A new role for histone demethylases in the maintenance of plant genome integrity
- Autores
- Antunez Sanchez, Javier; Naish, Matthew; Ramirez Prado, Juan Sebastian; Ohno, Sho; Huang, Ying; Dawson, Alexander; Opassathian, Korawit; Manza Mianza, Deborah; Ariel, Federico Damian; Raynaud, Cecile; Wibowo, Anjar; Daron, Josquin; Ueda, Minako; Latrasse, David; Slotkin, R Keith; Weigel, Detlef; Benhamed, Moussa; Gutierrez Marcos, Jose
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction.
Fil: Antunez Sanchez, Javier. University of Warwick; Reino Unido
Fil: Naish, Matthew. University of Warwick; Reino Unido
Fil: Ramirez Prado, Juan Sebastian. Centre National de la Recherche Scientifique; Francia
Fil: Ohno, Sho. University of Warwick; Reino Unido
Fil: Huang, Ying. Centre National de la Recherche Scientifique; Francia
Fil: Dawson, Alexander. University of Warwick; Reino Unido
Fil: Opassathian, Korawit. University of Warwick; Reino Unido
Fil: Manza Mianza, Deborah. Centre National de la Recherche Scientifique; Francia
Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Raynaud, Cecile. Centre National de la Recherche Scientifique; Francia
Fil: Wibowo, Anjar. Max Planck Institute For Developmental Biology; Alemania
Fil: Daron, Josquin. Ohio University; Estados Unidos
Fil: Ueda, Minako. Nagoya University; Japón
Fil: Latrasse, David. Centre National de la Recherche Scientifique; Francia
Fil: Slotkin, R Keith. University of Missouri; Estados Unidos
Fil: Weigel, Detlef. Max Planck Institute For Developmental Biology; Alemania
Fil: Benhamed, Moussa. Centre National de la Recherche Scientifique; Francia
Fil: Gutierrez Marcos, Jose. University of Warwick; Reino Unido - Materia
-
ARABIDOPSIS
CHROMATIN
DNA METHYLATION
EPIMUTATION
TRANSPOSON - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/145327
Ver los metadatos del registro completo
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A new role for histone demethylases in the maintenance of plant genome integrityAntunez Sanchez, JavierNaish, MatthewRamirez Prado, Juan SebastianOhno, ShoHuang, YingDawson, AlexanderOpassathian, KorawitManza Mianza, DeborahAriel, Federico DamianRaynaud, CecileWibowo, AnjarDaron, JosquinUeda, MinakoLatrasse, DavidSlotkin, R KeithWeigel, DetlefBenhamed, MoussaGutierrez Marcos, JoseARABIDOPSISCHROMATINDNA METHYLATIONEPIMUTATIONTRANSPOSONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction.Fil: Antunez Sanchez, Javier. University of Warwick; Reino UnidoFil: Naish, Matthew. University of Warwick; Reino UnidoFil: Ramirez Prado, Juan Sebastian. Centre National de la Recherche Scientifique; FranciaFil: Ohno, Sho. University of Warwick; Reino UnidoFil: Huang, Ying. Centre National de la Recherche Scientifique; FranciaFil: Dawson, Alexander. University of Warwick; Reino UnidoFil: Opassathian, Korawit. University of Warwick; Reino UnidoFil: Manza Mianza, Deborah. Centre National de la Recherche Scientifique; FranciaFil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Raynaud, Cecile. Centre National de la Recherche Scientifique; FranciaFil: Wibowo, Anjar. Max Planck Institute For Developmental Biology; AlemaniaFil: Daron, Josquin. Ohio University; Estados UnidosFil: Ueda, Minako. Nagoya University; JapónFil: Latrasse, David. Centre National de la Recherche Scientifique; FranciaFil: Slotkin, R Keith. University of Missouri; Estados UnidosFil: Weigel, Detlef. Max Planck Institute For Developmental Biology; AlemaniaFil: Benhamed, Moussa. Centre National de la Recherche Scientifique; FranciaFil: Gutierrez Marcos, Jose. University of Warwick; Reino UnidoeLife Sciences Publications2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145327Antunez Sanchez, Javier; Naish, Matthew; Ramirez Prado, Juan Sebastian; Ohno, Sho; Huang, Ying; et al.; A new role for histone demethylases in the maintenance of plant genome integrity; eLife Sciences Publications; eLife; 9; 10-2020; 1-322050-084XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/58533info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.58533info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:27Zoai:ri.conicet.gov.ar:11336/145327instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:28.067CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
A new role for histone demethylases in the maintenance of plant genome integrity |
| title |
