Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients

Autores
Rumbo, Carolina; Martínez, María Inés; Cabanne, Ana; Trentadue, Julio; Fernández, Adriana; Gondolesi, Gabriel Eduardo
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: Intestinal failure-associated liver disease (IFALD) is a frequent indication for intestinal transplantation. Liver biopsy (LBX) is the gold standard test for its diagnosis. Identifying noninvasive markers of fibrosis progression would be of considerable clinical use. Aspartate aminotransferase/platelet ratio index (APRI) has a good correlation in adult patients with chronic liver disease; few studies have been performed in children with IFALD.AIM:To evaluate APRI in a cohort of children with IFALD. MATERIALS AND METHODS: Retrospective analysis of a prospective database of patients <18 years with severe intestinal failure and at least 1 LBX, registered in our unit from March 2006 to December 2014. RESULTS: Forty-nine LBX were done on 36 patients: 20 were male, and 31 had short gut. Fibrosis was found in 71% of LBX. Biopsies were grouped according to the fibrosis stage (METAVIR [M]): (1) group 1 (G1) LBX with M 0, 1, 2 (n = 33) and (2) group 2 (G2) LBX with M 3, 4 (n = 16). The median APRI score was 0.92 (interquartile range [IQR] 0.63-1.50) for G1 and 2.50 (IQR 1.81-5.82) for G2 (P = .001) The c statistic of the receiving operating characteristic curve was 0.79 (95% CI 0.64-0.94; P < .001). The analyses allowed identifying a cutoff value for APRI of 1.6 as the point with the best sensitivity (81%) and specificity (76%) to predict advanced fibrosis. CONCLUSIONS: APRI in this cohort of patients shows that a score >1.6 correlates with advanced fibrosis.
Fil: Rumbo, Carolina. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Martínez, María Inés. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Cabanne, Ana. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Trentadue, Julio. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Fernández, Adriana. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Gondolesi, Gabriel Eduardo. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Apri
Intestinal Failure
Parenteral Nutrition
Liver Fibrosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42392
Acceder
id CONICETDig_9151c1a4ef56ca5c1d9cfeb7c12224d7
oai_identifier_str oai:ri.conicet.gov.ar:11336/42392
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric PatientsRumbo, CarolinaMartínez, María InésCabanne, AnaTrentadue, JulioFernández, AdrianaGondolesi, Gabriel EduardoApriIntestinal FailureParenteral NutritionLiver Fibrosishttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3BACKGROUND: Intestinal failure-associated liver disease (IFALD) is a frequent indication for intestinal transplantation. Liver biopsy (LBX) is the gold standard test for its diagnosis. Identifying noninvasive markers of fibrosis progression would be of considerable clinical use. Aspartate aminotransferase/platelet ratio index (APRI) has a good correlation in adult patients with chronic liver disease; few studies have been performed in children with IFALD.AIM:To evaluate APRI in a cohort of children with IFALD. MATERIALS AND METHODS: Retrospective analysis of a prospective database of patients <18 years with severe intestinal failure and at least 1 LBX, registered in our unit from March 2006 to December 2014. RESULTS: Forty-nine LBX were done on 36 patients: 20 were male, and 31 had short gut. Fibrosis was found in 71% of LBX. Biopsies were grouped according to the fibrosis stage (METAVIR [M]): (1) group 1 (G1) LBX with M 0, 1, 2 (n = 33) and (2) group 2 (G2) LBX with M 3, 4 (n = 16). The median APRI score was 0.92 (interquartile range [IQR] 0.63-1.50) for G1 and 2.50 (IQR 1.81-5.82) for G2 (P = .001) The c statistic of the receiving operating characteristic curve was 0.79 (95% CI 0.64-0.94; P < .001). The analyses allowed identifying a cutoff value for APRI of 1.6 as the point with the best sensitivity (81%) and specificity (76%) to predict advanced fibrosis. CONCLUSIONS: APRI in this cohort of patients shows that a score >1.6 correlates with advanced fibrosis.Fil: Rumbo, Carolina. Universidad Favaloro; Argentina. Fundación Favaloro; ArgentinaFil: Martínez, María Inés. Universidad Favaloro; Argentina. Fundación Favaloro; ArgentinaFil: Cabanne, Ana. Universidad Favaloro; Argentina. Fundación Favaloro; ArgentinaFil: Trentadue, Julio. Universidad Favaloro; Argentina. Fundación Favaloro; ArgentinaFil: Fernández, Adriana. Universidad Favaloro; Argentina. Fundación Favaloro; ArgentinaFil: Gondolesi, Gabriel Eduardo. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaSAGE Publications2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42392Rumbo, Carolina; Martínez, María Inés; Cabanne, Ana; Trentadue, Julio; Fernández, Adriana; et al.; Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients; SAGE Publications; Journal of Parenteral and Enteral Nutrition; 41; 5; 1-2016; 884-8890148-6071CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1177/0148607115625779info:eu-repo/semantics/altIdentifier/doi/10.1177/0148607115625779info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:05:02Zoai:ri.conicet.gov.ar:11336/42392instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:05:03.024CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients
title Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients
spellingShingle Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients
Rumbo, Carolina
