Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual...

Autores
Pedrini, Nicolás
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Entomopathogenic fungi of the order Hypocreales infect their insect hosts mainly by penetrating through the cuticle and colonize them by proliferating throughout the body cavity. In order to ensure a successful infection, fungi first produce a variety of degrading enzymes that help to breach the insect cuticle, and then secrete toxic secondary metabolites that facilitate fungal invasion of the hemolymph. In response, insect hosts activate their innate immune system by triggering both cellular and humoral immune reactions. As fungi are exposed to stress in both cuticle and hemolymph, several mechanisms are activated not only to deal with this situation but also to mimic host epitopes and evade the insect's immune response. In this review, several components involved in the molecular interaction between insects and fungal pathogens are described including chemical, metabolomics, and dual transcriptomics approaches; with emphasis in the involvement of cuticle surface components in (pre-) infection processes, and fungal secondary metabolite (non-ribosomally synthesized peptides and polyketides) analysis. Some of the mechanisms involved in such interaction are also discussed.
Fil: Pedrini, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
Materia
Arms Race
Beauveria Bassiana
Coevolution
Dual Rna-Seq
Fungal Toxins
Metarhizium Anisopliae
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/57417
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studiesPedrini, NicolásArms RaceBeauveria BassianaCoevolutionDual Rna-SeqFungal ToxinsMetarhizium Anisopliaehttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Entomopathogenic fungi of the order Hypocreales infect their insect hosts mainly by penetrating through the cuticle and colonize them by proliferating throughout the body cavity. In order to ensure a successful infection, fungi first produce a variety of degrading enzymes that help to breach the insect cuticle, and then secrete toxic secondary metabolites that facilitate fungal invasion of the hemolymph. In response, insect hosts activate their innate immune system by triggering both cellular and humoral immune reactions. As fungi are exposed to stress in both cuticle and hemolymph, several mechanisms are activated not only to deal with this situation but also to mimic host epitopes and evade the insect's immune response. In this review, several components involved in the molecular interaction between insects and fungal pathogens are described including chemical, metabolomics, and dual transcriptomics approaches; with emphasis in the involvement of cuticle surface components in (pre-) infection processes, and fungal secondary metabolite (non-ribosomally synthesized peptides and polyketides) analysis. Some of the mechanisms involved in such interaction are also discussed.Fil: Pedrini, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaElsevier2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57417Pedrini, Nicolás; Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies; Elsevier; Fungal Biology; 122; 6; 6-2018; 538-5451878-6146CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.funbio.2017.10.003info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S187861461730140Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:36Zoai:ri.conicet.gov.ar:11336/57417instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:36.844CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies
title Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies
spellingShingle Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies
Pedrini, Nicolás
Arms Race
Beauveria Bassiana
Coevolution
Dual Rna-Seq
Fungal Toxins
Metarhizium Anisopliae
title_short Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies
title_full Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies
title_fullStr Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies
title_full_unstemmed Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies
title_sort Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies
dc.creator.none.fl_str_mv Pedrini, Nicolás
author Pedrini, Nicolás
author_facet Pedrini, Nicolás
author_role author
dc.subject.none.fl_str_mv Arms Race
Beauveria Bassiana
Coevolution
Dual Rna-Seq
Fungal Toxins
Metarhizium Anisopliae
topic Arms Race
Beauveria Bassiana
Coevolution
Dual Rna-Seq
Fungal Toxins
Metarhizium Anisopliae
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Entomopathogenic fungi of the order Hypocreales infect their insect hosts mainly by penetrating through the cuticle and colonize them by proliferating throughout the body cavity. In order to ensure a successful infection, fungi first produce a variety of degrading enzymes that help to breach the insect cuticle, and then secrete toxic secondary metabolites that facilitate fungal invasion of the hemolymph. In response, insect hosts activate their innate immune system by triggering both cellular and humoral immune reactions. As fungi are exposed to stress in both cuticle and hemolymph, several mechanisms are activated not only to deal with this situation but also to mimic host epitopes and evade the insect's immune response. In this review, several components involved in the molecular interaction between insects and fungal pathogens are described including chemical, metabolomics, and dual transcriptomics approaches; with emphasis in the involvement of cuticle surface components in (pre-) infection processes, and fungal secondary metabolite (non-ribosomally synthesized peptides and polyketides) analysis. Some of the mechanisms involved in such interaction are also discussed.
Fil: Pedrini, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; Argentina
description Entomopathogenic fungi of the order Hypocreales infect their insect hosts mainly by penetrating through the cuticle and colonize them by proliferating throughout the body cavity. In order to ensure a successful infection, fungi first produce a variety of degrading enzymes that help to breach the insect cuticle, and then secrete toxic secondary metabolites that facilitate fungal invasion of the hemolymph. In response, insect hosts activate their innate immune system by triggering both cellular and humoral immune reactions. As fungi are exposed to stress in both cuticle and hemolymph, several mechanisms are activated not only to deal with this situation but also to mimic host epitopes and evade the insect's immune response. In this review, several components involved in the molecular interaction between insects and fungal pathogens are described including chemical, metabolomics, and dual transcriptomics approaches; with emphasis in the involvement of cuticle surface components in (pre-) infection processes, and fungal secondary metabolite (non-ribosomally synthesized peptides and polyketides) analysis. Some of the mechanisms involved in such interaction are also discussed.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/57417
Pedrini, Nicolás; Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies; Elsevier; Fungal Biology; 122; 6; 6-2018; 538-545
1878-6146
CONICET Digital
CONICET
url http://hdl.handle.net/11336/57417
identifier_str_mv Pedrini, Nicolás; Molecular interactions between entomopathogenic fungi (Hypocreales) and their insect host: Perspectives from stressful cuticle and hemolymph battlefields and the potential of dual RNA sequencing for future studies; Elsevier; Fungal Biology; 122; 6; 6-2018; 538-545
1878-6146
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.funbio.2017.10.003
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S187861461730140X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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