Inhibitory autapse mediates anticipated synchronization between coupled neurons

Autores
Pinto, Marcel A.; Rosso, Osvaldo Aníbal; Matias, Fernanda S.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Two identical autonomous dynamical systems unidirectionally coupled in a sender-receiver configuration can exhibit anticipated synchronization (AS) if the Receiver neuron (R) also receives a delayed negative self-feedback. Recently, AS was shown to occur in a three-neuron motif with standard chemical synapses where the delayed inhibition was provided by an interneuron. Here we show that a two-neuron model in the presence of an inhibitory autapse, which is a massive self-innervation present in the cortical architecture, may present AS. The GABAergic autapse regulates the internal dynamics of the Receiver neuron and acts as the negative delayed self-feedback required by dynamical systems in order to exhibit AS. In this biologically plausible scenario, a smooth transition from the usual delayed synchronization (DS) to AS typically occurs when the inhibitory conductance is increased. The phenomenon is shown to be robust when model parameters are varied within a physiological range. For extremely large values of the inhibitory autapse the system undergoes to a phase-drift regime in which the Receiver is faster than the Sender. Furthermore, we show that the inhibitory autapse promotes a faster internal dynamics of the free-running Receiver when the two neurons are uncoupled, which could be the mechanism underlying anticipated synchronization and the DS-AS transition.
Fil: Pinto, Marcel A.. Universidade Federal de Alagoas; Brasil
Fil: Rosso, Osvaldo Aníbal. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Departamento de Informática En Salud.; Argentina. Universidade Federal de Alagoas; Brasil. Universidad de Los Andes. Facultad de Medicina.; Chile
Fil: Matias, Fernanda S.. Universidade Federal de Alagoas; Brasil
Materia
NEURONAL DYNAMICS
ANTICIPATED SYNCHRONIZATION
INHIBITORY AUTAPSE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/110598
Acceder
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spelling Inhibitory autapse mediates anticipated synchronization between coupled neuronsPinto, Marcel A.Rosso, Osvaldo AníbalMatias, Fernanda S.NEURONAL DYNAMICSANTICIPATED SYNCHRONIZATIONINHIBITORY AUTAPSEhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Two identical autonomous dynamical systems unidirectionally coupled in a sender-receiver configuration can exhibit anticipated synchronization (AS) if the Receiver neuron (R) also receives a delayed negative self-feedback. Recently, AS was shown to occur in a three-neuron motif with standard chemical synapses where the delayed inhibition was provided by an interneuron. Here we show that a two-neuron model in the presence of an inhibitory autapse, which is a massive self-innervation present in the cortical architecture, may present AS. The GABAergic autapse regulates the internal dynamics of the Receiver neuron and acts as the negative delayed self-feedback required by dynamical systems in order to exhibit AS. In this biologically plausible scenario, a smooth transition from the usual delayed synchronization (DS) to AS typically occurs when the inhibitory conductance is increased. The phenomenon is shown to be robust when model parameters are varied within a physiological range. For extremely large values of the inhibitory autapse the system undergoes to a phase-drift regime in which the Receiver is faster than the Sender. Furthermore, we show that the inhibitory autapse promotes a faster internal dynamics of the free-running Receiver when the two neurons are uncoupled, which could be the mechanism underlying anticipated synchronization and the DS-AS transition.Fil: Pinto, Marcel A.. Universidade Federal de Alagoas; BrasilFil: Rosso, Osvaldo Aníbal. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Departamento de Informática En Salud.; Argentina. Universidade Federal de Alagoas; Brasil. Universidad de Los Andes. Facultad de Medicina.; ChileFil: Matias, Fernanda S.. Universidade Federal de Alagoas; BrasilAmerican Physical Society2019-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/110598Pinto, Marcel A.; Rosso, Osvaldo Aníbal; Matias, Fernanda S.; Inhibitory autapse mediates anticipated synchronization between coupled neurons; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 99; 6; 6-2019; 1-62470-0053CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.99.062411info:eu-repo/semantics/altIdentifier/url/https://journals.aps.org/pre/abstract/10.1103/PhysRevE.99.062411info:eu-repo/semantics/altIdentifier/url/https://arxiv.org/abs/1906.03066info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:32:54Zoai:ri.conicet.gov.ar:11336/110598instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:32:54.824CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inhibitory autapse mediates anticipated synchronization between coupled neurons
title Inhibitory autapse mediates anticipated synchronization between coupled neurons
spellingShingle Inhibitory autapse mediates anticipated synchronization between coupled neurons
Pinto, Marcel A.
