Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients

Autores
Katz, Marcelo E.; Margulis, Fernando; Schiavelli, Rubén; Arias, Pablo; Head, Geoffrey A.; Golombek, Diego Andres
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Patients with kidney replacement exhibit disrupted circadian rhythms. Most studies measuring blood pressure use the dipper/non-dipper classification, which does not consider analysis of transitional stages between low and high blood pressure, confidence intervals nor shifts in the time of peak, while assuming subjective onsets of night and day phases. In order to better understand the nature of daily variation of blood pressure in these patients, we analyzed 24 h recordings from 41 renal transplant recipients using the non-symmetrical double-logistic fitting assessment which does not assume abruptness nor symmetry in ascending and descending stages of the blood pressure profile, and a cosine best-fitting regression method (Cosinor). Compared with matched controls, double-logistic fitting showed that the times for most transitional stages (ascending systolic and descending systolic, diastolic, and mean arterial pressure) had a wider distribution along the 24-h. The proportion of individuals without daily blood pressure rhythm in the transplanted group was larger only for systolic arterial pressure, and the amplitude showed no significant difference. Furthermore, the transplant recipient group had a less pronounced slope in descending systolic and ascending mean blood pressure. Cosinor analysis confirmed this phase-related changes, showing a wider distribution of times of peak (acrophases). We conclude that daily disruptions in renal transplant recipients can be explained not necessarily by an absence in diurnal variation, but also by changes in waveform-related parameters of the rhythm, and that alterations in the phase of the rhythm are the most consistent finding in these patients.
Fil: Katz, Marcelo E.. Universidad Nacional de Quilmes; Argentina
Fil: Margulis, Fernando. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina
Fil: Schiavelli, Rubén. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina
Fil: Arias, Pablo. Universidad de Buenos Aires; Argentina
Fil: Head, Geoffrey A.. No especifíca;
Fil: Golombek, Diego Andres. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
AMBULATORY BLOOD PRESSURE MONITORING
COSINOR
DAILY RHYTHM
KIDNEY TRANSPLANTATION
NON-SYMMETRICAL DOUBLE-LOGISTIC ANALYSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/194719
Acceder
id CONICETDig_8841b65997a42c17f650925be8f115f4
oai_identifier_str oai:ri.conicet.gov.ar:11336/194719
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipientsKatz, Marcelo E.Margulis, FernandoSchiavelli, RubénArias, PabloHead, Geoffrey A.Golombek, Diego AndresAMBULATORY BLOOD PRESSURE MONITORINGCOSINORDAILY RHYTHMKIDNEY TRANSPLANTATIONNON-SYMMETRICAL DOUBLE-LOGISTIC ANALYSIShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Patients with kidney replacement exhibit disrupted circadian rhythms. Most studies measuring blood pressure use the dipper/non-dipper classification, which does not consider analysis of transitional stages between low and high blood pressure, confidence intervals nor shifts in the time of peak, while assuming subjective onsets of night and day phases. In order to better understand the nature of daily variation of blood pressure in these patients, we analyzed 24 h recordings from 41 renal transplant recipients using the non-symmetrical double-logistic fitting assessment which does not assume abruptness nor symmetry in ascending and descending stages of the blood pressure profile, and a cosine best-fitting regression method (Cosinor). Compared with matched controls, double-logistic fitting showed that the times for most transitional stages (ascending systolic and descending systolic, diastolic, and mean arterial pressure) had a wider distribution along the 24-h. The proportion of individuals without daily blood pressure rhythm in the transplanted group was larger only for systolic arterial pressure, and the amplitude showed no significant difference. Furthermore, the transplant recipient group had a less pronounced slope in descending systolic and ascending mean blood pressure. Cosinor analysis confirmed this phase-related changes, showing a wider distribution of times of peak (acrophases). We conclude that daily disruptions in renal transplant recipients can be explained not necessarily by an absence in diurnal variation, but also by changes in waveform-related parameters of the rhythm, and that alterations in the phase of the rhythm are the most consistent finding in these patients.Fil: Katz, Marcelo E.. Universidad Nacional de Quilmes; ArgentinaFil: Margulis, Fernando. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; ArgentinaFil: Schiavelli, Rubén. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; ArgentinaFil: Arias, Pablo. Universidad de Buenos Aires; ArgentinaFil: Head, Geoffrey A.. No especifíca;Fil: Golombek, Diego Andres. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFrontiers Media2012-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/194719Katz, Marcelo E.; Margulis, Fernando; Schiavelli, Rubén; Arias, Pablo; Head, Geoffrey A.; et al.; Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients; Frontiers Media; Frontiers in Neurology; 3; 3-2012; 35-431664-2295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2012.00035/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2012.00035info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:10:55Zoai:ri.conicet.gov.ar:11336/194719instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:10:55.331CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients
title Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients
spellingShingle Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients
Katz, Marcelo E.
AMBULATORY BLOOD PRESSURE MONITORING
COSINOR
DAILY RHYTHM
KIDNEY TRANSPLANTATION
NON-SYMMETRICAL DOUBLE-LOGISTIC ANALYSIS
title_short Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients
title_full Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients
title_fullStr Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients
title_full_unstemmed Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients
title_sort Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients
dc.creator.none.fl_str_mv Katz, Marcelo E.
