Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics

Autores
Wojnacki Fonseca, José Ignacio; Quassollo Infanzon, Gonzalo Emiliano; Marzolo, Maria Paz; Caceres, Alfredo Oscar
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Microtubule (MT) organization and dynamics downstream of external cues is crucial for maintaining cellular architecture and the generation of cell asymmetries. In interphase cells RhoA, Rac, and Cdc42, conspicuous members of the family of small Rho GTPases, have major roles in modulating MT stability, and hence polarized cell behaviors. However, MTs are not mere targets of Rho GTPases, but also serve as signaling platforms coupling MT dynamics to Rho GTPase activation in a variety of cellular conditions. In this article, we review some of the key studies describing the reciprocal relationship between small Rho-GTPases and MTs during migration and polarization.
Fil: Wojnacki Fonseca, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Quassollo Infanzon, Gonzalo Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Marzolo, Maria Paz. Pontificia Universidad Católica de Chile; Chile
Fil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
Microtubules
Stabilization
Actin Filaments
Small Gtpases
Protrusion
Migration
Polarity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/31642
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/31642
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamicsWojnacki Fonseca, José IgnacioQuassollo Infanzon, Gonzalo EmilianoMarzolo, Maria PazCaceres, Alfredo OscarMicrotubulesStabilizationActin FilamentsSmall GtpasesProtrusionMigrationPolarityhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Microtubule (MT) organization and dynamics downstream of external cues is crucial for maintaining cellular architecture and the generation of cell asymmetries. In interphase cells RhoA, Rac, and Cdc42, conspicuous members of the family of small Rho GTPases, have major roles in modulating MT stability, and hence polarized cell behaviors. However, MTs are not mere targets of Rho GTPases, but also serve as signaling platforms coupling MT dynamics to Rho GTPase activation in a variety of cellular conditions. In this article, we review some of the key studies describing the reciprocal relationship between small Rho-GTPases and MTs during migration and polarization.Fil: Wojnacki Fonseca, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Quassollo Infanzon, Gonzalo Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Marzolo, Maria Paz. Pontificia Universidad Católica de Chile; ChileFil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaLandes Bioscience2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/31642Quassollo Infanzon, Gonzalo Emiliano; Caceres, Alfredo Oscar; Marzolo, Maria Paz; Wojnacki Fonseca, José Ignacio; Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics; Landes Bioscience; Small GTPases; 5; 1; 3-2014; e284301-e2843092154-1248CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.4161/sgtp.28430info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/sgtp.28430info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:36:27Zoai:ri.conicet.gov.ar:11336/31642instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:36:28.025CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics
title Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics
spellingShingle Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics
Wojnacki Fonseca, José Ignacio
Microtubules
Stabilization
Actin Filaments
Small Gtpases
Protrusion
Migration
Polarity
title_short Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics
title_full Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics
title_fullStr Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics
title_full_unstemmed Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics
title_sort Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics
dc.creator.none.fl_str_mv Wojnacki Fonseca, José Ignacio
Quassollo Infanzon, Gonzalo Emiliano
Marzolo, Maria Paz
Caceres, Alfredo Oscar
author Wojnacki Fonseca, José Ignacio
author_facet Wojnacki Fonseca, José Ignacio
Quassollo Infanzon, Gonzalo Emiliano
Marzolo, Maria Paz
Caceres, Alfredo Oscar
author_role author
author2 Quassollo Infanzon, Gonzalo Emiliano
Marzolo, Maria Paz
Caceres, Alfredo Oscar
author2_role author
author
author
dc.subject.none.fl_str_mv Microtubules
Stabilization
Actin Filaments
Small Gtpases
Protrusion
Migration
Polarity
topic Microtubules
Stabilization
Actin Filaments
Small Gtpases
Protrusion
Migration
Polarity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Microtubule (MT) organization and dynamics downstream of external cues is crucial for maintaining cellular architecture and the generation of cell asymmetries. In interphase cells RhoA, Rac, and Cdc42, conspicuous members of the family of small Rho GTPases, have major roles in modulating MT stability, and hence polarized cell behaviors. However, MTs are not mere targets of Rho GTPases, but also serve as signaling platforms coupling MT dynamics to Rho GTPase activation in a variety of cellular conditions. In this article, we review some of the key studies describing the reciprocal relationship between small Rho-GTPases and MTs during migration and polarization.
Fil: Wojnacki Fonseca, José Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Quassollo Infanzon, Gonzalo Emiliano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Marzolo, Maria Paz. Pontificia Universidad Católica de Chile; Chile
Fil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description Microtubule (MT) organization and dynamics downstream of external cues is crucial for maintaining cellular architecture and the generation of cell asymmetries. In interphase cells RhoA, Rac, and Cdc42, conspicuous members of the family of small Rho GTPases, have major roles in modulating MT stability, and hence polarized cell behaviors. However, MTs are not mere targets of Rho GTPases, but also serve as signaling platforms coupling MT dynamics to Rho GTPase activation in a variety of cellular conditions. In this article, we review some of the key studies describing the reciprocal relationship between small Rho-GTPases and MTs during migration and polarization.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/31642
Quassollo Infanzon, Gonzalo Emiliano; Caceres, Alfredo Oscar; Marzolo, Maria Paz; Wojnacki Fonseca, José Ignacio; Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics; Landes Bioscience; Small GTPases; 5; 1; 3-2014; e284301-e284309
2154-1248
CONICET Digital
CONICET
url http://hdl.handle.net/11336/31642
identifier_str_mv Quassollo Infanzon, Gonzalo Emiliano; Caceres, Alfredo Oscar; Marzolo, Maria Paz; Wojnacki Fonseca, José Ignacio; Rho GTPases at the cross road of signaling networks in mammals. Impact of RhoGTPases on microtubule organization and dynamics; Landes Bioscience; Small GTPases; 5; 1; 3-2014; e284301-e284309
2154-1248
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4161/sgtp.28430
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/sgtp.28430
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782006011101184
score 12.982451

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