Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome

Autores
Ferraris, J. R.; Ferraris, V.; Acquier, Andrea Beatriz; Sorroche, P. B.; Saez, M. S.; Ginaca, A.; Mendez, Carlos Fernando
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome.
Fil: Ferraris, J. R.. Hospital Italiano de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Ferraris, V.. Hospital Italiano de Buenos Aires; Argentina
Fil: Acquier, Andrea Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina
Fil: Sorroche, P. B.. Hospital Italiano de Buenos Aires; Argentina
Fil: Saez, M. S.. Hospital Italiano de Buenos Aires; Argentina
Fil: Ginaca, A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina
Fil: Mendez, Carlos Fernando. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina
Materia
Acute Renal Injury
Alternative Pathway
Complement
Hus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15194
Acceder
id CONICETDig_8fb7ae7e33ec0c38f50267e9435437ef
oai_identifier_str oai:ri.conicet.gov.ar:11336/15194
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndromeFerraris, J. R.Ferraris, V.Acquier, Andrea BeatrizSorroche, P. B.Saez, M. S.Ginaca, A.Mendez, Carlos FernandoAcute Renal InjuryAlternative PathwayComplementHushttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome.Fil: Ferraris, J. R.. Hospital Italiano de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Ferraris, V.. Hospital Italiano de Buenos Aires; ArgentinaFil: Acquier, Andrea Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; ArgentinaFil: Sorroche, P. B.. Hospital Italiano de Buenos Aires; ArgentinaFil: Saez, M. S.. Hospital Italiano de Buenos Aires; ArgentinaFil: Ginaca, A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; ArgentinaFil: Mendez, Carlos Fernando. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; ArgentinaWiley2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15194Ferraris, J. R.; Ferraris, V.; Acquier, Andrea Beatriz; Sorroche, P. B.; Saez, M. S.; et al.; Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome; Wiley; Clinical and Experimental Immunology; 181; 1; 6-2015; 118-1250009-91041365-2249enginfo:eu-repo/semantics/altIdentifier/doi/10.1111/cei.12601info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/cei.12601/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:27:56Zoai:ri.conicet.gov.ar:11336/15194instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:27:56.916CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
title Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
spellingShingle Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
Ferraris, J. R.
Acute Renal Injury
Alternative Pathway
Complement
Hus
title_short Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
title_full Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
title_fullStr Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
title_full_unstemmed Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
title_sort Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
dc.creator.none.fl_str_mv Ferraris, J. R.
Ferraris, V.
Acquier, Andrea Beatriz
Sorroche, P. B.
Saez, M. S.
Ginaca, A.
Mendez, Carlos Fernando
author Ferraris, J. R.
author_facet Ferraris, J. R.
Ferraris, V.
Acquier, Andrea Beatriz
Sorroche, P. B.
Saez, M. S.
Ginaca, A.
Mendez, Carlos Fernando
author_role author
author2 Ferraris, V.
Acquier, Andrea Beatriz
Sorroche, P. B.
Saez, M. S.
Ginaca, A.
Mendez, Carlos Fernando
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Acute Renal Injury
Alternative Pathway
Complement
Hus
topic Acute Renal Injury
Alternative Pathway
Complement
Hus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome.
Fil: Ferraris, J. R.. Hospital Italiano de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Ferraris, V.. Hospital Italiano de Buenos Aires; Argentina
Fil: Acquier, Andrea Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina
Fil: Sorroche, P. B.. Hospital Italiano de Buenos Aires; Argentina
Fil: Saez, M. S.. Hospital Italiano de Buenos Aires; Argentina
Fil: Ginaca, A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina
Fil: Mendez, Carlos Fernando. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina
description Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome.
publishDate 2015
dc.date.none.fl_str_mv 2015-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15194
Ferraris, J. R.; Ferraris, V.; Acquier, Andrea Beatriz; Sorroche, P. B.; Saez, M. S.; et al.; Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome; Wiley; Clinical and Experimental Immunology; 181; 1; 6-2015; 118-125
0009-9104
1365-2249
url http://hdl.handle.net/11336/15194
identifier_str_mv Ferraris, J. R.; Ferraris, V.; Acquier, Andrea Beatriz; Sorroche, P. B.; Saez, M. S.; et al.; Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome; Wiley; Clinical and Experimental Immunology; 181; 1; 6-2015; 118-125
0009-9104
1365-2249
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/cei.12601
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/cei.12601/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083420529098752
score 13.22299

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