A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Proper...

Autores
Ledesma, Gabriela Nanci; Eury, Hélène; Anxolabéhère Mallart, Elodie; Hureau, Christelle; Signorella, Sandra Rosanna
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A mononuclear MnIII complex MnL·4H2O (H3L = 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4- methylbenzyl)amino]propan-2-ol) has been prepared and characterized. This complex catalyzes the dismutation of superoxide efficiently, with catalytic rate constant kcat=1.7 × 106M−1 s−1 and IC50 1.26 μM, obtained through the nitro blue tetrazoliumphotoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. MnL is also able to disproportionate more than 300 equivalents of H2O2 in CH3CN, with initial rate of H2O2 decomposition given by ri=kcat [MnL]2 [H2O2]and kcat = 1.32 (2) mM−2 min−1. The accessibility of the MnIV state (Ep = 0.53 V vs. saturated calomel electrode), suggests MnL employs a high-valent catalytic cycle to decompose O2?− and H2O2.
Fil: Ledesma, Gabriela Nanci. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Eury, Hélène. Centre National de la Recherche Scientifique. Laboratoire de Chimie de Coordination; Francia
Fil: Anxolabéhère Mallart, Elodie. Universite de Toulose - Le Mirail; Francia
Fil: Hureau, Christelle. Laboratoire de Chimie de Coordination; Francia
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Materia
Mn Complex
Sod/Cat Activity
Kinetics
Mn-Based Ros Scavenger
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6130
Acceder
id CONICETDig_9009bda17a33292ba2f58b440a753bba
oai_identifier_str oai:ri.conicet.gov.ar:11336/6130
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics StudiesLedesma, Gabriela NanciEury, HélèneAnxolabéhère Mallart, ElodieHureau, ChristelleSignorella, Sandra RosannaMn ComplexSod/Cat ActivityKineticsMn-Based Ros Scavengerhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A mononuclear MnIII complex MnL·4H2O (H3L = 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4- methylbenzyl)amino]propan-2-ol) has been prepared and characterized. This complex catalyzes the dismutation of superoxide efficiently, with catalytic rate constant kcat=1.7 × 106M−1 s−1 and IC50 1.26 μM, obtained through the nitro blue tetrazoliumphotoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. MnL is also able to disproportionate more than 300 equivalents of H2O2 in CH3CN, with initial rate of H2O2 decomposition given by ri=kcat [MnL]2 [H2O2]and kcat = 1.32 (2) mM−2 min−1. The accessibility of the MnIV state (Ep = 0.53 V vs. saturated calomel electrode), suggests MnL employs a high-valent catalytic cycle to decompose O2?− and H2O2.Fil: Ledesma, Gabriela Nanci. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Eury, Hélène. Centre National de la Recherche Scientifique. Laboratoire de Chimie de Coordination; FranciaFil: Anxolabéhère Mallart, Elodie. Universite de Toulose - Le Mirail; FranciaFil: Hureau, Christelle. Laboratoire de Chimie de Coordination; FranciaFil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaElsevier2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6130Ledesma, Gabriela Nanci; Eury, Hélène; Anxolabéhère Mallart, Elodie; Hureau, Christelle; Signorella, Sandra Rosanna; A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies; Elsevier; Journal of Inorganic Biochemistry; 146; 3-2015; 69-760162-0134enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0162013415000550info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2015.02.012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:51Zoai:ri.conicet.gov.ar:11336/6130instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:51.609CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies
title A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies
spellingShingle A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies
Ledesma, Gabriela Nanci
Mn Complex
Sod/Cat Activity
Kinetics
Mn-Based Ros Scavenger
title_short A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies
title_full A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies
title_fullStr A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies
title_full_unstemmed A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies
title_sort A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies
dc.creator.none.fl_str_mv Ledesma, Gabriela Nanci
Eury, Hélène
Anxolabéhère Mallart, Elodie
Hureau, Christelle
Signorella, Sandra Rosanna
author Ledesma, Gabriela Nanci
author_facet Ledesma, Gabriela Nanci
Eury, Hélène
Anxolabéhère Mallart, Elodie
Hureau, Christelle
Signorella, Sandra Rosanna
author_role author
author2 Eury, Hélène
Anxolabéhère Mallart, Elodie
Hureau, Christelle
Signorella, Sandra Rosanna
author2_role author
author
author
author
dc.subject.none.fl_str_mv Mn Complex
Sod/Cat Activity
Kinetics
Mn-Based Ros Scavenger
topic Mn Complex
Sod/Cat Activity
Kinetics
Mn-Based Ros Scavenger
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A mononuclear MnIII complex MnL·4H2O (H3L = 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4- methylbenzyl)amino]propan-2-ol) has been prepared and characterized. This complex catalyzes the dismutation of superoxide efficiently, with catalytic rate constant kcat=1.7 × 106M−1 s−1 and IC50 1.26 μM, obtained through the nitro blue tetrazoliumphotoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. MnL is also able to disproportionate more than 300 equivalents of H2O2 in CH3CN, with initial rate of H2O2 decomposition given by ri=kcat [MnL]2 [H2O2]and kcat = 1.32 (2) mM−2 min−1. The accessibility of the MnIV state (Ep = 0.53 V vs. saturated calomel electrode), suggests MnL employs a high-valent catalytic cycle to decompose O2?− and H2O2.
Fil: Ledesma, Gabriela Nanci. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Eury, Hélène. Centre National de la Recherche Scientifique. Laboratoire de Chimie de Coordination; Francia
Fil: Anxolabéhère Mallart, Elodie. Universite de Toulose - Le Mirail; Francia
Fil: Hureau, Christelle. Laboratoire de Chimie de Coordination; Francia
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
description A mononuclear MnIII complex MnL·4H2O (H3L = 1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N′-(2-hydroxybenzyl),N′-(4- methylbenzyl)amino]propan-2-ol) has been prepared and characterized. This complex catalyzes the dismutation of superoxide efficiently, with catalytic rate constant kcat=1.7 × 106M−1 s−1 and IC50 1.26 μM, obtained through the nitro blue tetrazoliumphotoreduction inhibition superoxide dismutase assay, in aqueous solution of pH 7.8. MnL is also able to disproportionate more than 300 equivalents of H2O2 in CH3CN, with initial rate of H2O2 decomposition given by ri=kcat [MnL]2 [H2O2]and kcat = 1.32 (2) mM−2 min−1. The accessibility of the MnIV state (Ep = 0.53 V vs. saturated calomel electrode), suggests MnL employs a high-valent catalytic cycle to decompose O2?− and H2O2.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6130
Ledesma, Gabriela Nanci; Eury, Hélène; Anxolabéhère Mallart, Elodie; Hureau, Christelle; Signorella, Sandra Rosanna; A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies; Elsevier; Journal of Inorganic Biochemistry; 146; 3-2015; 69-76
0162-0134
url http://hdl.handle.net/11336/6130
identifier_str_mv Ledesma, Gabriela Nanci; Eury, Hélène; Anxolabéhère Mallart, Elodie; Hureau, Christelle; Signorella, Sandra Rosanna; A New Mononuclear Manganese(III) Complex of an Unsymmetrical Hexadentate N3O3 Ligand Exhibiting Superoxide Dismutase and Catalase-like Activity: Synthesis, Characterization, Properties and Kinetics Studies; Elsevier; Journal of Inorganic Biochemistry; 146; 3-2015; 69-76
0162-0134
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0162013415000550
info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2015.02.012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613081401917440
score 13.070432

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