Sodium iodide symporter-targeted gene therapy in glioblastoma

Autores
Nicola, Juan Pablo; LaRocca, Christopher J.
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sodium iodide symporter (NIS) gene transfer for active accumulation of radioactive iodide (or alternative radionuclides) in tumor cells is a powerful theranostic strategy allowing for both diagnostic and therapeutic applications. In the current issue of Molecular Therapy – Oncolytics, Spellerberg et al.1 designed NIS plasmid DNA polyplexes containing targeting ligands for the transferrin receptor (TfR) and the epidermal growth factor receptor (EGFR) in order to improve active transport across the blood-brain barrier, followed by targeting of glioblastoma cancer cells, an aggressive and therapeutically challenging brain tumor.
Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: LaRocca, Christopher J.. University of Minnesota; Estados Unidos
Materia
SODIUM IODIDE SYMPORTER
GENE THERAPHY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/255591
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/255591
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sodium iodide symporter-targeted gene therapy in glioblastomaNicola, Juan PabloLaRocca, Christopher J.SODIUM IODIDE SYMPORTERGENE THERAPHYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Sodium iodide symporter (NIS) gene transfer for active accumulation of radioactive iodide (or alternative radionuclides) in tumor cells is a powerful theranostic strategy allowing for both diagnostic and therapeutic applications. In the current issue of Molecular Therapy – Oncolytics, Spellerberg et al.1 designed NIS plasmid DNA polyplexes containing targeting ligands for the transferrin receptor (TfR) and the epidermal growth factor receptor (EGFR) in order to improve active transport across the blood-brain barrier, followed by targeting of glioblastoma cancer cells, an aggressive and therapeutically challenging brain tumor.Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: LaRocca, Christopher J.. University of Minnesota; Estados UnidosCell Press2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/255591Nicola, Juan Pablo; LaRocca, Christopher J.; Sodium iodide symporter-targeted gene therapy in glioblastoma; Cell Press; Molecular Therapy - Oncolytics; 28; 1-2023; 44-452372-7705CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2372770522001528info:eu-repo/semantics/altIdentifier/doi/10.1016/j.omto.2022.12.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:45:41Zoai:ri.conicet.gov.ar:11336/255591instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:45:41.318CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sodium iodide symporter-targeted gene therapy in glioblastoma
title Sodium iodide symporter-targeted gene therapy in glioblastoma
spellingShingle Sodium iodide symporter-targeted gene therapy in glioblastoma
Nicola, Juan Pablo
SODIUM IODIDE SYMPORTER
GENE THERAPHY
title_short Sodium iodide symporter-targeted gene therapy in glioblastoma
title_full Sodium iodide symporter-targeted gene therapy in glioblastoma
title_fullStr Sodium iodide symporter-targeted gene therapy in glioblastoma
title_full_unstemmed Sodium iodide symporter-targeted gene therapy in glioblastoma
title_sort Sodium iodide symporter-targeted gene therapy in glioblastoma
dc.creator.none.fl_str_mv Nicola, Juan Pablo
LaRocca, Christopher J.
author Nicola, Juan Pablo
author_facet Nicola, Juan Pablo
LaRocca, Christopher J.
author_role author
author2 LaRocca, Christopher J.
author2_role author
dc.subject.none.fl_str_mv SODIUM IODIDE SYMPORTER
GENE THERAPHY
topic SODIUM IODIDE SYMPORTER
GENE THERAPHY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Sodium iodide symporter (NIS) gene transfer for active accumulation of radioactive iodide (or alternative radionuclides) in tumor cells is a powerful theranostic strategy allowing for both diagnostic and therapeutic applications. In the current issue of Molecular Therapy – Oncolytics, Spellerberg et al.1 designed NIS plasmid DNA polyplexes containing targeting ligands for the transferrin receptor (TfR) and the epidermal growth factor receptor (EGFR) in order to improve active transport across the blood-brain barrier, followed by targeting of glioblastoma cancer cells, an aggressive and therapeutically challenging brain tumor.
Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: LaRocca, Christopher J.. University of Minnesota; Estados Unidos
description Sodium iodide symporter (NIS) gene transfer for active accumulation of radioactive iodide (or alternative radionuclides) in tumor cells is a powerful theranostic strategy allowing for both diagnostic and therapeutic applications. In the current issue of Molecular Therapy – Oncolytics, Spellerberg et al.1 designed NIS plasmid DNA polyplexes containing targeting ligands for the transferrin receptor (TfR) and the epidermal growth factor receptor (EGFR) in order to improve active transport across the blood-brain barrier, followed by targeting of glioblastoma cancer cells, an aggressive and therapeutically challenging brain tumor.
publishDate 2023
dc.date.none.fl_str_mv 2023-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/255591
Nicola, Juan Pablo; LaRocca, Christopher J.; Sodium iodide symporter-targeted gene therapy in glioblastoma; Cell Press; Molecular Therapy - Oncolytics; 28; 1-2023; 44-45
2372-7705
CONICET Digital
CONICET
url http://hdl.handle.net/11336/255591
identifier_str_mv Nicola, Juan Pablo; LaRocca, Christopher J.; Sodium iodide symporter-targeted gene therapy in glioblastoma; Cell Press; Molecular Therapy - Oncolytics; 28; 1-2023; 44-45
2372-7705
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2372770522001528
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.omto.2022.12.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083556079566848
score 13.22299

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