Margulis, Fernando
Schiavelli, Rubén
Arias, Pablo
Head, Geoffrey A.
Golombek, Diego Andres
author Katz, Marcelo E.
author_facet Katz, Marcelo E.
Margulis, Fernando
Schiavelli, Rubén
Arias, Pablo
Head, Geoffrey A.
Golombek, Diego Andres
author_role author
author2 Margulis, Fernando
Schiavelli, Rubén
Arias, Pablo
Head, Geoffrey A.
Golombek, Diego Andres
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv AMBULATORY BLOOD PRESSURE MONITORING
COSINOR
DAILY RHYTHM
KIDNEY TRANSPLANTATION
NON-SYMMETRICAL DOUBLE-LOGISTIC ANALYSIS
topic AMBULATORY BLOOD PRESSURE MONITORING
COSINOR
DAILY RHYTHM
KIDNEY TRANSPLANTATION
NON-SYMMETRICAL DOUBLE-LOGISTIC ANALYSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Patients with kidney replacement exhibit disrupted circadian rhythms. Most studies measuring blood pressure use the dipper/non-dipper classification, which does not consider analysis of transitional stages between low and high blood pressure, confidence intervals nor shifts in the time of peak, while assuming subjective onsets of night and day phases. In order to better understand the nature of daily variation of blood pressure in these patients, we analyzed 24 h recordings from 41 renal transplant recipients using the non-symmetrical double-logistic fitting assessment which does not assume abruptness nor symmetry in ascending and descending stages of the blood pressure profile, and a cosine best-fitting regression method (Cosinor). Compared with matched controls, double-logistic fitting showed that the times for most transitional stages (ascending systolic and descending systolic, diastolic, and mean arterial pressure) had a wider distribution along the 24-h. The proportion of individuals without daily blood pressure rhythm in the transplanted group was larger only for systolic arterial pressure, and the amplitude showed no significant difference. Furthermore, the transplant recipient group had a less pronounced slope in descending systolic and ascending mean blood pressure. Cosinor analysis confirmed this phase-related changes, showing a wider distribution of times of peak (acrophases). We conclude that daily disruptions in renal transplant recipients can be explained not necessarily by an absence in diurnal variation, but also by changes in waveform-related parameters of the rhythm, and that alterations in the phase of the rhythm are the most consistent finding in these patients.
Fil: Katz, Marcelo E.. Universidad Nacional de Quilmes; Argentina
Fil: Margulis, Fernando. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina
Fil: Schiavelli, Rubén. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Cosme Argerich; Argentina
Fil: Arias, Pablo. Universidad de Buenos Aires; Argentina
Fil: Head, Geoffrey A.. No especifíca;
Fil: Golombek, Diego Andres. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Patients with kidney replacement exhibit disrupted circadian rhythms. Most studies measuring blood pressure use the dipper/non-dipper classification, which does not consider analysis of transitional stages between low and high blood pressure, confidence intervals nor shifts in the time of peak, while assuming subjective onsets of night and day phases. In order to better understand the nature of daily variation of blood pressure in these patients, we analyzed 24 h recordings from 41 renal transplant recipients using the non-symmetrical double-logistic fitting assessment which does not assume abruptness nor symmetry in ascending and descending stages of the blood pressure profile, and a cosine best-fitting regression method (Cosinor). Compared with matched controls, double-logistic fitting showed that the times for most transitional stages (ascending systolic and descending systolic, diastolic, and mean arterial pressure) had a wider distribution along the 24-h. The proportion of individuals without daily blood pressure rhythm in the transplanted group was larger only for systolic arterial pressure, and the amplitude showed no significant difference. Furthermore, the transplant recipient group had a less pronounced slope in descending systolic and ascending mean blood pressure. Cosinor analysis confirmed this phase-related changes, showing a wider distribution of times of peak (acrophases). We conclude that daily disruptions in renal transplant recipients can be explained not necessarily by an absence in diurnal variation, but also by changes in waveform-related parameters of the rhythm, and that alterations in the phase of the rhythm are the most consistent finding in these patients.
publishDate 2012
dc.date.none.fl_str_mv 2012-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/194719
Katz, Marcelo E.; Margulis, Fernando; Schiavelli, Rubén; Arias, Pablo; Head, Geoffrey A.; et al.; Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients; Frontiers Media; Frontiers in Neurology; 3; 3-2012; 35-43
1664-2295
CONICET Digital
CONICET
url http://hdl.handle.net/11336/194719
identifier_str_mv Katz, Marcelo E.; Margulis, Fernando; Schiavelli, Rubén; Arias, Pablo; Head, Geoffrey A.; et al.; Disruption of transitional stages in 24-h blood pressure recording in renal transplant recipients; Frontiers Media; Frontiers in Neurology; 3; 3-2012; 35-43
1664-2295
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fneur.2012.00035/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2012.00035
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083257394790400
score 13.22299

Publicaciones similares