Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm

Autores
Meini, María Rocío; Gonzalez, Lisandro Javier; Vila, Alejandro Jose
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Zn(II) is an essential metal ion in living organisms, playing a wide variety of roles as a structural, regulatory or catalytic cofactor in proteins, that is able to interact with approximately 10% of the entire proteome in humans [1]. As is the case for most transition metal ions, high Zn(II) levels are toxic. Therefore, organisms have developed a series of mechanisms to regulate Zn(II) concentrations and to ensure proper metal uptake by metalloproteins [2]. These mechanisms involve specific metal sensor proteins, import and export machineries that allow subcellular compartmentalization and a pool of small molecules and/or proteins that are able to bind excess Zn(II) [2]. As a result, there is rarely free Zn(II) within cells and biological fluids [3].
Fil: Meini, María Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Gonzalez, Lisandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Materia
ANTIBIOTIC RESISTANCE
NUTRITIONAL IMMUNITY
PERIPLASM
ZN(II)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94275
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasmMeini, María RocíoGonzalez, Lisandro JavierVila, Alejandro JoseANTIBIOTIC RESISTANCENUTRITIONAL IMMUNITYPERIPLASMZN(II)https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Zn(II) is an essential metal ion in living organisms, playing a wide variety of roles as a structural, regulatory or catalytic cofactor in proteins, that is able to interact with approximately 10% of the entire proteome in humans [1]. As is the case for most transition metal ions, high Zn(II) levels are toxic. Therefore, organisms have developed a series of mechanisms to regulate Zn(II) concentrations and to ensure proper metal uptake by metalloproteins [2]. These mechanisms involve specific metal sensor proteins, import and export machineries that allow subcellular compartmentalization and a pool of small molecules and/or proteins that are able to bind excess Zn(II) [2]. As a result, there is rarely free Zn(II) within cells and biological fluids [3].Fil: Meini, María Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Gonzalez, Lisandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; ArgentinaFuture Medicine2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94275Meini, María Rocío; Gonzalez, Lisandro Javier; Vila, Alejandro Jose; Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm; Future Medicine; Future Microbiology; 8; 8; 8-2013; 947-9491746-0913CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/full/10.2217/fmb.13.34info:eu-repo/semantics/altIdentifier/doi/10.2217/fmb.13.34info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:15:40Zoai:ri.conicet.gov.ar:11336/94275instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:15:41.173CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm
title Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm
spellingShingle Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm
Meini, María Rocío
ANTIBIOTIC RESISTANCE
NUTRITIONAL IMMUNITY
PERIPLASM
ZN(II)
title_short Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm
title_full Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm
title_fullStr Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm
title_full_unstemmed Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm
title_sort Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm
dc.creator.none.fl_str_mv Meini, María Rocío
Gonzalez, Lisandro Javier
Vila, Alejandro Jose
author Meini, María Rocío
author_facet Meini, María Rocío
Gonzalez, Lisandro Javier
Vila, Alejandro Jose
author_role author
author2 Gonzalez, Lisandro Javier
Vila, Alejandro Jose
author2_role author
author
dc.subject.none.fl_str_mv ANTIBIOTIC RESISTANCE
NUTRITIONAL IMMUNITY
PERIPLASM
ZN(II)
topic ANTIBIOTIC RESISTANCE
NUTRITIONAL IMMUNITY
PERIPLASM
ZN(II)
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Zn(II) is an essential metal ion in living organisms, playing a wide variety of roles as a structural, regulatory or catalytic cofactor in proteins, that is able to interact with approximately 10% of the entire proteome in humans [1]. As is the case for most transition metal ions, high Zn(II) levels are toxic. Therefore, organisms have developed a series of mechanisms to regulate Zn(II) concentrations and to ensure proper metal uptake by metalloproteins [2]. These mechanisms involve specific metal sensor proteins, import and export machineries that allow subcellular compartmentalization and a pool of small molecules and/or proteins that are able to bind excess Zn(II) [2]. As a result, there is rarely free Zn(II) within cells and biological fluids [3].
Fil: Meini, María Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Gonzalez, Lisandro Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
Fil: Vila, Alejandro Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Biología Molecular y Celular de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario; Argentina
description Zn(II) is an essential metal ion in living organisms, playing a wide variety of roles as a structural, regulatory or catalytic cofactor in proteins, that is able to interact with approximately 10% of the entire proteome in humans [1]. As is the case for most transition metal ions, high Zn(II) levels are toxic. Therefore, organisms have developed a series of mechanisms to regulate Zn(II) concentrations and to ensure proper metal uptake by metalloproteins [2]. These mechanisms involve specific metal sensor proteins, import and export machineries that allow subcellular compartmentalization and a pool of small molecules and/or proteins that are able to bind excess Zn(II) [2]. As a result, there is rarely free Zn(II) within cells and biological fluids [3].
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94275
Meini, María Rocío; Gonzalez, Lisandro Javier; Vila, Alejandro Jose; Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm; Future Medicine; Future Microbiology; 8; 8; 8-2013; 947-949
1746-0913
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94275
identifier_str_mv Meini, María Rocío; Gonzalez, Lisandro Javier; Vila, Alejandro Jose; Antibiotic resistance in Zn(II)-deficient environments: Metallo-β-lactamase activation in the periplasm; Future Medicine; Future Microbiology; 8; 8; 8-2013; 947-949
1746-0913
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/full/10.2217/fmb.13.34
info:eu-repo/semantics/altIdentifier/doi/10.2217/fmb.13.34
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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