Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance

Autores
Nardy, Ana F. F. R.; Freire de Lima, Celio G.; Perez, Ana Rosa; Morrot, Alexandre
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundamental role in such immunopathological events. This unusual enzyme catalyses the transference of sialic acid molecules from host glycoconjugates to acceptor molecules placed on the parasite surface. TS activity mediates several biological effects leading to the subversion of host immune system, hence favoring both parasite survival and the establishment of chronic infection. This review summarizes current findings on the roles of TS in the immune response during T. cruzi infection.
Fil: Nardy, Ana F. F. R.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Freire de Lima, Celio G.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Morrot, Alexandre. Universidade Federal do Rio de Janeiro; Brasil
Materia
GLYCOIMMUNOLOGY
IMMUNE EVASION
PARASITES
TRANS-SIALIDASE
TRYPANOSOMA CRUZI
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/53304
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillanceNardy, Ana F. F. R.Freire de Lima, Celio G.Perez, Ana RosaMorrot, AlexandreGLYCOIMMUNOLOGYIMMUNE EVASIONPARASITESTRANS-SIALIDASETRYPANOSOMA CRUZIhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundamental role in such immunopathological events. This unusual enzyme catalyses the transference of sialic acid molecules from host glycoconjugates to acceptor molecules placed on the parasite surface. TS activity mediates several biological effects leading to the subversion of host immune system, hence favoring both parasite survival and the establishment of chronic infection. This review summarizes current findings on the roles of TS in the immune response during T. cruzi infection.Fil: Nardy, Ana F. F. R.. Universidade Federal do Rio de Janeiro; BrasilFil: Freire de Lima, Celio G.. Universidade Federal do Rio de Janeiro; BrasilFil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Morrot, Alexandre. Universidade Federal do Rio de Janeiro; BrasilFrontiers Media S.A.2016-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/53304Nardy, Ana F. F. R.; Freire de Lima, Celio G.; Perez, Ana Rosa; Morrot, Alexandre; Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance; Frontiers Media S.A.; Frontiers in Microbiology; 7; MAR; 3-2016; 1-91664-302XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmicb.2016.00348info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmicb.2016.00348/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:11:04Zoai:ri.conicet.gov.ar:11336/53304instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:11:04.998CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
title Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
spellingShingle Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
Nardy, Ana F. F. R.
GLYCOIMMUNOLOGY
IMMUNE EVASION
PARASITES
TRANS-SIALIDASE
TRYPANOSOMA CRUZI
title_short Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
title_full Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
title_fullStr Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
title_full_unstemmed Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
title_sort Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance
dc.creator.none.fl_str_mv Nardy, Ana F. F. R.
Freire de Lima, Celio G.
Perez, Ana Rosa
Morrot, Alexandre
author Nardy, Ana F. F. R.
author_facet Nardy, Ana F. F. R.
Freire de Lima, Celio G.
Perez, Ana Rosa
Morrot, Alexandre
author_role author
author2 Freire de Lima, Celio G.
Perez, Ana Rosa
Morrot, Alexandre
author2_role author
author
author
dc.subject.none.fl_str_mv GLYCOIMMUNOLOGY
IMMUNE EVASION
PARASITES
TRANS-SIALIDASE
TRYPANOSOMA CRUZI
topic GLYCOIMMUNOLOGY
IMMUNE EVASION
PARASITES
TRANS-SIALIDASE
TRYPANOSOMA CRUZI
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundamental role in such immunopathological events. This unusual enzyme catalyses the transference of sialic acid molecules from host glycoconjugates to acceptor molecules placed on the parasite surface. TS activity mediates several biological effects leading to the subversion of host immune system, hence favoring both parasite survival and the establishment of chronic infection. This review summarizes current findings on the roles of TS in the immune response during T. cruzi infection.
Fil: Nardy, Ana F. F. R.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Freire de Lima, Celio G.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentina
Fil: Morrot, Alexandre. Universidade Federal do Rio de Janeiro; Brasil
description Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundamental role in such immunopathological events. This unusual enzyme catalyses the transference of sialic acid molecules from host glycoconjugates to acceptor molecules placed on the parasite surface. TS activity mediates several biological effects leading to the subversion of host immune system, hence favoring both parasite survival and the establishment of chronic infection. This review summarizes current findings on the roles of TS in the immune response during T. cruzi infection.
publishDate 2016
dc.date.none.fl_str_mv 2016-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/53304
Nardy, Ana F. F. R.; Freire de Lima, Celio G.; Perez, Ana Rosa; Morrot, Alexandre; Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance; Frontiers Media S.A.; Frontiers in Microbiology; 7; MAR; 3-2016; 1-9
1664-302X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/53304
identifier_str_mv Nardy, Ana F. F. R.; Freire de Lima, Celio G.; Perez, Ana Rosa; Morrot, Alexandre; Role of Trypanosoma cruzi Trans-sialidase on the escape from host immune surveillance; Frontiers Media S.A.; Frontiers in Microbiology; 7; MAR; 3-2016; 1-9
1664-302X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fmicb.2016.00348
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmicb.2016.00348/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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