Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin
- Autores
- Lamdan Ordas, Humberto; Garcia Lazaro, Rocio Soledad; Lorenzo Pérez, Norailys; Caligiuri, Lorena Gisel; Alonso, Daniel Fernando; Farina, Hernán Gabriel
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim:In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. Key Words: anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols.
Fil: Lamdan Ordas, Humberto. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Garcia Lazaro, Rocio Soledad. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Lorenzo Pérez, Norailys. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Caligiuri, Lorena Gisel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina
Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
ANTHOCYANINS
ANTI-PROLIFERATIVE
BLUEBERRY EXTRACT
CANCER
POLYPHENOLS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/169142
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different originLamdan Ordas, HumbertoGarcia Lazaro, Rocio SoledadLorenzo Pérez, NorailysCaligiuri, Lorena GiselAlonso, Daniel FernandoFarina, Hernán GabrielANTHOCYANINSANTI-PROLIFERATIVEBLUEBERRY EXTRACTCANCERPOLYPHENOLShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim:In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. Key Words: anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols.Fil: Lamdan Ordas, Humberto. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; ArgentinaFil: Garcia Lazaro, Rocio Soledad. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lorenzo Pérez, Norailys. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; ArgentinaFil: Caligiuri, Lorena Gisel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; ArgentinaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaMorion2020-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169142Lamdan Ordas, Humberto; Garcia Lazaro, Rocio Soledad; Lorenzo Pérez, Norailys; Caligiuri, Lorena Gisel; Alonso, Daniel Fernando; et al.; Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin; Morion; Experimental oncology; 42; 2; 6-2020; 101-1081812-92692312-8852CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/ 10.32471/clinicaloncology.2663-466X.36-4.14766info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:25:28Zoai:ri.conicet.gov.ar:11336/169142instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:25:29.254CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
title |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
spellingShingle |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin Lamdan Ordas, Humberto ANTHOCYANINS ANTI-PROLIFERATIVE BLUEBERRY EXTRACT CANCER POLYPHENOLS |
title_short |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
title_full |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
title_fullStr |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
title_full_unstemmed |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
title_sort |
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin |
dc.creator.none.fl_str_mv |
Lamdan Ordas, Humberto Garcia Lazaro, Rocio Soledad Lorenzo Pérez, Norailys Caligiuri, Lorena Gisel Alonso, Daniel Fernando Farina, Hernán Gabriel |
author |
Lamdan Ordas, Humberto |
author_facet |
Lamdan Ordas, Humberto Garcia Lazaro, Rocio Soledad Lorenzo Pérez, Norailys Caligiuri, Lorena Gisel Alonso, Daniel Fernando Farina, Hernán Gabriel |
author_role |
author |
author2 |
Garcia Lazaro, Rocio Soledad Lorenzo Pérez, Norailys Caligiuri, Lorena Gisel Alonso, Daniel Fernando Farina, Hernán Gabriel |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
ANTHOCYANINS ANTI-PROLIFERATIVE BLUEBERRY EXTRACT CANCER POLYPHENOLS |
topic |
ANTHOCYANINS ANTI-PROLIFERATIVE BLUEBERRY EXTRACT CANCER POLYPHENOLS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim:In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. Key Words: anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols. Fil: Lamdan Ordas, Humberto. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina Fil: Garcia Lazaro, Rocio Soledad. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Lorenzo Pérez, Norailys. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina Fil: Caligiuri, Lorena Gisel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina Fil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Oncología Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
Background: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim:In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro. Key Words: anthocyanins, anti-proliferative, blueberry extract, cancer, polyphenols. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/169142 Lamdan Ordas, Humberto; Garcia Lazaro, Rocio Soledad; Lorenzo Pérez, Norailys; Caligiuri, Lorena Gisel; Alonso, Daniel Fernando; et al.; Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin; Morion; Experimental oncology; 42; 2; 6-2020; 101-108 1812-9269 2312-8852 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/169142 |
identifier_str_mv |
Lamdan Ordas, Humberto; Garcia Lazaro, Rocio Soledad; Lorenzo Pérez, Norailys; Caligiuri, Lorena Gisel; Alonso, Daniel Fernando; et al.; Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin; Morion; Experimental oncology; 42; 2; 6-2020; 101-108 1812-9269 2312-8852 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/ info:eu-repo/semantics/altIdentifier/doi/ 10.32471/clinicaloncology.2663-466X.36-4.14766 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Morion |
publisher.none.fl_str_mv |
Morion |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.179806 |