Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100

Autores
Ardusso, Marina Silvana; Manzo, Ruben Hilario; Jimenez Kairuz, Alvaro Federico
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A detailed description of equilibrium and drug release properties of aqueous dispersions of complexes of model basic drugs (D) with three structurally related acid polyelectrolytes (PE) is reported. Thus, equilibrium properties of dispersions of polymetacrylates Eudragit L 100, and Eudragit S 100, neutralized with increasing proportions of Lidocaine, Metoclopramide and Atenolol, were compared with those of Carbomer that were previously reported. The proportions of PE condensed (RCOO-DH+) and free species (D and DH+) were determined on PE-Lidocaine and PE-Metoclopramide systems. Affinity constants for ionic pair formation (Kip) were calculated as a function of D loading. In agreement with the high degree of counterionic condensation observed, the three (PE-D) complexes placed on Franz type cells released D at slow rates as water was the receptor medium. Rates increased over 3 times as water was replaced by 0.9% NaCl solution. Similar average of Korsmeyer exponent n (0.61 (water) and 0.69 (NaCl)) were found in both media. The overall kinetic behavior suggests that, under the conditions assayed, the dissociation of RCOO-DH+ is the factor that controls releasing rates. Structure related properties of the PE-D systems were identified in order to expand their potential uses as drug carriers.
Fil: Ardusso, Marina Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
Polyelectrolyte-drug complexes
Ionic pairs
Affinity
Species distribution
Drug release
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/129872
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/129872
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100Ardusso, Marina SilvanaManzo, Ruben HilarioJimenez Kairuz, Alvaro FedericoPolyelectrolyte-drug complexesIonic pairsAffinitySpecies distributionDrug releasehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3A detailed description of equilibrium and drug release properties of aqueous dispersions of complexes of model basic drugs (D) with three structurally related acid polyelectrolytes (PE) is reported. Thus, equilibrium properties of dispersions of polymetacrylates Eudragit L 100, and Eudragit S 100, neutralized with increasing proportions of Lidocaine, Metoclopramide and Atenolol, were compared with those of Carbomer that were previously reported. The proportions of PE condensed (RCOO-DH+) and free species (D and DH+) were determined on PE-Lidocaine and PE-Metoclopramide systems. Affinity constants for ionic pair formation (Kip) were calculated as a function of D loading. In agreement with the high degree of counterionic condensation observed, the three (PE-D) complexes placed on Franz type cells released D at slow rates as water was the receptor medium. Rates increased over 3 times as water was replaced by 0.9% NaCl solution. Similar average of Korsmeyer exponent n (0.61 (water) and 0.69 (NaCl)) were found in both media. The overall kinetic behavior suggests that, under the conditions assayed, the dissociation of RCOO-DH+ is the factor that controls releasing rates. Structure related properties of the PE-D systems were identified in order to expand their potential uses as drug carriers.Fil: Ardusso, Marina Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Manzo, Ruben Hilario. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaTaylor & Francis Ltd2010-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129872Ardusso, Marina Silvana; Manzo, Ruben Hilario; Jimenez Kairuz, Alvaro Federico; Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100; Taylor & Francis Ltd; Supramolecular Chemistry; 22; 5; 5-2010; 289-2961061-02781029-0478CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1080/10610270903469757info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/10610270903469757info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:37:38Zoai:ri.conicet.gov.ar:11336/129872instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:37:38.315CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
title Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
spellingShingle Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
Ardusso, Marina Silvana
Polyelectrolyte-drug complexes
Ionic pairs
Affinity
Species distribution
Drug release
title_short Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
title_full Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
title_fullStr Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
title_full_unstemmed Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
title_sort Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100
dc.creator.none.fl_str_mv Ardusso, Marina Silvana
Manzo, Ruben Hilario
Jimenez Kairuz, Alvaro Federico
author Ardusso, Marina Silvana
author_facet Ardusso, Marina Silvana
Manzo, Ruben Hilario
Jimenez Kairuz, Alvaro Federico
author_role author
author2 Manzo, Ruben Hilario
Jimenez Kairuz, Alvaro Federico
author2_role author
author
dc.subject.none.fl_str_mv Polyelectrolyte-drug complexes
Ionic pairs
Affinity
Species distribution
Drug release
topic Polyelectrolyte-drug complexes
Ionic pairs
Affinity
Species distribution
Drug release
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A detailed description of equilibrium and drug release properties of aqueous dispersions of complexes of model basic drugs (D) with three structurally related acid polyelectrolytes (PE) is reported. Thus, equilibrium properties of dispersions of polymetacrylates Eudragit L 100, and Eudragit S 100, neutralized with increasing proportions of Lidocaine, Metoclopramide and Atenolol, were compared with those of Carbomer that were previously reported. The proportions of PE condensed (RCOO-DH+) and free species (D and DH+) were determined on PE-Lidocaine and PE-Metoclopramide systems. Affinity constants for ionic pair formation (Kip) were calculated as a function of D loading. In agreement with the high degree of counterionic condensation observed, the three (PE-D) complexes placed on Franz type cells released D at slow rates as water was the receptor medium. Rates increased over 3 times as water was replaced by 0.9% NaCl solution. Similar average of Korsmeyer exponent n (0.61 (water) and 0.69 (NaCl)) were found in both media. The overall kinetic behavior suggests that, under the conditions assayed, the dissociation of RCOO-DH+ is the factor that controls releasing rates. Structure related properties of the PE-D systems were identified in order to expand their potential uses as drug carriers.
Fil: Ardusso, Marina Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Jimenez Kairuz, Alvaro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description A detailed description of equilibrium and drug release properties of aqueous dispersions of complexes of model basic drugs (D) with three structurally related acid polyelectrolytes (PE) is reported. Thus, equilibrium properties of dispersions of polymetacrylates Eudragit L 100, and Eudragit S 100, neutralized with increasing proportions of Lidocaine, Metoclopramide and Atenolol, were compared with those of Carbomer that were previously reported. The proportions of PE condensed (RCOO-DH+) and free species (D and DH+) were determined on PE-Lidocaine and PE-Metoclopramide systems. Affinity constants for ionic pair formation (Kip) were calculated as a function of D loading. In agreement with the high degree of counterionic condensation observed, the three (PE-D) complexes placed on Franz type cells released D at slow rates as water was the receptor medium. Rates increased over 3 times as water was replaced by 0.9% NaCl solution. Similar average of Korsmeyer exponent n (0.61 (water) and 0.69 (NaCl)) were found in both media. The overall kinetic behavior suggests that, under the conditions assayed, the dissociation of RCOO-DH+ is the factor that controls releasing rates. Structure related properties of the PE-D systems were identified in order to expand their potential uses as drug carriers.
publishDate 2010
dc.date.none.fl_str_mv 2010-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/129872
Ardusso, Marina Silvana; Manzo, Ruben Hilario; Jimenez Kairuz, Alvaro Federico; Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100; Taylor & Francis Ltd; Supramolecular Chemistry; 22; 5; 5-2010; 289-296
1061-0278
1029-0478
CONICET Digital
CONICET
url http://hdl.handle.net/11336/129872
identifier_str_mv Ardusso, Marina Silvana; Manzo, Ruben Hilario; Jimenez Kairuz, Alvaro Federico; Comparative study of three structurally related acid polyelectrolytes as carriers of basic drugs: Carbomer, Eudragit L 100 and Eudragit S 100; Taylor & Francis Ltd; Supramolecular Chemistry; 22; 5; 5-2010; 289-296
1061-0278
1029-0478
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1080/10610270903469757
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/10610270903469757
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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