NEURONAL DYNAMICS
ANTICIPATED SYNCHRONIZATION
INHIBITORY AUTAPSE
title_short Inhibitory autapse mediates anticipated synchronization between coupled neurons
title_full Inhibitory autapse mediates anticipated synchronization between coupled neurons
title_fullStr Inhibitory autapse mediates anticipated synchronization between coupled neurons
title_full_unstemmed Inhibitory autapse mediates anticipated synchronization between coupled neurons
title_sort Inhibitory autapse mediates anticipated synchronization between coupled neurons
dc.creator.none.fl_str_mv Pinto, Marcel A.
Rosso, Osvaldo Aníbal
Matias, Fernanda S.
author Pinto, Marcel A.
author_facet Pinto, Marcel A.
Rosso, Osvaldo Aníbal
Matias, Fernanda S.
author_role author
author2 Rosso, Osvaldo Aníbal
Matias, Fernanda S.
author2_role author
author
dc.subject.none.fl_str_mv NEURONAL DYNAMICS
ANTICIPATED SYNCHRONIZATION
INHIBITORY AUTAPSE
topic NEURONAL DYNAMICS
ANTICIPATED SYNCHRONIZATION
INHIBITORY AUTAPSE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Two identical autonomous dynamical systems unidirectionally coupled in a sender-receiver configuration can exhibit anticipated synchronization (AS) if the Receiver neuron (R) also receives a delayed negative self-feedback. Recently, AS was shown to occur in a three-neuron motif with standard chemical synapses where the delayed inhibition was provided by an interneuron. Here we show that a two-neuron model in the presence of an inhibitory autapse, which is a massive self-innervation present in the cortical architecture, may present AS. The GABAergic autapse regulates the internal dynamics of the Receiver neuron and acts as the negative delayed self-feedback required by dynamical systems in order to exhibit AS. In this biologically plausible scenario, a smooth transition from the usual delayed synchronization (DS) to AS typically occurs when the inhibitory conductance is increased. The phenomenon is shown to be robust when model parameters are varied within a physiological range. For extremely large values of the inhibitory autapse the system undergoes to a phase-drift regime in which the Receiver is faster than the Sender. Furthermore, we show that the inhibitory autapse promotes a faster internal dynamics of the free-running Receiver when the two neurons are uncoupled, which could be the mechanism underlying anticipated synchronization and the DS-AS transition.
Fil: Pinto, Marcel A.. Universidade Federal de Alagoas; Brasil
Fil: Rosso, Osvaldo Aníbal. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano. Departamento de Informática En Salud.; Argentina. Universidade Federal de Alagoas; Brasil. Universidad de Los Andes. Facultad de Medicina.; Chile
Fil: Matias, Fernanda S.. Universidade Federal de Alagoas; Brasil
description Two identical autonomous dynamical systems unidirectionally coupled in a sender-receiver configuration can exhibit anticipated synchronization (AS) if the Receiver neuron (R) also receives a delayed negative self-feedback. Recently, AS was shown to occur in a three-neuron motif with standard chemical synapses where the delayed inhibition was provided by an interneuron. Here we show that a two-neuron model in the presence of an inhibitory autapse, which is a massive self-innervation present in the cortical architecture, may present AS. The GABAergic autapse regulates the internal dynamics of the Receiver neuron and acts as the negative delayed self-feedback required by dynamical systems in order to exhibit AS. In this biologically plausible scenario, a smooth transition from the usual delayed synchronization (DS) to AS typically occurs when the inhibitory conductance is increased. The phenomenon is shown to be robust when model parameters are varied within a physiological range. For extremely large values of the inhibitory autapse the system undergoes to a phase-drift regime in which the Receiver is faster than the Sender. Furthermore, we show that the inhibitory autapse promotes a faster internal dynamics of the free-running Receiver when the two neurons are uncoupled, which could be the mechanism underlying anticipated synchronization and the DS-AS transition.
publishDate 2019
dc.date.none.fl_str_mv 2019-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/110598
Pinto, Marcel A.; Rosso, Osvaldo Aníbal; Matias, Fernanda S.; Inhibitory autapse mediates anticipated synchronization between coupled neurons; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 99; 6; 6-2019; 1-6
2470-0053
CONICET Digital
CONICET
url http://hdl.handle.net/11336/110598
identifier_str_mv Pinto, Marcel A.; Rosso, Osvaldo Aníbal; Matias, Fernanda S.; Inhibitory autapse mediates anticipated synchronization between coupled neurons; American Physical Society; Physical Review E: Statistical, Nonlinear and Soft Matter Physics; 99; 6; 6-2019; 1-6
2470-0053
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevE.99.062411
info:eu-repo/semantics/altIdentifier/url/https://journals.aps.org/pre/abstract/10.1103/PhysRevE.99.062411
info:eu-repo/semantics/altIdentifier/url/https://arxiv.org/abs/1906.03066
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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