El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana

Autores
Vanagas, Laura; Rossi, Juan Pablo Francisco
Año de publicación
2008
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The cytoskeleton is a network of proteic filaments which occupy the interior of all vegetable and animal cells. It has a special relevance in the latter, which lack a rigid cellular wall, because it maintains the structure and shape of the cell. It acts as a support for the organization and fixation of organelles and enzymes. In many cells, the cytoskeleton is not a permanent structure, but instead it is continuously being dismantled and reconstructed. It is formed by three main types of proteic filaments: microtubules, actin filaments and intermediate filaments, bound together and to other cellular structures. The controlled polymerization of actin and tubulin is responsible for both the mobility and shape of eukaryotic cells. The movement of eukaryotic cells is the result of the coordinated action of the formation of extensions, adhesions and retractions of the membrane, where the actin network and the interactions between these and molecular motors play a key role. The microtubules control the spatial distribution of these activities, creating a polarization of the cell which determines the direction of movement. Recent studies of our laboratory (Vanagas and col, 2007, 2008) show that monomeric actin activates calcium transport in the membrane of red blood cells, whereas polymeric or filamentous actin inhibits it. This phenomenon seems to be a general property of all membrane proteins in which the cytoskeleton is no longer restricted to a merely mechanical function, but rather would produce the modulation of the activity of the integral proteins to which it is related to.
Fil: Vanagas, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Rossi, Juan Pablo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Materia
cytoskeleton
membrane proteins
plasma membrane calcium pump
ATPases
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/174328
Acceder
id CONICETDig_8e0caf55cb33191d7aa8f0d3db077a0d
oai_identifier_str oai:ri.conicet.gov.ar:11336/174328
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling El citoesquleto: Funciones estructurales y de regulación de las proteinas de membranaThe cytoskeleton: Structural function and regulation of membrane proteinsVanagas, LauraRossi, Juan Pablo Franciscocytoskeletonmembrane proteinsplasma membrane calcium pumpATPaseshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The cytoskeleton is a network of proteic filaments which occupy the interior of all vegetable and animal cells. It has a special relevance in the latter, which lack a rigid cellular wall, because it maintains the structure and shape of the cell. It acts as a support for the organization and fixation of organelles and enzymes. In many cells, the cytoskeleton is not a permanent structure, but instead it is continuously being dismantled and reconstructed. It is formed by three main types of proteic filaments: microtubules, actin filaments and intermediate filaments, bound together and to other cellular structures. The controlled polymerization of actin and tubulin is responsible for both the mobility and shape of eukaryotic cells. The movement of eukaryotic cells is the result of the coordinated action of the formation of extensions, adhesions and retractions of the membrane, where the actin network and the interactions between these and molecular motors play a key role. The microtubules control the spatial distribution of these activities, creating a polarization of the cell which determines the direction of movement. Recent studies of our laboratory (Vanagas and col, 2007, 2008) show that monomeric actin activates calcium transport in the membrane of red blood cells, whereas polymeric or filamentous actin inhibits it. This phenomenon seems to be a general property of all membrane proteins in which the cytoskeleton is no longer restricted to a merely mechanical function, but rather would produce the modulation of the activity of the integral proteins to which it is related to.Fil: Vanagas, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaFil: Rossi, Juan Pablo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; ArgentinaAcademia Nacional de Farmacia y Bioquímica2008-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/174328Vanagas, Laura; Rossi, Juan Pablo Francisco; El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana; Academia Nacional de Farmacia y Bioquímica; Revista Farmacéutica; 150; 1; 7-2008; 26-370034-9496CONICET DigitalCONICETspainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:44:36Zoai:ri.conicet.gov.ar:11336/174328instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:44:36.628CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana
The cytoskeleton: Structural function and regulation of membrane proteins
title El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana
spellingShingle El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana
Vanagas, Laura
cytoskeleton
membrane proteins
plasma membrane calcium pump
ATPases
