Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer

Autores
Nunes, Adenia Mirela Alves; de Oliveira Alves Júnior, José; Springer, Valeria Haydee; Júnior, João Augusto Oshiro
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The incidence of breast cancer has been increasing over the last four decades, although the mortality rate has decreased. Endocrine therapy and chemotherapy are the most used options for cancer treatment but several obstacles are still attributed to these therapies. Smart materials, such as nanocarriers for targeting, delivery and release of active ingredients, sensitive to intrinsic-stimuli (pH-responsive, redox-responsive, enzyme- responsive, and thermo-responsive) and extrinsic-stimuli (ultrasound-responsive, magnetic-responsive, light-responsive) have been studied as a novel strategy in breast cancer therapy. Cyclodextrins (CDs) are used in the design of these stimuli-responsive drug carrier and delivery systems, either through inclusion complexes with hydrophobic molecules or covalent bonds with large structures to generate new materials. The present work aims to gather and integrate recent data from in vitro and in vivo preclinical studies of CD-based stimuli- responsive systems to contribute to the research in treating breast cancer. All drug carriers showed high in vitro release rates in the presence of a stimulus. The stimuli-responsive nanoplatforms presented biocompatibility and satisfactory results of IC50, inhibition of cell viability and antitumor activity against several breast cancer cell lines. Additionally, these systems led to a significant reduction in drug dosages, which encouraged possible clinical studies for better alternatives to traditional antitumor therapies.
Fil: Nunes, Adenia Mirela Alves. Universidade Estadual da Paraiba; Brasil
Fil: de Oliveira Alves Júnior, José. Universidade Estadual da Paraiba; Brasil
Fil: Springer, Valeria Haydee. Universidad Nacional del Sur. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Júnior, João Augusto Oshiro. Universidade Estadual da Paraiba; Brasil
Materia
RESPONSIVE SYSTEMS
CANCER CELLS
EXTRINSIC STIMULUS
INTRINSIC STIMULUS
NANOCARRIERS
POLYMERIC SYSTEMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/257687
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Intelligent Systems based on Cyclodextrins for the Treatment of Breast CancerNunes, Adenia Mirela Alvesde Oliveira Alves Júnior, JoséSpringer, Valeria HaydeeJúnior, João Augusto OshiroRESPONSIVE SYSTEMSCANCER CELLSEXTRINSIC STIMULUSINTRINSIC STIMULUSNANOCARRIERSPOLYMERIC SYSTEMShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The incidence of breast cancer has been increasing over the last four decades, although the mortality rate has decreased. Endocrine therapy and chemotherapy are the most used options for cancer treatment but several obstacles are still attributed to these therapies. Smart materials, such as nanocarriers for targeting, delivery and release of active ingredients, sensitive to intrinsic-stimuli (pH-responsive, redox-responsive, enzyme- responsive, and thermo-responsive) and extrinsic-stimuli (ultrasound-responsive, magnetic-responsive, light-responsive) have been studied as a novel strategy in breast cancer therapy. Cyclodextrins (CDs) are used in the design of these stimuli-responsive drug carrier and delivery systems, either through inclusion complexes with hydrophobic molecules or covalent bonds with large structures to generate new materials. The present work aims to gather and integrate recent data from in vitro and in vivo preclinical studies of CD-based stimuli- responsive systems to contribute to the research in treating breast cancer. All drug carriers showed high in vitro release rates in the presence of a stimulus. The stimuli-responsive nanoplatforms presented biocompatibility and satisfactory results of IC50, inhibition of cell viability and antitumor activity against several breast cancer cell lines. Additionally, these systems led to a significant reduction in drug dosages, which encouraged possible clinical studies for better alternatives to traditional antitumor therapies.Fil: Nunes, Adenia Mirela Alves. Universidade Estadual da Paraiba; BrasilFil: de Oliveira Alves Júnior, José. Universidade Estadual da Paraiba; BrasilFil: Springer, Valeria Haydee. Universidad Nacional del Sur. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Júnior, João Augusto Oshiro. Universidade Estadual da Paraiba; BrasilBentham Science Publishers2024-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/257687Nunes, Adenia Mirela Alves; de Oliveira Alves Júnior, José; Springer, Valeria Haydee; Júnior, João Augusto Oshiro; Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer; Bentham Science Publishers; Current Pharmaceutical Design; 30; 30; 8-2024; 2345-23631381-6128CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/231614/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/0113816128291108240613094515info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:56:42Zoai:ri.conicet.gov.ar:11336/257687instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:56:42.592CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
title Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
spellingShingle Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
Nunes, Adenia Mirela Alves
RESPONSIVE SYSTEMS
CANCER CELLS
EXTRINSIC STIMULUS
INTRINSIC STIMULUS
NANOCARRIERS
