A STRP-ed definition of Structured Tandem Repeats in Proteins

Autores
Monzon, Alexander Miguel; Arrías, Paula Nazarena; Elofsson, Arne; Mier, Pablo; Andrade Navarro, Miguel A.; Bevilacqua, Martina; Clementel, Damiano; Bateman, Alex; Hirsh, Layla; Fornasari, Maria Silvina; Parisi, Gustavo Daniel; Piovesan, Damiano; Kajava, Andrey V.; Tosatto, Silvio C. E.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Tandem Repeat Proteins (TRPs) are a class of proteins with repetitive amino acid sequences that have been studied extensively for over two decades. Different features at the level of sequence, structure, function and evolution have been attributed to them by various authors. And yet many of its salient features appear only when looking at specific subclasses of protein tandem repeats. Here, we attempt to rationalize the existing knowledge on Tandem Repeat Proteins (TRPs) by pointing out several dichotomies. The emerging picture is more nuanced than generally assumed and allows us to draw some boundaries of what is not a "proper" TRP. We conclude with an operational definition of a specific subset, which we have denominated STRPs (Structural Tandem Repeat Proteins), which separates a subclass of tandem repeats with distinctive features from several other less well-defined types of repeats. We believe that this definition will help researchers in the field to better characterize the biological meaning of this large yet largely understudied group of proteins.
Fil: Monzon, Alexander Miguel. Università di Padova; Italia
Fil: Arrías, Paula Nazarena. Università di Padova; Italia
Fil: Elofsson, Arne. Stockholms Universitet; Suecia
Fil: Mier, Pablo. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Andrade Navarro, Miguel A.. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Bevilacqua, Martina. Università di Padova; Italia
Fil: Clementel, Damiano. Università di Padova; Italia
Fil: Bateman, Alex. No especifíca;
Fil: Hirsh, Layla. Pontificia Universidad Católica de Perú; Perú
Fil: Fornasari, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Piovesan, Damiano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Kajava, Andrey V.. Université Montpellier II; Francia
Fil: Tosatto, Silvio C. E.. Università di Padova; Italia
Materia
Repeats
proteins
database
definition
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/237967
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/237967
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A STRP-ed definition of Structured Tandem Repeats in ProteinsMonzon, Alexander MiguelArrías, Paula NazarenaElofsson, ArneMier, PabloAndrade Navarro, Miguel A.Bevilacqua, MartinaClementel, DamianoBateman, AlexHirsh, LaylaFornasari, Maria SilvinaParisi, Gustavo DanielPiovesan, DamianoKajava, Andrey V.Tosatto, Silvio C. E.Repeatsproteinsdatabasedefinitionhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Tandem Repeat Proteins (TRPs) are a class of proteins with repetitive amino acid sequences that have been studied extensively for over two decades. Different features at the level of sequence, structure, function and evolution have been attributed to them by various authors. And yet many of its salient features appear only when looking at specific subclasses of protein tandem repeats. Here, we attempt to rationalize the existing knowledge on Tandem Repeat Proteins (TRPs) by pointing out several dichotomies. The emerging picture is more nuanced than generally assumed and allows us to draw some boundaries of what is not a "proper" TRP. We conclude with an operational definition of a specific subset, which we have denominated STRPs (Structural Tandem Repeat Proteins), which separates a subclass of tandem repeats with distinctive features from several other less well-defined types of repeats. We believe that this definition will help researchers in the field to better characterize the biological meaning of this large yet largely understudied group of proteins.Fil: Monzon, Alexander Miguel. Università di Padova; ItaliaFil: Arrías, Paula Nazarena. Università di Padova; ItaliaFil: Elofsson, Arne. Stockholms Universitet; SueciaFil: Mier, Pablo. Johannes Gutenberg Universitat Mainz; AlemaniaFil: Andrade Navarro, Miguel A.. Johannes Gutenberg Universitat Mainz; AlemaniaFil: Bevilacqua, Martina. Università di Padova; ItaliaFil: Clementel, Damiano. Università di Padova; ItaliaFil: Bateman, Alex. No especifíca;Fil: Hirsh, Layla. Pontificia Universidad Católica de Perú; PerúFil: Fornasari, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Piovesan, Damiano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Kajava, Andrey V.. Université Montpellier II; FranciaFil: Tosatto, Silvio C. E.. Università di Padova; ItaliaAcademic Press Inc Elsevier Science2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/237967Monzon, Alexander Miguel; Arrías, Paula Nazarena; Elofsson, Arne; Mier, Pablo; Andrade Navarro, Miguel A.; et al.; A STRP-ed definition of Structured Tandem Repeats in Proteins; Academic Press Inc Elsevier Science; Journal Of Structural Biology; 215; 4; 12-20231047-8477CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsb.2023.108023info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:03Zoai:ri.conicet.gov.ar:11336/237967instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:03.51CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A STRP-ed definition of Structured Tandem Repeats in Proteins
title A STRP-ed definition of Structured Tandem Repeats in Proteins
spellingShingle A STRP-ed definition of Structured Tandem Repeats in Proteins
Monzon, Alexander Miguel
Repeats
proteins
database
definition
title_short A STRP-ed definition of Structured Tandem Repeats in Proteins
title_full A STRP-ed definition of Structured Tandem Repeats in Proteins
title_fullStr A STRP-ed definition of Structured Tandem Repeats in Proteins
title_full_unstemmed A STRP-ed definition of Structured Tandem Repeats in Proteins
title_sort A STRP-ed definition of Structured Tandem Repeats in Proteins
dc.creator.none.fl_str_mv Monzon, Alexander Miguel
Arrías, Paula Nazarena
Elofsson, Arne
Mier, Pablo
Andrade Navarro, Miguel A.