title_short El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana
title_full El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana
title_fullStr El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana
title_full_unstemmed El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana
title_sort El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana
dc.creator.none.fl_str_mv Vanagas, Laura
Rossi, Juan Pablo Francisco
author Vanagas, Laura
author_facet Vanagas, Laura
Rossi, Juan Pablo Francisco
author_role author
author2 Rossi, Juan Pablo Francisco
author2_role author
dc.subject.none.fl_str_mv cytoskeleton
membrane proteins
plasma membrane calcium pump
ATPases
topic cytoskeleton
membrane proteins
plasma membrane calcium pump
ATPases
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The cytoskeleton is a network of proteic filaments which occupy the interior of all vegetable and animal cells. It has a special relevance in the latter, which lack a rigid cellular wall, because it maintains the structure and shape of the cell. It acts as a support for the organization and fixation of organelles and enzymes. In many cells, the cytoskeleton is not a permanent structure, but instead it is continuously being dismantled and reconstructed. It is formed by three main types of proteic filaments: microtubules, actin filaments and intermediate filaments, bound together and to other cellular structures. The controlled polymerization of actin and tubulin is responsible for both the mobility and shape of eukaryotic cells. The movement of eukaryotic cells is the result of the coordinated action of the formation of extensions, adhesions and retractions of the membrane, where the actin network and the interactions between these and molecular motors play a key role. The microtubules control the spatial distribution of these activities, creating a polarization of the cell which determines the direction of movement. Recent studies of our laboratory (Vanagas and col, 2007, 2008) show that monomeric actin activates calcium transport in the membrane of red blood cells, whereas polymeric or filamentous actin inhibits it. This phenomenon seems to be a general property of all membrane proteins in which the cytoskeleton is no longer restricted to a merely mechanical function, but rather would produce the modulation of the activity of the integral proteins to which it is related to.
Fil: Vanagas, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
Fil: Rossi, Juan Pablo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Físico-Química Biológicas "Prof. Alejandro C. Paladini". Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Físico-Química Biológicas; Argentina
description The cytoskeleton is a network of proteic filaments which occupy the interior of all vegetable and animal cells. It has a special relevance in the latter, which lack a rigid cellular wall, because it maintains the structure and shape of the cell. It acts as a support for the organization and fixation of organelles and enzymes. In many cells, the cytoskeleton is not a permanent structure, but instead it is continuously being dismantled and reconstructed. It is formed by three main types of proteic filaments: microtubules, actin filaments and intermediate filaments, bound together and to other cellular structures. The controlled polymerization of actin and tubulin is responsible for both the mobility and shape of eukaryotic cells. The movement of eukaryotic cells is the result of the coordinated action of the formation of extensions, adhesions and retractions of the membrane, where the actin network and the interactions between these and molecular motors play a key role. The microtubules control the spatial distribution of these activities, creating a polarization of the cell which determines the direction of movement. Recent studies of our laboratory (Vanagas and col, 2007, 2008) show that monomeric actin activates calcium transport in the membrane of red blood cells, whereas polymeric or filamentous actin inhibits it. This phenomenon seems to be a general property of all membrane proteins in which the cytoskeleton is no longer restricted to a merely mechanical function, but rather would produce the modulation of the activity of the integral proteins to which it is related to.
publishDate 2008
dc.date.none.fl_str_mv 2008-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/174328
Vanagas, Laura; Rossi, Juan Pablo Francisco; El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana; Academia Nacional de Farmacia y Bioquímica; Revista Farmacéutica; 150; 1; 7-2008; 26-37
0034-9496
CONICET Digital
CONICET
url http://hdl.handle.net/11336/174328
identifier_str_mv Vanagas, Laura; Rossi, Juan Pablo Francisco; El citoesquleto: Funciones estructurales y de regulación de las proteinas de membrana; Academia Nacional de Farmacia y Bioquímica; Revista Farmacéutica; 150; 1; 7-2008; 26-37
0034-9496
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academia Nacional de Farmacia y Bioquímica
publisher.none.fl_str_mv Academia Nacional de Farmacia y Bioquímica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614484019118080
score 13.070432

Publicaciones similares