Common variable immunodeficiency and circulating TFH

Autores
Coraglia, Ana Carina; Galassi, Nora Virginia; Fernández Romero, Diego S.; Juri, M. Cecilia; Felippo, Marta Elena; Malbrán, Alejandro; de Bracco, Maria M. E.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
CD4+ T follicular helper cells () were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II). lymphocytes were characterized by expression of CXCR5 and PD-1. were higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N). Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg and reg were similar in both CVID groups and in N. responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression of cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. These results suggest that are functional in CVID and highlight the association of increased circulating with AI and GD manifestations.
Fil: Coraglia, Ana Carina. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Galassi, Nora Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Fernández Romero, Diego S.. Unidad de Alergia, Asma e Inmunología Clínica; Argentina
Fil: Juri, M. Cecilia. Unidad de Alergia, Asma e Inmunología Clínica; Argentina
Fil: Felippo, Marta Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Malbrán, Alejandro. Unidad de Alergia, Asma e Inmunología Clínica; Argentina
Fil: de Bracco, Maria M. E.. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Materia
Cvid
B Lymphocytes
Circulating Tfh
Icos-Cd40l
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40551
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Common variable immunodeficiency and circulating TFHCoraglia, Ana CarinaGalassi, Nora VirginiaFernández Romero, Diego S.Juri, M. CeciliaFelippo, Marta ElenaMalbrán, Alejandrode Bracco, Maria M. E.CvidB LymphocytesCirculating TfhIcos-Cd40lhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3CD4+ T follicular helper cells () were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II). lymphocytes were characterized by expression of CXCR5 and PD-1. were higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N). Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg and reg were similar in both CVID groups and in N. responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression of cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. These results suggest that are functional in CVID and highlight the association of increased circulating with AI and GD manifestations.Fil: Coraglia, Ana Carina. Academia Nacional de Medicina de Buenos Aires; ArgentinaFil: Galassi, Nora Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Fernández Romero, Diego S.. Unidad de Alergia, Asma e Inmunología Clínica; ArgentinaFil: Juri, M. Cecilia. Unidad de Alergia, Asma e Inmunología Clínica; ArgentinaFil: Felippo, Marta Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Malbrán, Alejandro. Unidad de Alergia, Asma e Inmunología Clínica; ArgentinaFil: de Bracco, Maria M. E.. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaHindawi2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40551Coraglia, Ana Carina; Galassi, Nora Virginia; Fernández Romero, Diego S.; Juri, M. Cecilia; Felippo, Marta Elena; et al.; Common variable immunodeficiency and circulating TFH; Hindawi; Journal of Immunology Research; 2016; 4-2016; 1-102314-8861CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1155/2016/4951587info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jir/2016/4951587/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:54Zoai:ri.conicet.gov.ar:11336/40551instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:54.347CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Common variable immunodeficiency and circulating TFH
title Common variable immunodeficiency and circulating TFH
spellingShingle Common variable immunodeficiency and circulating TFH
Coraglia, Ana Carina
Cvid
B Lymphocytes
Circulating Tfh
Icos-Cd40l
title_short Common variable immunodeficiency and circulating TFH
title_full Common variable immunodeficiency and circulating TFH
title_fullStr Common variable immunodeficiency and circulating TFH
title_full_unstemmed Common variable immunodeficiency and circulating TFH
title_sort Common variable immunodeficiency and circulating TFH
dc.creator.none.fl_str_mv Coraglia, Ana Carina
Galassi, Nora Virginia
Fernández Romero, Diego S.
Juri, M. Cecilia
Felippo, Marta Elena
Malbrán, Alejandro
de Bracco, Maria M. E.
author Coraglia, Ana Carina
author_facet Coraglia, Ana Carina
Galassi, Nora Virginia
Fernández Romero, Diego S.
Juri, M. Cecilia
Felippo, Marta Elena
Malbrán, Alejandro
de Bracco, Maria M. E.
author_role author
author2 Galassi, Nora Virginia
Fernández Romero, Diego S.
Juri, M. Cecilia
Felippo, Marta Elena
Malbrán, Alejandro
de Bracco, Maria M. E.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Cvid
B Lymphocytes
Circulating Tfh
Icos-Cd40l
topic Cvid
B Lymphocytes
Circulating Tfh
Icos-Cd40l
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv CD4+ T follicular helper cells () were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II). lymphocytes were characterized by expression of CXCR5 and PD-1. were higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N). Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg and reg were similar in both CVID groups and in N. responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression of cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. These results suggest that are functional in CVID and highlight the association of increased circulating with AI and GD manifestations.
Fil: Coraglia, Ana Carina. Academia Nacional de Medicina de Buenos Aires; Argentina
Fil: Galassi, Nora Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Fernández Romero, Diego S.. Unidad de Alergia, Asma e Inmunología Clínica; Argentina
Fil: Juri, M. Cecilia. Unidad de Alergia, Asma e Inmunología Clínica; Argentina
Fil: Felippo, Marta Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Malbrán, Alejandro. Unidad de Alergia, Asma e Inmunología Clínica; Argentina
Fil: de Bracco, Maria M. E.. Academia Nacional de Medicina de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
description CD4+ T follicular helper cells () were assessed in adult patients with common variable immune deficiency (CVID) classified according to the presence of granulomatous disease (GD), autoimmunity (AI), or both GD and AI (Group I) or the absence of AI and GD (Group II). lymphocytes were characterized by expression of CXCR5 and PD-1. were higher (in both absolute number and percentage) in Group I than in Group II CVID patients and normal controls (N). Within CXCR5+CD4+ T cells, the percentage of PD-1 (+) was higher and that of CCR7 (+) was lower in Group I than in Group II and N. The percentages of Treg and reg were similar in both CVID groups and in N. responded to stimulation increasing the expression of the costimulatory molecules CD40L and ICOS as did N. After submitogenic PHA+IL-2 stimulation, intracellular expression of cytokines (IL-10, IL-21) was higher than N in Group I, and IL-4 was higher than N in Group II. These results suggest that are functional in CVID and highlight the association of increased circulating with AI and GD manifestations.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40551
Coraglia, Ana Carina; Galassi, Nora Virginia; Fernández Romero, Diego S.; Juri, M. Cecilia; Felippo, Marta Elena; et al.; Common variable immunodeficiency and circulating TFH; Hindawi; Journal of Immunology Research; 2016; 4-2016; 1-10
2314-8861
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40551
identifier_str_mv Coraglia, Ana Carina; Galassi, Nora Virginia; Fernández Romero, Diego S.; Juri, M. Cecilia; Felippo, Marta Elena; et al.; Common variable immunodeficiency and circulating TFH; Hindawi; Journal of Immunology Research; 2016; 4-2016; 1-10
2314-8861
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1155/2016/4951587
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jir/2016/4951587/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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