High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems

Autores
Oliveira Meneses, Marcela; Dariva, Claudio; Rodrigues Borges, Gustavo; da Rocha, Sandro R. P.; Zabaloy, Marcelo Santiago; Franceschi, Elton
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The development of polymeric systems for drug deliveryhas received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000and 2000 g·mol−1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid−liquid equilibrium,liquid−liquid−vapor equilibrium, and, in some cases, solid−liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer.
Fil: Oliveira Meneses, Marcela. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Fil: Dariva, Claudio. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Fil: Rodrigues Borges, Gustavo. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Fil: da Rocha, Sandro R. P.. Virginia Commonwealth University; Estados Unidos
Fil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Franceschi, Elton. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Materia
Polyethylene Glycol
Tetrafluoroethane
Phase Behavior
High Pressure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30024
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/30024
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane SystemsOliveira Meneses, MarcelaDariva, ClaudioRodrigues Borges, Gustavoda Rocha, Sandro R. P.Zabaloy, Marcelo SantiagoFranceschi, EltonPolyethylene GlycolTetrafluoroethanePhase BehaviorHigh Pressurehttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2The development of polymeric systems for drug deliveryhas received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000and 2000 g·mol−1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid−liquid equilibrium,liquid−liquid−vapor equilibrium, and, in some cases, solid−liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer.Fil: Oliveira Meneses, Marcela. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; BrasilFil: Dariva, Claudio. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; BrasilFil: Rodrigues Borges, Gustavo. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; BrasilFil: da Rocha, Sandro R. P.. Virginia Commonwealth University; Estados UnidosFil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Franceschi, Elton. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; BrasilAmerican Chemical Society2017-05-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30024Oliveira Meneses, Marcela; Dariva, Claudio; Rodrigues Borges, Gustavo; da Rocha, Sandro R. P.; Zabaloy, Marcelo Santiago; et al.; High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems; American Chemical Society; Journal of Chemical and Engineering Data; 62; 6; 4-5-2017; 1853-18580021-9568CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/acs.jced.7b00180info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jced.7b00180info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:26:43Zoai:ri.conicet.gov.ar:11336/30024instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:26:44.028CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
title High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
spellingShingle High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
Oliveira Meneses, Marcela
Polyethylene Glycol
Tetrafluoroethane
Phase Behavior
High Pressure
title_short High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
title_full High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
title_fullStr High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
title_full_unstemmed High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
title_sort High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems
dc.creator.none.fl_str_mv Oliveira Meneses, Marcela
Dariva, Claudio
Rodrigues Borges, Gustavo
da Rocha, Sandro R. P.
Zabaloy, Marcelo Santiago
Franceschi, Elton
author Oliveira Meneses, Marcela
author_facet Oliveira Meneses, Marcela
Dariva, Claudio
Rodrigues Borges, Gustavo
da Rocha, Sandro R. P.
Zabaloy, Marcelo Santiago
Franceschi, Elton
author_role author
author2 Dariva, Claudio
Rodrigues Borges, Gustavo
da Rocha, Sandro R. P.
Zabaloy, Marcelo Santiago
Franceschi, Elton
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Polyethylene Glycol
Tetrafluoroethane
Phase Behavior
High Pressure
topic Polyethylene Glycol
Tetrafluoroethane
Phase Behavior
High Pressure
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The development of polymeric systems for drug deliveryhas received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000and 2000 g·mol−1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid−liquid equilibrium,liquid−liquid−vapor equilibrium, and, in some cases, solid−liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer.
Fil: Oliveira Meneses, Marcela. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Fil: Dariva, Claudio. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Fil: Rodrigues Borges, Gustavo. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
Fil: da Rocha, Sandro R. P.. Virginia Commonwealth University; Estados Unidos
Fil: Zabaloy, Marcelo Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina
Fil: Franceschi, Elton. Universidade Tiradentes. Programa de Pós-Graduação em Engenharia de Processos. Instituto de Tecnologia e Pesquisa; Brasil
description The development of polymeric systems for drug deliveryhas received attention with the aim of producing new systems as an alternative to conventional drug therapy. The design of new systems for this purpose in a compressed medium requires a knowledge of the phase behavior for the polymeric matrix in the high-pressure fluids. This work reports the phase equilibrium experimental data of binary systems involving poly(ethylene glycol) (PEG) with molecular weights of 1000and 2000 g·mol−1 and 1,1,1,2-tetrafluoroethane (HFA-134a). The experimental data were obtained in a high-pressure variable-volume viewing cell based on the static synthetic method at temperatures from 287.4 to 334.2 K, pressures of up to 29.81 MPa, and a PEG concentration in the range of 1 to 7 wt %. Liquid−liquid equilibrium,liquid−liquid−vapor equilibrium, and, in some cases, solid−liquid equilibrium were observed under the experimental conditions of pressure, temperature, and compositions investigated. The experimental results show that temperature and pressure have significant influences on the solubility of PEG in HFA-134a. The solid-phase formation for the system PEG + HFA-134a, in the range of values investigated for temperature, pressure, and compositions, is influenced by the molecular weight of the polymer.
publishDate 2017
dc.date.none.fl_str_mv 2017-05-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30024
Oliveira Meneses, Marcela; Dariva, Claudio; Rodrigues Borges, Gustavo; da Rocha, Sandro R. P.; Zabaloy, Marcelo Santiago; et al.; High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems; American Chemical Society; Journal of Chemical and Engineering Data; 62; 6; 4-5-2017; 1853-1858
0021-9568
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30024
identifier_str_mv Oliveira Meneses, Marcela; Dariva, Claudio; Rodrigues Borges, Gustavo; da Rocha, Sandro R. P.; Zabaloy, Marcelo Santiago; et al.; High-Pressure Phase Behavior for Poly(ethylene glycol) and 1,1,1,2-Tetrafluorethane Systems; American Chemical Society; Journal of Chemical and Engineering Data; 62; 6; 4-5-2017; 1853-1858
0021-9568
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/acs.jced.7b00180
info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.jced.7b00180
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781828698996736
score 12.982451

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