Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter

Autores
Sieira, Rodrigo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Many intracellular bacterial pathogens use type IV secretion systems to deliver effector molecules and subvert the eukaryotic host cell defenses. The genus Brucella comprises facultative intracellular bacteria that cause brucellosis, a disease affecting a wide range of mammals including humans. The virB operon codes for a type IV secretion system that plays a central role in intracellular survival and replication of Brucella within the host. Expression of the virB genes is under the control of various transcription factors that allow this system to respond to different types of environmental signals, and display binding site structures and arrangements that define the intrinsic complexity of the virB promoter. This review focuses on summarizing the current state of research concerning regulation of the Brucella virB operon, with special emphasis on describing the nature and function of the implicated regulatory elements and examining the involved protein-DNA interactions.
Fil: Sieira, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Materia
Brucella
Type Iv Secretion System
Virb
Regulation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/18330
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoterSieira, RodrigoBrucellaType Iv Secretion SystemVirbRegulationhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Many intracellular bacterial pathogens use type IV secretion systems to deliver effector molecules and subvert the eukaryotic host cell defenses. The genus Brucella comprises facultative intracellular bacteria that cause brucellosis, a disease affecting a wide range of mammals including humans. The virB operon codes for a type IV secretion system that plays a central role in intracellular survival and replication of Brucella within the host. Expression of the virB genes is under the control of various transcription factors that allow this system to respond to different types of environmental signals, and display binding site structures and arrangements that define the intrinsic complexity of the virB promoter. This review focuses on summarizing the current state of research concerning regulation of the Brucella virB operon, with special emphasis on describing the nature and function of the implicated regulatory elements and examining the involved protein-DNA interactions.Fil: Sieira, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFuture Medicine2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18330Sieira, Rodrigo; Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter; Future Medicine; Future Microbiology; 8; 9; 9-2013; 1193-12081746-09131746-0921CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/pdf/10.2217/fmb.13.83info:eu-repo/semantics/altIdentifier/doi/10.2217/fmb.13.83info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:09Zoai:ri.conicet.gov.ar:11336/18330instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:10.002CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter
title Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter
spellingShingle Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter
Sieira, Rodrigo
Brucella
Type Iv Secretion System
Virb
Regulation
title_short Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter
title_full Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter
title_fullStr Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter
title_full_unstemmed Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter
title_sort Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter
dc.creator.none.fl_str_mv Sieira, Rodrigo
author Sieira, Rodrigo
author_facet Sieira, Rodrigo
author_role author
dc.subject.none.fl_str_mv Brucella
Type Iv Secretion System
Virb
Regulation
topic Brucella
Type Iv Secretion System
Virb
Regulation
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Many intracellular bacterial pathogens use type IV secretion systems to deliver effector molecules and subvert the eukaryotic host cell defenses. The genus Brucella comprises facultative intracellular bacteria that cause brucellosis, a disease affecting a wide range of mammals including humans. The virB operon codes for a type IV secretion system that plays a central role in intracellular survival and replication of Brucella within the host. Expression of the virB genes is under the control of various transcription factors that allow this system to respond to different types of environmental signals, and display binding site structures and arrangements that define the intrinsic complexity of the virB promoter. This review focuses on summarizing the current state of research concerning regulation of the Brucella virB operon, with special emphasis on describing the nature and function of the implicated regulatory elements and examining the involved protein-DNA interactions.
Fil: Sieira, Rodrigo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
description Many intracellular bacterial pathogens use type IV secretion systems to deliver effector molecules and subvert the eukaryotic host cell defenses. The genus Brucella comprises facultative intracellular bacteria that cause brucellosis, a disease affecting a wide range of mammals including humans. The virB operon codes for a type IV secretion system that plays a central role in intracellular survival and replication of Brucella within the host. Expression of the virB genes is under the control of various transcription factors that allow this system to respond to different types of environmental signals, and display binding site structures and arrangements that define the intrinsic complexity of the virB promoter. This review focuses on summarizing the current state of research concerning regulation of the Brucella virB operon, with special emphasis on describing the nature and function of the implicated regulatory elements and examining the involved protein-DNA interactions.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/18330
Sieira, Rodrigo; Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter; Future Medicine; Future Microbiology; 8; 9; 9-2013; 1193-1208
1746-0913
1746-0921
CONICET Digital
CONICET
url http://hdl.handle.net/11336/18330
identifier_str_mv Sieira, Rodrigo; Regulation of virulence in Brucella: an eclectic repertoire of transcription factors defines the complex architecture of the virB promoter; Future Medicine; Future Microbiology; 8; 9; 9-2013; 1193-1208
1746-0913
1746-0921
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.futuremedicine.com/doi/pdf/10.2217/fmb.13.83
info:eu-repo/semantics/altIdentifier/doi/10.2217/fmb.13.83
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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