Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin

Autores
Lamdan Ordas, Humberto; Garcia Lazaro, Rocio Soledad; Lorenzo Pérez, Norailys; Caligiuri, Lorena Gisel; Alonso, Daniel Fernando; Farina, Hernán Gabriel
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim:In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. Key Words: anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols.
Fil: Lamdan Ordas, Humberto. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Garcia Lazaro, Rocio Soledad. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lorenzo Pérez, Norailys. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Caligiuri, Lorena Gisel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
ANTHOCYANINS
ANTI-PROLIFERATIVE
BLUEBERRY EXTRACT
CANCER
POLYPHENOLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/169142
Acceder
id CONICETDig_9341b8a96fe51bb11903b0f7f5c10f3a
oai_identifier_str oai:ri.conicet.gov.ar:11336/169142
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different originLamdan Ordas, HumbertoGarcia Lazaro, Rocio SoledadLorenzo Pérez, NorailysCaligiuri, Lorena GiselAlonso, Daniel FernandoFarina, Hernán GabrielANTHOCYANINSANTI-PROLIFERATIVEBLUEBERRY EXTRACTCANCERPOLYPHENOLShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim:In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. Key Words: anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols.Fil: Lamdan Ordas, Humberto. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; ArgentinaFil: Garcia Lazaro, Rocio Soledad. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lorenzo Pérez, Norailys. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; ArgentinaFil: Caligiuri, Lorena Gisel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; ArgentinaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMorion2020-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169142Lamdan Ordas, Humberto; Garcia Lazaro, Rocio Soledad; Lorenzo Pérez, Norailys; Caligiuri, Lorena Gisel; Alonso, Daniel Fernando; et al.; Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin; Morion; Experimental oncology; 42; 2; 6-2020; 101-1081812-92692312-8852CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/ 10.32471/clinicaloncology.2663-466X.36-4.14766info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:25:28Zoai:ri.conicet.gov.ar:11336/169142instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:25:29.254CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
title Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
spellingShingle Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
Lamdan Ordas, Humberto
ANTHOCYANINS
ANTI-PROLIFERATIVE
BLUEBERRY EXTRACT
CANCER
POLYPHENOLS
title_short Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
title_full Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
title_fullStr Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
title_full_unstemmed Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
title_sort Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
dc.creator.none.fl_str_mv Lamdan Ordas, Humberto
Garcia Lazaro, Rocio Soledad
Lorenzo Pérez, Norailys
Caligiuri, Lorena Gisel
Alonso, Daniel Fernando
Farina, Hernán Gabriel
author Lamdan Ordas, Humberto
author_facet Lamdan Ordas, Humberto
Garcia Lazaro, Rocio Soledad
Lorenzo Pérez, Norailys
Caligiuri, Lorena Gisel
Alonso, Daniel Fernando
Farina, Hernán Gabriel
author_role author
author2 Garcia Lazaro, Rocio Soledad
Lorenzo Pérez, Norailys
Caligiuri, Lorena Gisel
Alonso, Daniel Fernando
Farina, Hernán Gabriel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANTHOCYANINS
ANTI-PROLIFERATIVE
BLUEBERRY EXTRACT
CANCER
POLYPHENOLS
topic ANTHOCYANINS
ANTI-PROLIFERATIVE
BLUEBERRY EXTRACT
CANCER
POLYPHENOLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim:In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. Key Words: anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols.
Fil: Lamdan Ordas, Humberto. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Garcia Lazaro, Rocio Soledad. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lorenzo Pérez, Norailys. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Caligiuri, Lorena Gisel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim:In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. Key Words: anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols.
publishDate 2020
dc.date.none.fl_str_mv 2020-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/169142
Lamdan Ordas, Humberto; Garcia Lazaro, Rocio Soledad; Lorenzo Pérez, Norailys; Caligiuri, Lorena Gisel; Alonso, Daniel Fernando; et al.; Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin; Morion; Experimental oncology; 42; 2; 6-2020; 101-108
1812-9269
2312-8852
CONICET Digital
CONICET
url http://hdl.handle.net/11336/169142
identifier_str_mv Lamdan Ordas, Humberto; Garcia Lazaro, Rocio Soledad; Lorenzo Pérez, Norailys; Caligiuri, Lorena Gisel; Alonso, Daniel Fernando; et al.; Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin; Morion; Experimental oncology; 42; 2; 6-2020; 101-108
1812-9269
2312-8852
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/ 10.32471/clinicaloncology.2663-466X.36-4.14766
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Morion
publisher.none.fl_str_mv Morion
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781804246204416
score 13.179806

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