Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis
- Autores
- Reisin, R. C.; Rozenfeld, Paula Adriana; Bonardo, P.
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females.Cerebrovascular complications are the end result of multiple and complex pathophysiology mechanisms involving endothelial dysfunction and activation, development of chronic inflammatory cascades leading to aprothrombotic state in addition to cardioembolic stroke due to cardiomyopathy and arrhythmias. The recentcoronavirus disease 2019 outbreak share many overlapping deleterious pathogenic mechanisms with those of FDand therefore we analyze the available information regarding the pathophysiology mechanisms of both disordersand hypothesize that there is a markedly increased risk of ischemic and hemorrhagic cerebrovascular complications in Fabry patients suffering from concomitant SARS-CoV-2 infections.
Fil: Reisin, R. C.. Hospital Británico de Buenos Aires; Argentina
Fil: Rozenfeld, Paula Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: Bonardo, P.. Hospital Británico de Buenos Aires; Argentina - Materia
-
FABRY
STROKE
COVID-19
PATHOPHISIOLOGY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/119374
Ver los metadatos del registro completo
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Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesisReisin, R. C.Rozenfeld, Paula AdrianaBonardo, P.FABRYSTROKECOVID-19PATHOPHISIOLOGYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females.Cerebrovascular complications are the end result of multiple and complex pathophysiology mechanisms involving endothelial dysfunction and activation, development of chronic inflammatory cascades leading to aprothrombotic state in addition to cardioembolic stroke due to cardiomyopathy and arrhythmias. The recentcoronavirus disease 2019 outbreak share many overlapping deleterious pathogenic mechanisms with those of FDand therefore we analyze the available information regarding the pathophysiology mechanisms of both disordersand hypothesize that there is a markedly increased risk of ischemic and hemorrhagic cerebrovascular complications in Fabry patients suffering from concomitant SARS-CoV-2 infections.Fil: Reisin, R. C.. Hospital Británico de Buenos Aires; ArgentinaFil: Rozenfeld, Paula Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: Bonardo, P.. Hospital Británico de Buenos Aires; ArgentinaChurchill Livingstone2020-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/119374Reisin, R. C.; Rozenfeld, Paula Adriana; Bonardo, P.; Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis; Churchill Livingstone; Medical Hypotheses; 144; 11-2020; 1-50306-9877CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306987720327535info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mehy.2020.110282info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494494/pdf/main.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:52Zoai:ri.conicet.gov.ar:11336/119374instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:52.337CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis |
title |
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis |
spellingShingle |
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis Reisin, R. C. FABRY STROKE COVID-19 PATHOPHISIOLOGY |
title_short |
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis |
title_full |
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis |
title_fullStr |
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis |
title_full_unstemmed |
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis |
title_sort |
Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis |
dc.creator.none.fl_str_mv |
Reisin, R. C. Rozenfeld, Paula Adriana Bonardo, P. |
author |
Reisin, R. C. |
author_facet |
Reisin, R. C. Rozenfeld, Paula Adriana Bonardo, P. |
author_role |
author |
author2 |
Rozenfeld, Paula Adriana Bonardo, P. |
author2_role |
author author |
dc.subject.none.fl_str_mv |
FABRY STROKE COVID-19 PATHOPHISIOLOGY |
topic |
FABRY STROKE COVID-19 PATHOPHISIOLOGY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females.Cerebrovascular complications are the end result of multiple and complex pathophysiology mechanisms involving endothelial dysfunction and activation, development of chronic inflammatory cascades leading to aprothrombotic state in addition to cardioembolic stroke due to cardiomyopathy and arrhythmias. The recentcoronavirus disease 2019 outbreak share many overlapping deleterious pathogenic mechanisms with those of FDand therefore we analyze the available information regarding the pathophysiology mechanisms of both disordersand hypothesize that there is a markedly increased risk of ischemic and hemorrhagic cerebrovascular complications in Fabry patients suffering from concomitant SARS-CoV-2 infections. Fil: Reisin, R. C.. Hospital Británico de Buenos Aires; Argentina Fil: Rozenfeld, Paula Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina Fil: Bonardo, P.. Hospital Británico de Buenos Aires; Argentina |
description |
Stroke is a severe and frequent complication of Fabry disease (FD), affecting both males and females.Cerebrovascular complications are the end result of multiple and complex pathophysiology mechanisms involving endothelial dysfunction and activation, development of chronic inflammatory cascades leading to aprothrombotic state in addition to cardioembolic stroke due to cardiomyopathy and arrhythmias. The recentcoronavirus disease 2019 outbreak share many overlapping deleterious pathogenic mechanisms with those of FDand therefore we analyze the available information regarding the pathophysiology mechanisms of both disordersand hypothesize that there is a markedly increased risk of ischemic and hemorrhagic cerebrovascular complications in Fabry patients suffering from concomitant SARS-CoV-2 infections. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/119374 Reisin, R. C.; Rozenfeld, Paula Adriana; Bonardo, P.; Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis; Churchill Livingstone; Medical Hypotheses; 144; 11-2020; 1-5 0306-9877 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/119374 |
identifier_str_mv |
Reisin, R. C.; Rozenfeld, Paula Adriana; Bonardo, P.; Fabry disease patients have an increased risk of stroke in the COVID-19 ERA: A hypothesis; Churchill Livingstone; Medical Hypotheses; 144; 11-2020; 1-5 0306-9877 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0306987720327535 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.mehy.2020.110282 info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494494/pdf/main.pdf |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Churchill Livingstone |
publisher.none.fl_str_mv |
Churchill Livingstone |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |