Sodium iodide symporter-targeted gene therapy in glioblastoma
- Autores
- Nicola, Juan Pablo; LaRocca, Christopher J.
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Sodium iodide symporter (NIS) gene transfer for active accumulation of radioactive iodide (or alternative radionuclides) in tumor cells is a powerful theranostic strategy allowing for both diagnostic and therapeutic applications. In the current issue of Molecular Therapy – Oncolytics, Spellerberg et al.1 designed NIS plasmid DNA polyplexes containing targeting ligands for the transferrin receptor (TfR) and the epidermal growth factor receptor (EGFR) in order to improve active transport across the blood-brain barrier, followed by targeting of glioblastoma cancer cells, an aggressive and therapeutically challenging brain tumor.
Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: LaRocca, Christopher J.. University of Minnesota; Estados Unidos - Materia
-
SODIUM IODIDE SYMPORTER
GENE THERAPHY - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/255591
Ver los metadatos del registro completo
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Sodium iodide symporter-targeted gene therapy in glioblastomaNicola, Juan PabloLaRocca, Christopher J.SODIUM IODIDE SYMPORTERGENE THERAPHYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Sodium iodide symporter (NIS) gene transfer for active accumulation of radioactive iodide (or alternative radionuclides) in tumor cells is a powerful theranostic strategy allowing for both diagnostic and therapeutic applications. In the current issue of Molecular Therapy – Oncolytics, Spellerberg et al.1 designed NIS plasmid DNA polyplexes containing targeting ligands for the transferrin receptor (TfR) and the epidermal growth factor receptor (EGFR) in order to improve active transport across the blood-brain barrier, followed by targeting of glioblastoma cancer cells, an aggressive and therapeutically challenging brain tumor.Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: LaRocca, Christopher J.. University of Minnesota; Estados UnidosCell Press2023-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/255591Nicola, Juan Pablo; LaRocca, Christopher J.; Sodium iodide symporter-targeted gene therapy in glioblastoma; Cell Press; Molecular Therapy - Oncolytics; 28; 1-2023; 44-452372-7705CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2372770522001528info:eu-repo/semantics/altIdentifier/doi/10.1016/j.omto.2022.12.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:47:04Zoai:ri.conicet.gov.ar:11336/255591instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:47:04.287CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Sodium iodide symporter-targeted gene therapy in glioblastoma |
title |
Sodium iodide symporter-targeted gene therapy in glioblastoma |
spellingShingle |
Sodium iodide symporter-targeted gene therapy in glioblastoma Nicola, Juan Pablo SODIUM IODIDE SYMPORTER GENE THERAPHY |
title_short |
Sodium iodide symporter-targeted gene therapy in glioblastoma |
title_full |
Sodium iodide symporter-targeted gene therapy in glioblastoma |
title_fullStr |
Sodium iodide symporter-targeted gene therapy in glioblastoma |
title_full_unstemmed |
Sodium iodide symporter-targeted gene therapy in glioblastoma |
title_sort |
Sodium iodide symporter-targeted gene therapy in glioblastoma |
dc.creator.none.fl_str_mv |
Nicola, Juan Pablo LaRocca, Christopher J. |
author |
Nicola, Juan Pablo |
author_facet |
Nicola, Juan Pablo LaRocca, Christopher J. |
author_role |
author |
author2 |
LaRocca, Christopher J. |
author2_role |
author |
dc.subject.none.fl_str_mv |
SODIUM IODIDE SYMPORTER GENE THERAPHY |
topic |
SODIUM IODIDE SYMPORTER GENE THERAPHY |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Sodium iodide symporter (NIS) gene transfer for active accumulation of radioactive iodide (or alternative radionuclides) in tumor cells is a powerful theranostic strategy allowing for both diagnostic and therapeutic applications. In the current issue of Molecular Therapy – Oncolytics, Spellerberg et al.1 designed NIS plasmid DNA polyplexes containing targeting ligands for the transferrin receptor (TfR) and the epidermal growth factor receptor (EGFR) in order to improve active transport across the blood-brain barrier, followed by targeting of glioblastoma cancer cells, an aggressive and therapeutically challenging brain tumor. Fil: Nicola, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina Fil: LaRocca, Christopher J.. University of Minnesota; Estados Unidos |
description |
Sodium iodide symporter (NIS) gene transfer for active accumulation of radioactive iodide (or alternative radionuclides) in tumor cells is a powerful theranostic strategy allowing for both diagnostic and therapeutic applications. In the current issue of Molecular Therapy – Oncolytics, Spellerberg et al.1 designed NIS plasmid DNA polyplexes containing targeting ligands for the transferrin receptor (TfR) and the epidermal growth factor receptor (EGFR) in order to improve active transport across the blood-brain barrier, followed by targeting of glioblastoma cancer cells, an aggressive and therapeutically challenging brain tumor. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/255591 Nicola, Juan Pablo; LaRocca, Christopher J.; Sodium iodide symporter-targeted gene therapy in glioblastoma; Cell Press; Molecular Therapy - Oncolytics; 28; 1-2023; 44-45 2372-7705 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/255591 |
identifier_str_mv |
Nicola, Juan Pablo; LaRocca, Christopher J.; Sodium iodide symporter-targeted gene therapy in glioblastoma; Cell Press; Molecular Therapy - Oncolytics; 28; 1-2023; 44-45 2372-7705 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2372770522001528 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.omto.2022.12.004 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Cell Press |
publisher.none.fl_str_mv |
Cell Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614513416994816 |
score |
13.070432 |