2019 outbreak share many overlapping deleterious pathogenic mechanisms with those of FDand therefore we analyze the available information regarding the pathophysiology mechanisms of both disordersand hypothesize that there is a markedly increased risk of ischemic and hemorrhagic cerebrovascular complications in Fabry patients suffering from concomitant SARS-CoV-2 infections.
publishDate 2020
dc.date.none.fl_str_mv 2020-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/119374
Reisin, R. C.; Rozenfeld, Paula Adriana; Bonardo, P.; Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis; Churchill Livingstone; Medical Hypotheses; 144; 11-2020; 1-5
0306-9877
CONICET Digital
CONICET
url http://hdl.handle.net/11336/119374
identifier_str_mv Reisin, R. C.; Rozenfeld, Paula Adriana; Bonardo, P.; Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis; Churchill Livingstone; Medical Hypotheses; 144; 11-2020; 1-5
0306-9877
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306987720327535
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mehy.2020.110282
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494494/pdf/main.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Churchill Livingstone
publisher.none.fl_str_mv Churchill Livingstone
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781569547632640
score 12.982451

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