Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles

Autores
Patriarca, Matías Ezequiel; Lombardelli, Marcelo Miguel; Pellegri, Nora Susana; Daier, Veronica Andrea; Signorella, Sandra Rosanna
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The imidazolate-bridged diCu(ii) complex [Cu2(dien)2(μ-Im)]3+ (Im = imidazolate, dien = diethylenetriamine) was encapsulated in mesoporous spherical silica particles (MSSP) with retention of the morphology and mesostructure of the guest-free silica particles. This hybrid material catalyzes the dismutation of superoxide efficiently, with second-order catalytic rate constant of 8.28 × 107 M−1 s−1, obtained from the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, at pH = 7.8. The small silica channels of MSSP (wp = 2.7 nm) enhance the distortion of the Cu(ii) local environment compared to mesoporous silicas with wider pores and ensure the two metal moieties of the reduced catalyst remain in close proximity to react with superoxide. These two combined effects increase the SOD activity of the hybrid material ten times over the free catalyst. The small channel size is also relevant for the salpn derived functional SOD mimic [CuZn(salpn)Cl2] (H2salpn = 1,3-bis(salicylideneamino)propane), which upon encapsulation in MSSP doubles its SOD activity.
Fil: Patriarca, Matías Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Lombardelli, Marcelo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Pellegri, Nora Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina
Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Materia
NANOMATERIALS
SILICA
CATALYSIS
Cu COMPLEX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/255318
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/255318
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particlesPatriarca, Matías EzequielLombardelli, Marcelo MiguelPellegri, Nora SusanaDaier, Veronica AndreaSignorella, Sandra RosannaNANOMATERIALSSILICACATALYSISCu COMPLEXhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The imidazolate-bridged diCu(ii) complex [Cu2(dien)2(μ-Im)]3+ (Im = imidazolate, dien = diethylenetriamine) was encapsulated in mesoporous spherical silica particles (MSSP) with retention of the morphology and mesostructure of the guest-free silica particles. This hybrid material catalyzes the dismutation of superoxide efficiently, with second-order catalytic rate constant of 8.28 × 107 M−1 s−1, obtained from the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, at pH = 7.8. The small silica channels of MSSP (wp = 2.7 nm) enhance the distortion of the Cu(ii) local environment compared to mesoporous silicas with wider pores and ensure the two metal moieties of the reduced catalyst remain in close proximity to react with superoxide. These two combined effects increase the SOD activity of the hybrid material ten times over the free catalyst. The small channel size is also relevant for the salpn derived functional SOD mimic [CuZn(salpn)Cl2] (H2salpn = 1,3-bis(salicylideneamino)propane), which upon encapsulation in MSSP doubles its SOD activity.Fil: Patriarca, Matías Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Lombardelli, Marcelo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Pellegri, Nora Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaRoyal Society of Chemistry2023-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/255318Patriarca, Matías Ezequiel; Lombardelli, Marcelo Miguel; Pellegri, Nora Susana; Daier, Veronica Andrea; Signorella, Sandra Rosanna; Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles; Royal Society of Chemistry; New Journal of Chemistry; 47; 45; 10-2023; 20800-208061144-0546CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2023/nj/d3nj03688jinfo:eu-repo/semantics/altIdentifier/doi/10.1039/D3NJ03688Jinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:38:53Zoai:ri.conicet.gov.ar:11336/255318instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:38:53.544CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles
title Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles
spellingShingle Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles
Patriarca, Matías Ezequiel
NANOMATERIALS
SILICA
CATALYSIS
Cu COMPLEX
title_short Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles
title_full Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles
title_fullStr Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles
