Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation
- Autores
- Yushchenko, Dmytro A.; Fauerbach, Jonathan Arturo; Thirunavukkuarasu, Shyamala; Jares, Elizabeth Andrea; Jovin, Thomas M.
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of α-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of α-synuclein aggregation, a process associated with Parkinsons disease.
Fil: Yushchenko, Dmytro A.. Max Planck Institute for Biophysical Chemistry; Alemania
Fil: Fauerbach, Jonathan Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina
Fil: Thirunavukkuarasu, Shyamala. Max Planck Institute for Biophysical Chemistry; Alemania
Fil: Jares, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina
Fil: Jovin, Thomas M.. Max Planck Institute for Biophysical Chemistry; Alemania - Materia
-
Polarity Sensitive Dyes
Amyloid
Synuclein - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/68821
Ver los metadatos del registro completo
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Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregationYushchenko, Dmytro A.Fauerbach, Jonathan ArturoThirunavukkuarasu, ShyamalaJares, Elizabeth AndreaJovin, Thomas M.Polarity Sensitive DyesAmyloidSynucleinhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of α-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of α-synuclein aggregation, a process associated with Parkinsons disease.Fil: Yushchenko, Dmytro A.. Max Planck Institute for Biophysical Chemistry; AlemaniaFil: Fauerbach, Jonathan Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Thirunavukkuarasu, Shyamala. Max Planck Institute for Biophysical Chemistry; AlemaniaFil: Jares, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; ArgentinaFil: Jovin, Thomas M.. Max Planck Institute for Biophysical Chemistry; AlemaniaAmerican Chemical Society2010-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/68821Yushchenko, Dmytro A.; Fauerbach, Jonathan Arturo; Thirunavukkuarasu, Shyamala; Jares, Elizabeth Andrea; Jovin, Thomas M.; Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation; American Chemical Society; Journal of the American Chemical Society; 132; 23; 6-2010; 7860-78610002-7863CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/ja102838ninfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/ja102838ninfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:20Zoai:ri.conicet.gov.ar:11336/68821instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:20.671CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation |
title |
Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation |
spellingShingle |
Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation Yushchenko, Dmytro A. Polarity Sensitive Dyes Amyloid Synuclein |
title_short |
Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation |
title_full |
Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation |
title_fullStr |
Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation |
title_full_unstemmed |
Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation |
title_sort |
Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation |
dc.creator.none.fl_str_mv |
Yushchenko, Dmytro A. Fauerbach, Jonathan Arturo Thirunavukkuarasu, Shyamala Jares, Elizabeth Andrea Jovin, Thomas M. |
author |
Yushchenko, Dmytro A. |
author_facet |
Yushchenko, Dmytro A. Fauerbach, Jonathan Arturo Thirunavukkuarasu, Shyamala Jares, Elizabeth Andrea Jovin, Thomas M. |
author_role |
author |
author2 |
Fauerbach, Jonathan Arturo Thirunavukkuarasu, Shyamala Jares, Elizabeth Andrea Jovin, Thomas M. |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
Polarity Sensitive Dyes Amyloid Synuclein |
topic |
Polarity Sensitive Dyes Amyloid Synuclein |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of α-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of α-synuclein aggregation, a process associated with Parkinsons disease. Fil: Yushchenko, Dmytro A.. Max Planck Institute for Biophysical Chemistry; Alemania Fil: Fauerbach, Jonathan Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina Fil: Thirunavukkuarasu, Shyamala. Max Planck Institute for Biophysical Chemistry; Alemania Fil: Jares, Elizabeth Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Centro de Investigaciones en Hidratos de Carbono; Argentina Fil: Jovin, Thomas M.. Max Planck Institute for Biophysical Chemistry; Alemania |
description |
We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of α-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of α-synuclein aggregation, a process associated with Parkinsons disease. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/68821 Yushchenko, Dmytro A.; Fauerbach, Jonathan Arturo; Thirunavukkuarasu, Shyamala; Jares, Elizabeth Andrea; Jovin, Thomas M.; Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation; American Chemical Society; Journal of the American Chemical Society; 132; 23; 6-2010; 7860-7861 0002-7863 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/68821 |
identifier_str_mv |
Yushchenko, Dmytro A.; Fauerbach, Jonathan Arturo; Thirunavukkuarasu, Shyamala; Jares, Elizabeth Andrea; Jovin, Thomas M.; Fluorescent ratiometric MFC probe sensitive to early stages of α-Synuclein aggregation; American Chemical Society; Journal of the American Chemical Society; 132; 23; 6-2010; 7860-7861 0002-7863 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1021/ja102838n info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/abs/10.1021/ja102838n |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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score |
13.13397 |