Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis
- Autores
- Aguilera, Andrea Carolina; Carvelli, Flavia Lorena; Boschin, Veronica; Mohamed, Fabian Heber; Zyla, Leila Ester; Sosa Escudero, Miguel Angel
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- One of the most striking features of the mammalian epididymis is the secretion of lysosomal enzymes (LE). These LE may play a role in sperm maturation. In the present study we investigated the activity and distribution of four LE (b-galactosidase (b-Gal), N-acetyl-b-D-glucosaminidase (b-NAG), a-mannosidase (a-Man) and b-glucuronidase) in bull epididymis at two different ages (6 months and 4 years) to determine whether these enzymes vary with sexual 5 maturity. In young, sexually immature (SI) bulls we found high LE activity in the epididymal tissue that accounts for a developed and active lysosomal apparatus. In contrast, low LE activity was measured in sexually mature (SM) bulls, and b-NAG and b-Gal were mostly secreted into the lumen. We also attempted to correlate LE distribution with the expression and functionality of mannose-6-phosphate receptors (MPRs), which are thought to be involved in proper delivery of LE to lysosomes. The cation-dependent MPR was highly expressed in SI bulls, with expression decreasing during adulthood, 10 whereas the expression of the cation-independent MPR was higher in SM than SI bulls. In addition, the four enzymes recovered from the epididymal lumen interact with both MPRs at each age. We conclude that the activity and distribution of LE in bull epididymis varies with sexual maturity and that the distribution is regulated differently by the two types of MPR. These findings could provide some molecular basis for male infertility.
Fil: Aguilera, Andrea Carolina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Carvelli, Flavia Lorena. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Boschin, Veronica. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina
Fil: Mohamed, Fabian Heber. Universidad Nacional de San Luis; Argentina
Fil: Zyla, Leila Ester. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Sosa Escudero, Miguel Angel. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina - Materia
-
Epididymis
Lysosomal Enzymes
Mannose-6-Phosphate Receptors
Protein Secretion - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/41889
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Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymisAguilera, Andrea CarolinaCarvelli, Flavia LorenaBoschin, VeronicaMohamed, Fabian HeberZyla, Leila EsterSosa Escudero, Miguel AngelEpididymisLysosomal EnzymesMannose-6-Phosphate ReceptorsProtein Secretionhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1One of the most striking features of the mammalian epididymis is the secretion of lysosomal enzymes (LE). These LE may play a role in sperm maturation. In the present study we investigated the activity and distribution of four LE (b-galactosidase (b-Gal), N-acetyl-b-D-glucosaminidase (b-NAG), a-mannosidase (a-Man) and b-glucuronidase) in bull epididymis at two different ages (6 months and 4 years) to determine whether these enzymes vary with sexual 5 maturity. In young, sexually immature (SI) bulls we found high LE activity in the epididymal tissue that accounts for a developed and active lysosomal apparatus. In contrast, low LE activity was measured in sexually mature (SM) bulls, and b-NAG and b-Gal were mostly secreted into the lumen. We also attempted to correlate LE distribution with the expression and functionality of mannose-6-phosphate receptors (MPRs), which are thought to be involved in proper delivery of LE to lysosomes. The cation-dependent MPR was highly expressed in SI bulls, with expression decreasing during adulthood, 10 whereas the expression of the cation-independent MPR was higher in SM than SI bulls. In addition, the four enzymes recovered from the epididymal lumen interact with both MPRs at each age. We conclude that the activity and distribution of LE in bull epididymis varies with sexual maturity and that the distribution is regulated differently by the two types of MPR. These findings could provide some molecular basis for male infertility.Fil: Aguilera, Andrea Carolina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Carvelli, Flavia Lorena. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Boschin, Veronica. Universidad del Aconcagua. Facultad de Ciencias Médicas; ArgentinaFil: Mohamed, Fabian Heber. Universidad Nacional de San Luis; ArgentinaFil: Zyla, Leila Ester. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Sosa Escudero, Miguel Angel. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaCsiro Publishing2015-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41889Aguilera, Andrea Carolina; Carvelli, Flavia Lorena; Boschin, Veronica; Mohamed, Fabian Heber; Zyla, Leila Ester; et al.; Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis; Csiro Publishing; Reproduction Fertility and Development; 28; 10; 4-2015; 1608-16171031-3613CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1071/RD14380info:eu-repo/semantics/altIdentifier/url/http://www.publish.csiro.au/rd/RD14380info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:28:58Zoai:ri.conicet.gov.ar:11336/41889instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:28:58.796CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis |
title |
Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis |
spellingShingle |
Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis Aguilera, Andrea Carolina Epididymis Lysosomal Enzymes Mannose-6-Phosphate Receptors Protein Secretion |
title_short |
Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis |
title_full |
Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis |
title_fullStr |
Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis |
title_full_unstemmed |
Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis |
title_sort |
Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis |
dc.creator.none.fl_str_mv |
Aguilera, Andrea Carolina Carvelli, Flavia Lorena Boschin, Veronica Mohamed, Fabian Heber Zyla, Leila Ester Sosa Escudero, Miguel Angel |
author |
Aguilera, Andrea Carolina |
author_facet |
Aguilera, Andrea Carolina Carvelli, Flavia Lorena Boschin, Veronica Mohamed, Fabian Heber Zyla, Leila Ester Sosa Escudero, Miguel Angel |
author_role |
author |
author2 |
Carvelli, Flavia Lorena Boschin, Veronica Mohamed, Fabian Heber Zyla, Leila Ester Sosa Escudero, Miguel Angel |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Epididymis Lysosomal Enzymes Mannose-6-Phosphate Receptors Protein Secretion |
topic |
Epididymis Lysosomal Enzymes Mannose-6-Phosphate Receptors Protein Secretion |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
One of the most striking features of the mammalian epididymis is the secretion of lysosomal enzymes (LE). These LE may play a role in sperm maturation. In the present study we investigated the activity and distribution of four LE (b-galactosidase (b-Gal), N-acetyl-b-D-glucosaminidase (b-NAG), a-mannosidase (a-Man) and b-glucuronidase) in bull epididymis at two different ages (6 months and 4 years) to determine whether these enzymes vary with sexual 5 maturity. In young, sexually immature (SI) bulls we found high LE activity in the epididymal tissue that accounts for a developed and active lysosomal apparatus. In contrast, low LE activity was measured in sexually mature (SM) bulls, and b-NAG and b-Gal were mostly secreted into the lumen. We also attempted to correlate LE distribution with the expression and functionality of mannose-6-phosphate receptors (MPRs), which are thought to be involved in proper delivery of LE to lysosomes. The cation-dependent MPR was highly expressed in SI bulls, with expression decreasing during adulthood, 10 whereas the expression of the cation-independent MPR was higher in SM than SI bulls. In addition, the four enzymes recovered from the epididymal lumen interact with both MPRs at each age. We conclude that the activity and distribution of LE in bull epididymis varies with sexual maturity and that the distribution is regulated differently by the two types of MPR. These findings could provide some molecular basis for male infertility. Fil: Aguilera, Andrea Carolina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Carvelli, Flavia Lorena. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Boschin, Veronica. Universidad del Aconcagua. Facultad de Ciencias Médicas; Argentina Fil: Mohamed, Fabian Heber. Universidad Nacional de San Luis; Argentina Fil: Zyla, Leila Ester. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Sosa Escudero, Miguel Angel. Facultad de Ciencias Médicas. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina |
description |
One of the most striking features of the mammalian epididymis is the secretion of lysosomal enzymes (LE). These LE may play a role in sperm maturation. In the present study we investigated the activity and distribution of four LE (b-galactosidase (b-Gal), N-acetyl-b-D-glucosaminidase (b-NAG), a-mannosidase (a-Man) and b-glucuronidase) in bull epididymis at two different ages (6 months and 4 years) to determine whether these enzymes vary with sexual 5 maturity. In young, sexually immature (SI) bulls we found high LE activity in the epididymal tissue that accounts for a developed and active lysosomal apparatus. In contrast, low LE activity was measured in sexually mature (SM) bulls, and b-NAG and b-Gal were mostly secreted into the lumen. We also attempted to correlate LE distribution with the expression and functionality of mannose-6-phosphate receptors (MPRs), which are thought to be involved in proper delivery of LE to lysosomes. The cation-dependent MPR was highly expressed in SI bulls, with expression decreasing during adulthood, 10 whereas the expression of the cation-independent MPR was higher in SM than SI bulls. In addition, the four enzymes recovered from the epididymal lumen interact with both MPRs at each age. We conclude that the activity and distribution of LE in bull epididymis varies with sexual maturity and that the distribution is regulated differently by the two types of MPR. These findings could provide some molecular basis for male infertility. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/41889 Aguilera, Andrea Carolina; Carvelli, Flavia Lorena; Boschin, Veronica; Mohamed, Fabian Heber; Zyla, Leila Ester; et al.; Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis; Csiro Publishing; Reproduction Fertility and Development; 28; 10; 4-2015; 1608-1617 1031-3613 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/41889 |
identifier_str_mv |
Aguilera, Andrea Carolina; Carvelli, Flavia Lorena; Boschin, Veronica; Mohamed, Fabian Heber; Zyla, Leila Ester; et al.; Changes in lysosomal enzymes and mannose-6-phosphate receptors related to sexual maturation in bull epididymis; Csiro Publishing; Reproduction Fertility and Development; 28; 10; 4-2015; 1608-1617 1031-3613 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1071/RD14380 info:eu-repo/semantics/altIdentifier/url/http://www.publish.csiro.au/rd/RD14380 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Csiro Publishing |
publisher.none.fl_str_mv |
Csiro Publishing |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614294546677760 |
score |
13.069144 |