Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.

Autores
Milesi, Maria Mercedes; Varayoud, Jorgelina Guadalupe; Bosquiazzo, Veronica Lis; Muñoz de Toro, Monica Milagros; Luque, Enrique Hugo
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study investigates the effects of neonatal exposure to low doses of endosulfan on the expression of proteins regulating uterine development and differentiation. Female pups received vehicle, endosulfan (Endo6: 6μg/kg, Endo600: 600μg/kg) or diethylstilbestrol (DES: 0.2μg/kg) from postnatal day 1 (PND1) to PND7. The uterine expression of estrogen receptor alpha (ERα), progesterone receptor (PR), Hoxa10 and alpha smooth muscle actin (α-SMA) was detected by immunohistochemistry on PND8 (neonatal period) and PND21 (prepubertal period), to evaluate acute and short-term responses. ERα, Hoxa10 and α-SMA were induced in the Endo600 group in both ages, while a striking decrease in PR expression was detected in the prepubertal rats following each dose of endosulfan. DES treatment deregulated ERα and Hoxa10 uterine expression at each age. Studies are currently underway to investigate whether the dysregulation of steroid receptors, Hoxa10 and α-SMA observed following neonatal exposure to endosulfan affect uterine functions in adulthood.
Fil: Milesi, Maria Mercedes. Universidad Nacional del Litoral; Argentina
Fil: Varayoud, Jorgelina Guadalupe. Universidad Nacional del Litoral; Argentina
Fil: Bosquiazzo, Veronica Lis. Universidad Nacional del Litoral; Argentina
Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; Argentina
Fil: Luque, Enrique Hugo. Universidad Nacional del Litoral; Argentina
Materia
ALPHA-SMOOTH MUSCLE ACTIN
ENDOSULFAN
ESTROGEN RECEPTOR ALPHA
HOXA10
PROGESTERONE RECEPTOR
UTERUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96487
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96487
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.Milesi, Maria MercedesVarayoud, Jorgelina GuadalupeBosquiazzo, Veronica LisMuñoz de Toro, Monica MilagrosLuque, Enrique HugoALPHA-SMOOTH MUSCLE ACTINENDOSULFANESTROGEN RECEPTOR ALPHAHOXA10PROGESTERONE RECEPTORUTERUShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3This study investigates the effects of neonatal exposure to low doses of endosulfan on the expression of proteins regulating uterine development and differentiation. Female pups received vehicle, endosulfan (Endo6: 6μg/kg, Endo600: 600μg/kg) or diethylstilbestrol (DES: 0.2μg/kg) from postnatal day 1 (PND1) to PND7. The uterine expression of estrogen receptor alpha (ERα), progesterone receptor (PR), Hoxa10 and alpha smooth muscle actin (α-SMA) was detected by immunohistochemistry on PND8 (neonatal period) and PND21 (prepubertal period), to evaluate acute and short-term responses. ERα, Hoxa10 and α-SMA were induced in the Endo600 group in both ages, while a striking decrease in PR expression was detected in the prepubertal rats following each dose of endosulfan. DES treatment deregulated ERα and Hoxa10 uterine expression at each age. Studies are currently underway to investigate whether the dysregulation of steroid receptors, Hoxa10 and α-SMA observed following neonatal exposure to endosulfan affect uterine functions in adulthood.Fil: Milesi, Maria Mercedes. Universidad Nacional del Litoral; ArgentinaFil: Varayoud, Jorgelina Guadalupe. Universidad Nacional del Litoral; ArgentinaFil: Bosquiazzo, Veronica Lis. Universidad Nacional del Litoral; ArgentinaFil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; ArgentinaFil: Luque, Enrique Hugo. Universidad Nacional del Litoral; ArgentinaPergamon-Elsevier Science Ltd2012-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96487Milesi, Maria Mercedes; Varayoud, Jorgelina Guadalupe; Bosquiazzo, Veronica Lis; Muñoz de Toro, Monica Milagros; Luque, Enrique Hugo; Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 33; 1; 1-2012; 85-930890-6238CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.reprotox.2011.12.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:15Zoai:ri.conicet.gov.ar:11336/96487instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:16.249CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.
title Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.
spellingShingle Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.