Bevilacqua, Martina
Clementel, Damiano
Bateman, Alex
Hirsh, Layla
Fornasari, Maria Silvina
Parisi, Gustavo Daniel
Piovesan, Damiano
Kajava, Andrey V.
Tosatto, Silvio C. E.
author Monzon, Alexander Miguel
author_facet Monzon, Alexander Miguel
Arrías, Paula Nazarena
Elofsson, Arne
Mier, Pablo
Andrade Navarro, Miguel A.
Bevilacqua, Martina
Clementel, Damiano
Bateman, Alex
Hirsh, Layla
Fornasari, Maria Silvina
Parisi, Gustavo Daniel
Piovesan, Damiano
Kajava, Andrey V.
Tosatto, Silvio C. E.
author_role author
author2 Arrías, Paula Nazarena
Elofsson, Arne
Mier, Pablo
Andrade Navarro, Miguel A.
Bevilacqua, Martina
Clementel, Damiano
Bateman, Alex
Hirsh, Layla
Fornasari, Maria Silvina
Parisi, Gustavo Daniel
Piovesan, Damiano
Kajava, Andrey V.
Tosatto, Silvio C. E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Repeats
proteins
database
definition
topic Repeats
proteins
database
definition
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Tandem Repeat Proteins (TRPs) are a class of proteins with repetitive amino acid sequences that have been studied extensively for over two decades. Different features at the level of sequence, structure, function and evolution have been attributed to them by various authors. And yet many of its salient features appear only when looking at specific subclasses of protein tandem repeats. Here, we attempt to rationalize the existing knowledge on Tandem Repeat Proteins (TRPs) by pointing out several dichotomies. The emerging picture is more nuanced than generally assumed and allows us to draw some boundaries of what is not a "proper" TRP. We conclude with an operational definition of a specific subset, which we have denominated STRPs (Structural Tandem Repeat Proteins), which separates a subclass of tandem repeats with distinctive features from several other less well-defined types of repeats. We believe that this definition will help researchers in the field to better characterize the biological meaning of this large yet largely understudied group of proteins.
Fil: Monzon, Alexander Miguel. Università di Padova; Italia
Fil: Arrías, Paula Nazarena. Università di Padova; Italia
Fil: Elofsson, Arne. Stockholms Universitet; Suecia
Fil: Mier, Pablo. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Andrade Navarro, Miguel A.. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Bevilacqua, Martina. Università di Padova; Italia
Fil: Clementel, Damiano. Università di Padova; Italia
Fil: Bateman, Alex. No especifíca;
Fil: Hirsh, Layla. Pontificia Universidad Católica de Perú; Perú
Fil: Fornasari, Maria Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Parisi, Gustavo Daniel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Piovesan, Damiano. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Kajava, Andrey V.. Université Montpellier II; Francia
Fil: Tosatto, Silvio C. E.. Università di Padova; Italia
description Tandem Repeat Proteins (TRPs) are a class of proteins with repetitive amino acid sequences that have been studied extensively for over two decades. Different features at the level of sequence, structure, function and evolution have been attributed to them by various authors. And yet many of its salient features appear only when looking at specific subclasses of protein tandem repeats. Here, we attempt to rationalize the existing knowledge on Tandem Repeat Proteins (TRPs) by pointing out several dichotomies. The emerging picture is more nuanced than generally assumed and allows us to draw some boundaries of what is not a "proper" TRP. We conclude with an operational definition of a specific subset, which we have denominated STRPs (Structural Tandem Repeat Proteins), which separates a subclass of tandem repeats with distinctive features from several other less well-defined types of repeats. We believe that this definition will help researchers in the field to better characterize the biological meaning of this large yet largely understudied group of proteins.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/237967
Monzon, Alexander Miguel; Arrías, Paula Nazarena; Elofsson, Arne; Mier, Pablo; Andrade Navarro, Miguel A.; et al.; A STRP-ed definition of Structured Tandem Repeats in Proteins; Academic Press Inc Elsevier Science; Journal Of Structural Biology; 215; 4; 12-2023
1047-8477
CONICET Digital
CONICET
url http://hdl.handle.net/11336/237967
identifier_str_mv Monzon, Alexander Miguel; Arrías, Paula Nazarena; Elofsson, Arne; Mier, Pablo; Andrade Navarro, Miguel A.; et al.; A STRP-ed definition of Structured Tandem Repeats in Proteins; Academic Press Inc Elsevier Science; Journal Of Structural Biology; 215; 4; 12-2023
1047-8477
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jsb.2023.108023
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269673659301888
score 13.13397

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