title_full_unstemmed Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles
title_sort Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles
dc.creator.none.fl_str_mv Patriarca, Matías Ezequiel
Lombardelli, Marcelo Miguel
Pellegri, Nora Susana
Daier, Veronica Andrea
Signorella, Sandra Rosanna
author Patriarca, Matías Ezequiel
author_facet Patriarca, Matías Ezequiel
Lombardelli, Marcelo Miguel
Pellegri, Nora Susana
Daier, Veronica Andrea
Signorella, Sandra Rosanna
author_role author
author2 Lombardelli, Marcelo Miguel
Pellegri, Nora Susana
Daier, Veronica Andrea
Signorella, Sandra Rosanna
author2_role author
author
author
author
dc.subject.none.fl_str_mv NANOMATERIALS
SILICA
CATALYSIS
Cu COMPLEX
topic NANOMATERIALS
SILICA
CATALYSIS
Cu COMPLEX
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The imidazolate-bridged diCu(ii) complex [Cu2(dien)2(μ-Im)]3+ (Im = imidazolate, dien = diethylenetriamine) was encapsulated in mesoporous spherical silica particles (MSSP) with retention of the morphology and mesostructure of the guest-free silica particles. This hybrid material catalyzes the dismutation of superoxide efficiently, with second-order catalytic rate constant of 8.28 × 107 M−1 s−1, obtained from the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, at pH = 7.8. The small silica channels of MSSP (wp = 2.7 nm) enhance the distortion of the Cu(ii) local environment compared to mesoporous silicas with wider pores and ensure the two metal moieties of the reduced catalyst remain in close proximity to react with superoxide. These two combined effects increase the SOD activity of the hybrid material ten times over the free catalyst. The small channel size is also relevant for the salpn derived functional SOD mimic [CuZn(salpn)Cl2] (H2salpn = 1,3-bis(salicylideneamino)propane), which upon encapsulation in MSSP doubles its SOD activity.
Fil: Patriarca, Matías Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Lombardelli, Marcelo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Pellegri, Nora Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentina
Fil: Daier, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Signorella, Sandra Rosanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
description The imidazolate-bridged diCu(ii) complex [Cu2(dien)2(μ-Im)]3+ (Im = imidazolate, dien = diethylenetriamine) was encapsulated in mesoporous spherical silica particles (MSSP) with retention of the morphology and mesostructure of the guest-free silica particles. This hybrid material catalyzes the dismutation of superoxide efficiently, with second-order catalytic rate constant of 8.28 × 107 M−1 s−1, obtained from the nitro blue tetrazolium photoreduction inhibition superoxide dismutase assay, at pH = 7.8. The small silica channels of MSSP (wp = 2.7 nm) enhance the distortion of the Cu(ii) local environment compared to mesoporous silicas with wider pores and ensure the two metal moieties of the reduced catalyst remain in close proximity to react with superoxide. These two combined effects increase the SOD activity of the hybrid material ten times over the free catalyst. The small channel size is also relevant for the salpn derived functional SOD mimic [CuZn(salpn)Cl2] (H2salpn = 1,3-bis(salicylideneamino)propane), which upon encapsulation in MSSP doubles its SOD activity.
publishDate 2023
dc.date.none.fl_str_mv 2023-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/255318
Patriarca, Matías Ezequiel; Lombardelli, Marcelo Miguel; Pellegri, Nora Susana; Daier, Veronica Andrea; Signorella, Sandra Rosanna; Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles; Royal Society of Chemistry; New Journal of Chemistry; 47; 45; 10-2023; 20800-20806
1144-0546
CONICET Digital
CONICET
url http://hdl.handle.net/11336/255318
identifier_str_mv Patriarca, Matías Ezequiel; Lombardelli, Marcelo Miguel; Pellegri, Nora Susana; Daier, Veronica Andrea; Signorella, Sandra Rosanna; Exploring the effect of pore size on the activity of superoxide dismutase mimics immobilized in mesoporous spherical silica particles; Royal Society of Chemistry; New Journal of Chemistry; 47; 45; 10-2023; 20800-20806
1144-0546
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2023/nj/d3nj03688j
info:eu-repo/semantics/altIdentifier/doi/10.1039/D3NJ03688J
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.976206

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