Ultrasensitivity in (SUPRA)molecularly organized and crowded environments

Autores
Aon, Miguel A.; Gomez Casati, Diego Fabian; Iglesias, Alberto Alvaro; Cortassa, Sonia del Carmen
Año de publicación
2001
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.
Fil: Aon, Miguel A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. University Johns Hopkins; Estados Unidos
Fil: Gomez Casati, Diego Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Iglesias, Alberto Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Cortassa, Sonia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Materia
CROWDING
CYTOSKELETON
METABOLIC PATHWAYS
SIGNALLING CASCADES
ULTRASENSITIVITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85678
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/85678
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Ultrasensitivity in (SUPRA)molecularly organized and crowded environmentsAon, Miguel A.Gomez Casati, Diego FabianIglesias, Alberto AlvaroCortassa, Sonia del CarmenCROWDINGCYTOSKELETONMETABOLIC PATHWAYSSIGNALLING CASCADESULTRASENSITIVITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.Fil: Aon, Miguel A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. University Johns Hopkins; Estados UnidosFil: Gomez Casati, Diego Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Iglesias, Alberto Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Cortassa, Sonia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaAcademic Press Ltd - Elsevier Science Ltd2001-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85678Aon, Miguel A.; Gomez Casati, Diego Fabian; Iglesias, Alberto Alvaro; Cortassa, Sonia del Carmen; Ultrasensitivity in (SUPRA)molecularly organized and crowded environments; Academic Press Ltd - Elsevier Science Ltd; Cell Biology International; 25; 11; 12-2001; 1091-10991065-6995CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1006/cbir.2001.0804info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:50Zoai:ri.conicet.gov.ar:11336/85678instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:50.49CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ultrasensitivity in (SUPRA)molecularly organized and crowded environments
title Ultrasensitivity in (SUPRA)molecularly organized and crowded environments
spellingShingle Ultrasensitivity in (SUPRA)molecularly organized and crowded environments
Aon, Miguel A.
CROWDING
CYTOSKELETON
METABOLIC PATHWAYS
SIGNALLING CASCADES
ULTRASENSITIVITY
title_short Ultrasensitivity in (SUPRA)molecularly organized and crowded environments
title_full Ultrasensitivity in (SUPRA)molecularly organized and crowded environments
title_fullStr Ultrasensitivity in (SUPRA)molecularly organized and crowded environments
title_full_unstemmed Ultrasensitivity in (SUPRA)molecularly organized and crowded environments
title_sort Ultrasensitivity in (SUPRA)molecularly organized and crowded environments
dc.creator.none.fl_str_mv Aon, Miguel A.
Gomez Casati, Diego Fabian
Iglesias, Alberto Alvaro
Cortassa, Sonia del Carmen
author Aon, Miguel A.
author_facet Aon, Miguel A.
Gomez Casati, Diego Fabian
Iglesias, Alberto Alvaro
Cortassa, Sonia del Carmen
author_role author
author2 Gomez Casati, Diego Fabian
Iglesias, Alberto Alvaro
Cortassa, Sonia del Carmen
author2_role author
author
author
dc.subject.none.fl_str_mv CROWDING
CYTOSKELETON
METABOLIC PATHWAYS
SIGNALLING CASCADES
ULTRASENSITIVITY
topic CROWDING
CYTOSKELETON
METABOLIC PATHWAYS
SIGNALLING CASCADES
ULTRASENSITIVITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.
Fil: Aon, Miguel A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina. University Johns Hopkins; Estados Unidos
Fil: Gomez Casati, Diego Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
Fil: Iglesias, Alberto Alvaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; Argentina
Fil: Cortassa, Sonia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
description The ultrasensitive response of biological systems is a more sensitive one than that expected from the classical hyperbola of Michaelis-Menten kinetics, and whose physiological relevance depends upon the range of variation of substrate or effector for which ultrasensitivity is observed. Triggering and modulation of the ultrasensitive response in enzymatic and cellular systems are reviewed. Several demonstrations of ultrasensitive behavior in cellular systems and its impact on the amplification properties in signalling cascades and metabolic pathways are also highlighted. It is shown that ubiquitous cytoskeletal proteins may up- or downmodulate ultrasensitivity under physico-chemical conditions resembling those predominant in cells.
publishDate 2001
dc.date.none.fl_str_mv 2001-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85678
Aon, Miguel A.; Gomez Casati, Diego Fabian; Iglesias, Alberto Alvaro; Cortassa, Sonia del Carmen; Ultrasensitivity in (SUPRA)molecularly organized and crowded environments; Academic Press Ltd - Elsevier Science Ltd; Cell Biology International; 25; 11; 12-2001; 1091-1099
1065-6995
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85678
identifier_str_mv Aon, Miguel A.; Gomez Casati, Diego Fabian; Iglesias, Alberto Alvaro; Cortassa, Sonia del Carmen; Ultrasensitivity in (SUPRA)molecularly organized and crowded environments; Academic Press Ltd - Elsevier Science Ltd; Cell Biology International; 25; 11; 12-2001; 1091-1099
1065-6995
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1006/cbir.2001.0804
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
publisher.none.fl_str_mv Academic Press Ltd - Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613858623225856
score 13.070432

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