Apri
Intestinal Failure
Parenteral Nutrition
Liver Fibrosis
title_short Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients
title_full Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients
title_fullStr Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients
title_full_unstemmed Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients
title_sort Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients
dc.creator.none.fl_str_mv Rumbo, Carolina
Martínez, María Inés
Cabanne, Ana
Trentadue, Julio
Fernández, Adriana
Gondolesi, Gabriel Eduardo
author Rumbo, Carolina
author_facet Rumbo, Carolina
Martínez, María Inés
Cabanne, Ana
Trentadue, Julio
Fernández, Adriana
Gondolesi, Gabriel Eduardo
author_role author
author2 Martínez, María Inés
Cabanne, Ana
Trentadue, Julio
Fernández, Adriana
Gondolesi, Gabriel Eduardo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Apri
Intestinal Failure
Parenteral Nutrition
Liver Fibrosis
topic Apri
Intestinal Failure
Parenteral Nutrition
Liver Fibrosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND: Intestinal failure-associated liver disease (IFALD) is a frequent indication for intestinal transplantation. Liver biopsy (LBX) is the gold standard test for its diagnosis. Identifying noninvasive markers of fibrosis progression would be of considerable clinical use. Aspartate aminotransferase/platelet ratio index (APRI) has a good correlation in adult patients with chronic liver disease; few studies have been performed in children with IFALD.AIM:To evaluate APRI in a cohort of children with IFALD. MATERIALS AND METHODS: Retrospective analysis of a prospective database of patients <18 years with severe intestinal failure and at least 1 LBX, registered in our unit from March 2006 to December 2014. RESULTS: Forty-nine LBX were done on 36 patients: 20 were male, and 31 had short gut. Fibrosis was found in 71% of LBX. Biopsies were grouped according to the fibrosis stage (METAVIR [M]): (1) group 1 (G1) LBX with M 0, 1, 2 (n = 33) and (2) group 2 (G2) LBX with M 3, 4 (n = 16). The median APRI score was 0.92 (interquartile range [IQR] 0.63-1.50) for G1 and 2.50 (IQR 1.81-5.82) for G2 (P = .001) The c statistic of the receiving operating characteristic curve was 0.79 (95% CI 0.64-0.94; P < .001). The analyses allowed identifying a cutoff value for APRI of 1.6 as the point with the best sensitivity (81%) and specificity (76%) to predict advanced fibrosis. CONCLUSIONS: APRI in this cohort of patients shows that a score >1.6 correlates with advanced fibrosis.
Fil: Rumbo, Carolina. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Martínez, María Inés. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Cabanne, Ana. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Trentadue, Julio. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Fernández, Adriana. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina
Fil: Gondolesi, Gabriel Eduardo. Universidad Favaloro; Argentina. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description BACKGROUND: Intestinal failure-associated liver disease (IFALD) is a frequent indication for intestinal transplantation. Liver biopsy (LBX) is the gold standard test for its diagnosis. Identifying noninvasive markers of fibrosis progression would be of considerable clinical use. Aspartate aminotransferase/platelet ratio index (APRI) has a good correlation in adult patients with chronic liver disease; few studies have been performed in children with IFALD.AIM:To evaluate APRI in a cohort of children with IFALD. MATERIALS AND METHODS: Retrospective analysis of a prospective database of patients <18 years with severe intestinal failure and at least 1 LBX, registered in our unit from March 2006 to December 2014. RESULTS: Forty-nine LBX were done on 36 patients: 20 were male, and 31 had short gut. Fibrosis was found in 71% of LBX. Biopsies were grouped according to the fibrosis stage (METAVIR [M]): (1) group 1 (G1) LBX with M 0, 1, 2 (n = 33) and (2) group 2 (G2) LBX with M 3, 4 (n = 16). The median APRI score was 0.92 (interquartile range [IQR] 0.63-1.50) for G1 and 2.50 (IQR 1.81-5.82) for G2 (P = .001) The c statistic of the receiving operating characteristic curve was 0.79 (95% CI 0.64-0.94; P < .001). The analyses allowed identifying a cutoff value for APRI of 1.6 as the point with the best sensitivity (81%) and specificity (76%) to predict advanced fibrosis. CONCLUSIONS: APRI in this cohort of patients shows that a score >1.6 correlates with advanced fibrosis.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42392
Rumbo, Carolina; Martínez, María Inés; Cabanne, Ana; Trentadue, Julio; Fernández, Adriana; et al.; Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients; SAGE Publications; Journal of Parenteral and Enteral Nutrition; 41; 5; 1-2016; 884-889
0148-6071
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42392
identifier_str_mv Rumbo, Carolina; Martínez, María Inés; Cabanne, Ana; Trentadue, Julio; Fernández, Adriana; et al.; Utility of Aminotransferase/Platelet Ratio Index to Predict Liver Fibrosis in Intestinal Failure–Associated Liver Disease in Pediatric Patients; SAGE Publications; Journal of Parenteral and Enteral Nutrition; 41; 5; 1-2016; 884-889
0148-6071
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1177/0148607115625779
info:eu-repo/semantics/altIdentifier/doi/10.1177/0148607115625779
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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