Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury

Autores
Gordillo, Gabriel Jorge; Krpetic, Zeljka; Brust, Mathias
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine
adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical
model system to study biomembrane penetration by gold nanoparticles. The hydrogen redoxchemistry characteristic of ligand-stabilized gold nanoparticles in molecularly close contact with a mercury electrode is used as an indicator of membrane penetration. Results for water-dispersible gold nanoparticles of two different sizes are reported, and comparisons are made with the cellular uptake of the same preparations of nanoparticles by a common human fibroblast cell line. The experimental system described here can be used to study physicochemical aspects of membrane penetration in the absence of complex biological mechanisms, and it could also be a starting point for the development of a test bed for the toxicity of nanomaterials.
Fil: Gordillo, Gabriel Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Krpetic, Zeljka. University of Liverpool; Reino Unido
Fil: Brust, Mathias. University of Liverpool; Reino Unido
Materia
Gold Nanoparticles
Phospholipid Monolayer
Electrochemistry
Membrane Penetration
Nanotoxicology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/80445
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercuryGordillo, Gabriel JorgeKrpetic, ZeljkaBrust, MathiasGold NanoparticlesPhospholipid MonolayerElectrochemistryMembrane PenetrationNanotoxicologyhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine<br />adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical<br />model system to study biomembrane penetration by gold nanoparticles. The hydrogen redoxchemistry characteristic of ligand-stabilized gold nanoparticles in molecularly close contact with a mercury electrode is used as an indicator of membrane penetration. Results for water-dispersible gold nanoparticles of two different sizes are reported, and comparisons are made with the cellular uptake of the same preparations of nanoparticles by a common human fibroblast cell line. The experimental system described here can be used to study physicochemical aspects of membrane penetration in the absence of complex biological mechanisms, and it could also be a starting point for the development of a test bed for the toxicity of nanomaterials.Fil: Gordillo, Gabriel Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Krpetic, Zeljka. University of Liverpool; Reino UnidoFil: Brust, Mathias. University of Liverpool; Reino UnidoAmerican Chemical Society2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80445Gordillo, Gabriel Jorge; Krpetic, Zeljka; Brust, Mathias; Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury; American Chemical Society; ACS Nano; 8; 6; 6-2014; 6074-60801936-0851CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1021/nn501395einfo:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/nn501395einfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:28Zoai:ri.conicet.gov.ar:11336/80445instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:28.943CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
title Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
spellingShingle Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
Gordillo, Gabriel Jorge
Gold Nanoparticles
Phospholipid Monolayer
Electrochemistry
Membrane Penetration
Nanotoxicology
title_short Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
title_full Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
title_fullStr Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
title_full_unstemmed Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
title_sort Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury
dc.creator.none.fl_str_mv Gordillo, Gabriel Jorge
Krpetic, Zeljka
Brust, Mathias
author Gordillo, Gabriel Jorge
author_facet Gordillo, Gabriel Jorge
Krpetic, Zeljka
Brust, Mathias
author_role author
author2 Krpetic, Zeljka
Brust, Mathias
author2_role author
author
dc.subject.none.fl_str_mv Gold Nanoparticles
Phospholipid Monolayer
Electrochemistry
Membrane Penetration
Nanotoxicology
topic Gold Nanoparticles
Phospholipid Monolayer
Electrochemistry
Membrane Penetration
Nanotoxicology
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine<br />adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical<br />model system to study biomembrane penetration by gold nanoparticles. The hydrogen redoxchemistry characteristic of ligand-stabilized gold nanoparticles in molecularly close contact with a mercury electrode is used as an indicator of membrane penetration. Results for water-dispersible gold nanoparticles of two different sizes are reported, and comparisons are made with the cellular uptake of the same preparations of nanoparticles by a common human fibroblast cell line. The experimental system described here can be used to study physicochemical aspects of membrane penetration in the absence of complex biological mechanisms, and it could also be a starting point for the development of a test bed for the toxicity of nanomaterials.
Fil: Gordillo, Gabriel Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentina
Fil: Krpetic, Zeljka. University of Liverpool; Reino Unido
Fil: Brust, Mathias. University of Liverpool; Reino Unido
description It is demonstrated that a compact monolayer of 1,2-dioleoyl-sn-glycero-3-phosphocholine<br />adsorbed to a hanging mercury drop electrode can serve as a simple electrochemical<br />model system to study biomembrane penetration by gold nanoparticles. The hydrogen redoxchemistry characteristic of ligand-stabilized gold nanoparticles in molecularly close contact with a mercury electrode is used as an indicator of membrane penetration. Results for water-dispersible gold nanoparticles of two different sizes are reported, and comparisons are made with the cellular uptake of the same preparations of nanoparticles by a common human fibroblast cell line. The experimental system described here can be used to study physicochemical aspects of membrane penetration in the absence of complex biological mechanisms, and it could also be a starting point for the development of a test bed for the toxicity of nanomaterials.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/80445
Gordillo, Gabriel Jorge; Krpetic, Zeljka; Brust, Mathias; Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury; American Chemical Society; ACS Nano; 8; 6; 6-2014; 6074-6080
1936-0851
CONICET Digital
CONICET
url http://hdl.handle.net/11336/80445
identifier_str_mv Gordillo, Gabriel Jorge; Krpetic, Zeljka; Brust, Mathias; Interactions of gold nanoparticles with a phospholipid monolayer membrane on mercury; American Chemical Society; ACS Nano; 8; 6; 6-2014; 6074-6080
1936-0851
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1021/nn501395e
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/nn501395e
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268797466050560
score 13.13397

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