A new role for histone demethylases in the maintenance of plant genome integrity |
| spellingShingle |
A new role for histone demethylases in the maintenance of plant genome integrity Antunez Sanchez, Javier ARABIDOPSIS CHROMATIN DNA METHYLATION EPIMUTATION TRANSPOSON |
| title_short |
A new role for histone demethylases in the maintenance of plant genome integrity |
| title_full |
A new role for histone demethylases in the maintenance of plant genome integrity |
| title_fullStr |
A new role for histone demethylases in the maintenance of plant genome integrity |
| title_full_unstemmed |
A new role for histone demethylases in the maintenance of plant genome integrity |
| title_sort |
A new role for histone demethylases in the maintenance of plant genome integrity |
| dc.creator.none.fl_str_mv |
Antunez Sanchez, Javier Naish, Matthew Ramirez Prado, Juan Sebastian Ohno, Sho Huang, Ying Dawson, Alexander Opassathian, Korawit Manza Mianza, Deborah Ariel, Federico Damian Raynaud, Cecile Wibowo, Anjar Daron, Josquin Ueda, Minako Latrasse, David Slotkin, R Keith Weigel, Detlef Benhamed, Moussa Gutierrez Marcos, Jose |
| author |
Antunez Sanchez, Javier |
| author_facet |
Antunez Sanchez, Javier Naish, Matthew Ramirez Prado, Juan Sebastian Ohno, Sho Huang, Ying Dawson, Alexander Opassathian, Korawit Manza Mianza, Deborah Ariel, Federico Damian Raynaud, Cecile Wibowo, Anjar Daron, Josquin Ueda, Minako Latrasse, David Slotkin, R Keith Weigel, Detlef Benhamed, Moussa Gutierrez Marcos, Jose |
| author_role |
author |
| author2 |
Naish, Matthew Ramirez Prado, Juan Sebastian Ohno, Sho Huang, Ying Dawson, Alexander Opassathian, Korawit Manza Mianza, Deborah Ariel, Federico Damian Raynaud, Cecile Wibowo, Anjar Daron, Josquin Ueda, Minako Latrasse, David Slotkin, R Keith Weigel, Detlef Benhamed, Moussa Gutierrez Marcos, Jose |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
ARABIDOPSIS CHROMATIN DNA METHYLATION EPIMUTATION TRANSPOSON |
| topic |
ARABIDOPSIS CHROMATIN DNA METHYLATION EPIMUTATION TRANSPOSON |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction. Fil: Antunez Sanchez, Javier. University of Warwick; Reino Unido Fil: Naish, Matthew. University of Warwick; Reino Unido Fil: Ramirez Prado, Juan Sebastian. Centre National de la Recherche Scientifique; Francia Fil: Ohno, Sho. University of Warwick; Reino Unido Fil: Huang, Ying. Centre National de la Recherche Scientifique; Francia Fil: Dawson, Alexander. University of Warwick; Reino Unido Fil: Opassathian, Korawit. University of Warwick; Reino Unido Fil: Manza Mianza, Deborah. Centre National de la Recherche Scientifique; Francia Fil: Ariel, Federico Damian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina Fil: Raynaud, Cecile. Centre National de la Recherche Scientifique; Francia Fil: Wibowo, Anjar. Max Planck Institute For Developmental Biology; Alemania Fil: Daron, Josquin. Ohio University; Estados Unidos Fil: Ueda, Minako. Nagoya University; Japón Fil: Latrasse, David. Centre National de la Recherche Scientifique; Francia Fil: Slotkin, R Keith. University of Missouri; Estados Unidos Fil: Weigel, Detlef. Max Planck Institute For Developmental Biology; Alemania Fil: Benhamed, Moussa. Centre National de la Recherche Scientifique; Francia Fil: Gutierrez Marcos, Jose. University of Warwick; Reino Unido |
| description |
Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction. |
| publishDate |
2020 |
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2020-10 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/145327 Antunez Sanchez, Javier; Naish, Matthew; Ramirez Prado, Juan Sebastian; Ohno, Sho; Huang, Ying; et al.; A new role for histone demethylases in the maintenance of plant genome integrity; eLife Sciences Publications; eLife; 9; 10-2020; 1-32 2050-084X CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/145327 |
| identifier_str_mv |
Antunez Sanchez, Javier; Naish, Matthew; Ramirez Prado, Juan Sebastian; Ohno, Sho; Huang, Ying; et al.; A new role for histone demethylases in the maintenance of plant genome integrity; eLife Sciences Publications; eLife; 9; 10-2020; 1-32 2050-084X CONICET Digital CONICET |
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eng |
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eng |
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eLife Sciences Publications |
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