POLYMERIC SYSTEMS
title_short Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
title_full Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
title_fullStr Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
title_full_unstemmed Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
title_sort Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
dc.creator.none.fl_str_mv Nunes, Adenia Mirela Alves
de Oliveira Alves Júnior, José
Springer, Valeria Haydee
Júnior, João Augusto Oshiro
author Nunes, Adenia Mirela Alves
author_facet Nunes, Adenia Mirela Alves
de Oliveira Alves Júnior, José
Springer, Valeria Haydee
Júnior, João Augusto Oshiro
author_role author
author2 de Oliveira Alves Júnior, José
Springer, Valeria Haydee
Júnior, João Augusto Oshiro
author2_role author
author
author
dc.subject.none.fl_str_mv RESPONSIVE SYSTEMS
CANCER CELLS
EXTRINSIC STIMULUS
INTRINSIC STIMULUS
NANOCARRIERS
POLYMERIC SYSTEMS
topic RESPONSIVE SYSTEMS
CANCER CELLS
EXTRINSIC STIMULUS
INTRINSIC STIMULUS
NANOCARRIERS
POLYMERIC SYSTEMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The incidence of breast cancer has been increasing over the last four decades, although the mortality rate has decreased. Endocrine therapy and chemotherapy are the most used options for cancer treatment but several obstacles are still attributed to these therapies. Smart materials, such as nanocarriers for targeting, delivery and release of active ingredients, sensitive to intrinsic-stimuli (pH-responsive, redox-responsive, enzyme- responsive, and thermo-responsive) and extrinsic-stimuli (ultrasound-responsive, magnetic-responsive, light-responsive) have been studied as a novel strategy in breast cancer therapy. Cyclodextrins (CDs) are used in the design of these stimuli-responsive drug carrier and delivery systems, either through inclusion complexes with hydrophobic molecules or covalent bonds with large structures to generate new materials. The present work aims to gather and integrate recent data from in vitro and in vivo preclinical studies of CD-based stimuli- responsive systems to contribute to the research in treating breast cancer. All drug carriers showed high in vitro release rates in the presence of a stimulus. The stimuli-responsive nanoplatforms presented biocompatibility and satisfactory results of IC50, inhibition of cell viability and antitumor activity against several breast cancer cell lines. Additionally, these systems led to a significant reduction in drug dosages, which encouraged possible clinical studies for better alternatives to traditional antitumor therapies.
Fil: Nunes, Adenia Mirela Alves. Universidade Estadual da Paraiba; Brasil
Fil: de Oliveira Alves Júnior, José. Universidade Estadual da Paraiba; Brasil
Fil: Springer, Valeria Haydee. Universidad Nacional del Sur. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Júnior, João Augusto Oshiro. Universidade Estadual da Paraiba; Brasil
description The incidence of breast cancer has been increasing over the last four decades, although the mortality rate has decreased. Endocrine therapy and chemotherapy are the most used options for cancer treatment but several obstacles are still attributed to these therapies. Smart materials, such as nanocarriers for targeting, delivery and release of active ingredients, sensitive to intrinsic-stimuli (pH-responsive, redox-responsive, enzyme- responsive, and thermo-responsive) and extrinsic-stimuli (ultrasound-responsive, magnetic-responsive, light-responsive) have been studied as a novel strategy in breast cancer therapy. Cyclodextrins (CDs) are used in the design of these stimuli-responsive drug carrier and delivery systems, either through inclusion complexes with hydrophobic molecules or covalent bonds with large structures to generate new materials. The present work aims to gather and integrate recent data from in vitro and in vivo preclinical studies of CD-based stimuli- responsive systems to contribute to the research in treating breast cancer. All drug carriers showed high in vitro release rates in the presence of a stimulus. The stimuli-responsive nanoplatforms presented biocompatibility and satisfactory results of IC50, inhibition of cell viability and antitumor activity against several breast cancer cell lines. Additionally, these systems led to a significant reduction in drug dosages, which encouraged possible clinical studies for better alternatives to traditional antitumor therapies.
publishDate 2024
dc.date.none.fl_str_mv 2024-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/257687
Nunes, Adenia Mirela Alves; de Oliveira Alves Júnior, José; Springer, Valeria Haydee; Júnior, João Augusto Oshiro; Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer; Bentham Science Publishers; Current Pharmaceutical Design; 30; 30; 8-2024; 2345-2363
1381-6128
CONICET Digital
CONICET
url http://hdl.handle.net/11336/257687
identifier_str_mv Nunes, Adenia Mirela Alves; de Oliveira Alves Júnior, José; Springer, Valeria Haydee; Júnior, João Augusto Oshiro; Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer; Bentham Science Publishers; Current Pharmaceutical Design; 30; 30; 8-2024; 2345-2363
1381-6128
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.eurekaselect.com/231614/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/0113816128291108240613094515
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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