Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome
- Autores
- Ferraris, J. R.; Ferraris, V.; Acquier, Andrea Beatriz; Sorroche, P. B.; Saez, M. S.; Ginaca, A.; Mendez, Carlos Fernando
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome.
Fil: Ferraris, J. R.. Hospital Italiano de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Ferraris, V.. Hospital Italiano de Buenos Aires; Argentina
Fil: Acquier, Andrea Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina
Fil: Sorroche, P. B.. Hospital Italiano de Buenos Aires; Argentina
Fil: Saez, M. S.. Hospital Italiano de Buenos Aires; Argentina
Fil: Ginaca, A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina
Fil: Mendez, Carlos Fernando. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina - Materia
-
Acute Renal Injury
Alternative Pathway
Complement
Hus - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/15194
Ver los metadatos del registro completo
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Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndromeFerraris, J. R.Ferraris, V.Acquier, Andrea BeatrizSorroche, P. B.Saez, M. S.Ginaca, A.Mendez, Carlos FernandoAcute Renal InjuryAlternative PathwayComplementHushttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome.Fil: Ferraris, J. R.. Hospital Italiano de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Ferraris, V.. Hospital Italiano de Buenos Aires; ArgentinaFil: Acquier, Andrea Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; ArgentinaFil: Sorroche, P. B.. Hospital Italiano de Buenos Aires; ArgentinaFil: Saez, M. S.. Hospital Italiano de Buenos Aires; ArgentinaFil: Ginaca, A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; ArgentinaFil: Mendez, Carlos Fernando. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; ArgentinaWiley2015-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15194Ferraris, J. R.; Ferraris, V.; Acquier, Andrea Beatriz; Sorroche, P. B.; Saez, M. S.; et al.; Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome; Wiley; Clinical and Experimental Immunology; 181; 1; 6-2015; 118-1250009-91041365-2249enginfo:eu-repo/semantics/altIdentifier/doi/10.1111/cei.12601info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/cei.12601/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:43Zoai:ri.conicet.gov.ar:11336/15194instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:43.654CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome |
title |
Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome |
spellingShingle |
Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome Ferraris, J. R. Acute Renal Injury Alternative Pathway Complement Hus |
title_short |
Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome |
title_full |
Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome |
title_fullStr |
Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome |
title_full_unstemmed |
Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome |
title_sort |
Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome |
dc.creator.none.fl_str_mv |
Ferraris, J. R. Ferraris, V. Acquier, Andrea Beatriz Sorroche, P. B. Saez, M. S. Ginaca, A. Mendez, Carlos Fernando |
author |
Ferraris, J. R. |
author_facet |
Ferraris, J. R. Ferraris, V. Acquier, Andrea Beatriz Sorroche, P. B. Saez, M. S. Ginaca, A. Mendez, Carlos Fernando |
author_role |
author |
author2 |
Ferraris, V. Acquier, Andrea Beatriz Sorroche, P. B. Saez, M. S. Ginaca, A. Mendez, Carlos Fernando |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Acute Renal Injury Alternative Pathway Complement Hus |
topic |
Acute Renal Injury Alternative Pathway Complement Hus |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.2 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome. Fil: Ferraris, J. R.. Hospital Italiano de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Ferraris, V.. Hospital Italiano de Buenos Aires; Argentina Fil: Acquier, Andrea Beatriz. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina Fil: Sorroche, P. B.. Hospital Italiano de Buenos Aires; Argentina Fil: Saez, M. S.. Hospital Italiano de Buenos Aires; Argentina Fil: Ginaca, A.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutierrez"; Argentina Fil: Mendez, Carlos Fernando. Universidad de Buenos Aires. Facultad de Odontología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina; Argentina |
description |
Haemolytic uraemic syndrome (HUS) is characterized by haemolytic anaemia, thrombocytopenia and acute renal failure. We studied the activation state of classical and alternative pathways of complement during the acute phase of Shiga toxin-associated HUS by performing a prospective study of 18 patients and 17 age-matched healthy controls to evaluate C3, C3c, C4, C4d, Bb and SC5b-9 levels. SC5b-9 levels were increased significantly in all patients at admission compared to healthy and end-stage renal disease controls, but were significantly higher in patients presenting with oliguria compared to those with preserved diuresis. C3 and C4 levels were elevated significantly at admission in the non-oliguric group when compared to controls. No significant differences were found for C4d values, whereas factor Bb was elevated in all patients and significantly higher in oliguric patients when compared to both controls and non-oliguric individuals. A positive and significant association was detected when Bb formation was plotted as a function of plasma SC5b-9 at admission. Bb levels declined rapidly during the first week, with values not significantly different from controls by days 3 and 5 for non-oligurics and oligurics, respectively. Our data demonstrate the activation of the alternative pathway of complement during the acute phase of Stx-associated HUS. This finding suggests that complement activation may represent an important trigger for the cell damage that occurs during the syndrome. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/15194 Ferraris, J. R.; Ferraris, V.; Acquier, Andrea Beatriz; Sorroche, P. B.; Saez, M. S.; et al.; Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome; Wiley; Clinical and Experimental Immunology; 181; 1; 6-2015; 118-125 0009-9104 1365-2249 |
url |
http://hdl.handle.net/11336/15194 |
identifier_str_mv |
Ferraris, J. R.; Ferraris, V.; Acquier, Andrea Beatriz; Sorroche, P. B.; Saez, M. S.; et al.; Activation of the alternative pathway of complement during the acute phase of typical haemolytic uraemic syndrome; Wiley; Clinical and Experimental Immunology; 181; 1; 6-2015; 118-125 0009-9104 1365-2249 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1111/cei.12601 info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/cei.12601/abstract |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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