Milesi, Maria Mercedes
ALPHA-SMOOTH MUSCLE ACTIN
ENDOSULFAN
ESTROGEN RECEPTOR ALPHA
HOXA10
PROGESTERONE RECEPTOR
UTERUS
title_short Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.
title_full Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.
title_fullStr Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.
title_full_unstemmed Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.
title_sort Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.
dc.creator.none.fl_str_mv Milesi, Maria Mercedes
Varayoud, Jorgelina Guadalupe
Bosquiazzo, Veronica Lis
Muñoz de Toro, Monica Milagros
Luque, Enrique Hugo
author Milesi, Maria Mercedes
author_facet Milesi, Maria Mercedes
Varayoud, Jorgelina Guadalupe
Bosquiazzo, Veronica Lis
Muñoz de Toro, Monica Milagros
Luque, Enrique Hugo
author_role author
author2 Varayoud, Jorgelina Guadalupe
Bosquiazzo, Veronica Lis
Muñoz de Toro, Monica Milagros
Luque, Enrique Hugo
author2_role author
author
author
author
dc.subject.none.fl_str_mv ALPHA-SMOOTH MUSCLE ACTIN
ENDOSULFAN
ESTROGEN RECEPTOR ALPHA
HOXA10
PROGESTERONE RECEPTOR
UTERUS
topic ALPHA-SMOOTH MUSCLE ACTIN
ENDOSULFAN
ESTROGEN RECEPTOR ALPHA
HOXA10
PROGESTERONE RECEPTOR
UTERUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This study investigates the effects of neonatal exposure to low doses of endosulfan on the expression of proteins regulating uterine development and differentiation. Female pups received vehicle, endosulfan (Endo6: 6μg/kg, Endo600: 600μg/kg) or diethylstilbestrol (DES: 0.2μg/kg) from postnatal day 1 (PND1) to PND7. The uterine expression of estrogen receptor alpha (ERα), progesterone receptor (PR), Hoxa10 and alpha smooth muscle actin (α-SMA) was detected by immunohistochemistry on PND8 (neonatal period) and PND21 (prepubertal period), to evaluate acute and short-term responses. ERα, Hoxa10 and α-SMA were induced in the Endo600 group in both ages, while a striking decrease in PR expression was detected in the prepubertal rats following each dose of endosulfan. DES treatment deregulated ERα and Hoxa10 uterine expression at each age. Studies are currently underway to investigate whether the dysregulation of steroid receptors, Hoxa10 and α-SMA observed following neonatal exposure to endosulfan affect uterine functions in adulthood.
Fil: Milesi, Maria Mercedes. Universidad Nacional del Litoral; Argentina
Fil: Varayoud, Jorgelina Guadalupe. Universidad Nacional del Litoral; Argentina
Fil: Bosquiazzo, Veronica Lis. Universidad Nacional del Litoral; Argentina
Fil: Muñoz de Toro, Monica Milagros. Universidad Nacional del Litoral; Argentina
Fil: Luque, Enrique Hugo. Universidad Nacional del Litoral; Argentina
description This study investigates the effects of neonatal exposure to low doses of endosulfan on the expression of proteins regulating uterine development and differentiation. Female pups received vehicle, endosulfan (Endo6: 6μg/kg, Endo600: 600μg/kg) or diethylstilbestrol (DES: 0.2μg/kg) from postnatal day 1 (PND1) to PND7. The uterine expression of estrogen receptor alpha (ERα), progesterone receptor (PR), Hoxa10 and alpha smooth muscle actin (α-SMA) was detected by immunohistochemistry on PND8 (neonatal period) and PND21 (prepubertal period), to evaluate acute and short-term responses. ERα, Hoxa10 and α-SMA were induced in the Endo600 group in both ages, while a striking decrease in PR expression was detected in the prepubertal rats following each dose of endosulfan. DES treatment deregulated ERα and Hoxa10 uterine expression at each age. Studies are currently underway to investigate whether the dysregulation of steroid receptors, Hoxa10 and α-SMA observed following neonatal exposure to endosulfan affect uterine functions in adulthood.
publishDate 2012
dc.date.none.fl_str_mv 2012-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96487
Milesi, Maria Mercedes; Varayoud, Jorgelina Guadalupe; Bosquiazzo, Veronica Lis; Muñoz de Toro, Monica Milagros; Luque, Enrique Hugo; Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 33; 1; 1-2012; 85-93
0890-6238
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96487
identifier_str_mv Milesi, Maria Mercedes; Varayoud, Jorgelina Guadalupe; Bosquiazzo, Veronica Lis; Muñoz de Toro, Monica Milagros; Luque, Enrique Hugo; Neonatal exposure to low doses of endosulfan disrupts the expression of proteins regulating uterine development and differentiation.; Pergamon-Elsevier Science Ltd; Reproductive Toxicology; 33; 1; 1-2012; 85-93
0890-6238
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.reprotox.2011.12.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268846885437440
score 13.13397

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