High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
- Autores
- Oliveira Meneses, Marcela; Dariva, Claudio; Rodrigues Borges, Gustavo; da Rocha, Sandro R. P.; Zabaloy, Marcelo Santiago; Franceschi, Elton
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The development of polymeric systems for drug deliveryhas received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000and 2000 g·mol−1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid−liquid equilibrium,liquid−liquid−vapor equilibrium, and, in some cases, solid−liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer.
Fil: Oliveira Meneses, Marcela. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Fil: Dariva, Claudio. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Fil: Rodrigues Borges, Gustavo. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Fil: da Rocha, Sandro R. P.. Virginia Commonwealth University; Estados Unidos
Fil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Franceschi, Elton. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil - Materia
-
Polyethylene Glycol
Tetrafluoroethane
Phase Behavior
High Pressure - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/30024
Ver los metadatos del registro completo
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High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane SystemsOliveira Meneses, MarcelaDariva, ClaudioRodrigues Borges, Gustavoda Rocha, Sandro R. P.Zabaloy, Marcelo SantiagoFranceschi, EltonPolyethylene GlycolTetrafluoroethanePhase BehaviorHigh Pressurehttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2The development of polymeric systems for drug deliveryhas received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000and 2000 g·mol−1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid−liquid equilibrium,liquid−liquid−vapor equilibrium, and, in some cases, solid−liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer.Fil: Oliveira Meneses, Marcela. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; BrasilFil: Dariva, Claudio. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; BrasilFil: Rodrigues Borges, Gustavo. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; BrasilFil: da Rocha, Sandro R. P.. Virginia Commonwealth University; Estados UnidosFil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Franceschi, Elton. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; BrasilAmerican Chemical Society2017-05-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30024Oliveira Meneses, Marcela; Dariva, Claudio; Rodrigues Borges, Gustavo; da Rocha, Sandro R. P.; Zabaloy, Marcelo Santiago; et al.; High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems; American Chemical Society; Journal of Chemical and Engineering Data; 62; 6; 4-5-2017; 1853-18580021-9568CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/acs.jced.7b00180info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jced.7b00180info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:57:27Zoai:ri.conicet.gov.ar:11336/30024instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:57:27.74CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems |
title |
High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems |
spellingShingle |
High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems Oliveira Meneses, Marcela Polyethylene Glycol Tetrafluoroethane Phase Behavior High Pressure |
title_short |
High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems |
title_full |
High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems |
title_fullStr |
High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems |
title_full_unstemmed |
High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems |
title_sort |
High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems |
dc.creator.none.fl_str_mv |
Oliveira Meneses, Marcela Dariva, Claudio Rodrigues Borges, Gustavo da Rocha, Sandro R. P. Zabaloy, Marcelo Santiago Franceschi, Elton |
author |
Oliveira Meneses, Marcela |
author_facet |
Oliveira Meneses, Marcela Dariva, Claudio Rodrigues Borges, Gustavo da Rocha, Sandro R. P. Zabaloy, Marcelo Santiago Franceschi, Elton |
author_role |
author |
author2 |
Dariva, Claudio Rodrigues Borges, Gustavo da Rocha, Sandro R. P. Zabaloy, Marcelo Santiago Franceschi, Elton |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Polyethylene Glycol Tetrafluoroethane Phase Behavior High Pressure |
topic |
Polyethylene Glycol Tetrafluoroethane Phase Behavior High Pressure |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/2.4 https://purl.org/becyt/ford/2 |
dc.description.none.fl_txt_mv |
The development of polymeric systems for drug deliveryhas received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000and 2000 g·mol−1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid−liquid equilibrium,liquid−liquid−vapor equilibrium, and, in some cases, solid−liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer. Fil: Oliveira Meneses, Marcela. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil Fil: Dariva, Claudio. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil Fil: Rodrigues Borges, Gustavo. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil Fil: da Rocha, Sandro R. P.. Virginia Commonwealth University; Estados Unidos Fil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina Fil: Franceschi, Elton. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil |
description |
The development of polymeric systems for drug deliveryhas received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000and 2000 g·mol−1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid−liquid equilibrium,liquid−liquid−vapor equilibrium, and, in some cases, solid−liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-05-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/30024 Oliveira Meneses, Marcela; Dariva, Claudio; Rodrigues Borges, Gustavo; da Rocha, Sandro R. P.; Zabaloy, Marcelo Santiago; et al.; High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems; American Chemical Society; Journal of Chemical and Engineering Data; 62; 6; 4-5-2017; 1853-1858 0021-9568 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/30024 |
identifier_str_mv |
Oliveira Meneses, Marcela; Dariva, Claudio; Rodrigues Borges, Gustavo; da Rocha, Sandro R. P.; Zabaloy, Marcelo Santiago; et al.; High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems; American Chemical Society; Journal of Chemical and Engineering Data; 62; 6; 4-5-2017; 1853-1858 0021-9568 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/acs.jced.7b00180 info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jced.7b00180 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Chemical Society |
publisher.none.fl_str_mv |
American Chemical Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613718665592832 |
score |
13.070432 |