Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment

Autores
Rodriguez, Yamila Isabel; Campos, Ludmila Estefanía; Castro, Melina Gabriela; Aladhami, Ahmed; Oskeritzian, Carole A.; Alvarez, Sergio Eduardo
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the last 15 years, increasing evidences demonstrate a strong link between sphingosine-1-phosphate (S1P) and both normal physiology and progression of different diseases, including cancer and inflammation. Indeed, numerous studies show that tissue levels of this sphingolipid metabolite are augmented in many cancers, affecting survival, proliferation, angiogenesis, and metastatic spread. Recent insights into the possible role of S1P as a therapeutic target has attracted enormous attention and opened new opportunities in this evolving field. In this review, we will focus on the role of S1P in cancer, with particular emphasis in new developments that highlight the many functions of this sphingolipid in the tumor microenvironment. We will discuss how S1P modulates phenotypic plasticity of macrophages and mast cells, tumor-induced immune evasion, differentiation and survival of immune cells in the tumor milieu, interaction between cancer and stromal cells, and hypoxic response.
Fil: Rodriguez, Yamila Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Campos, Ludmila Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Castro, Melina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Aladhami, Ahmed. University Of South Carolina School Of Medicine; Estados Unidos
Fil: Oskeritzian, Carole A.. University Of South Carolina School Of Medicine; Estados Unidos
Fil: Alvarez, Sergio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Materia
SPHINGOSINE-1-PHOSPHATE
TUMOR
MICROENVIRONMENT
INFLAMMATION
METASTASIS
MACROPHAGE POLARIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/126427
Acceder
id CONICETDig_880637b9633838476dea6f7f4614cba9
oai_identifier_str oai:ri.conicet.gov.ar:11336/126427
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironmentRodriguez, Yamila IsabelCampos, Ludmila EstefaníaCastro, Melina GabrielaAladhami, AhmedOskeritzian, Carole A.Alvarez, Sergio EduardoSPHINGOSINE-1-PHOSPHATETUMORMICROENVIRONMENTINFLAMMATIONMETASTASISMACROPHAGE POLARIZATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In the last 15 years, increasing evidences demonstrate a strong link between sphingosine-1-phosphate (S1P) and both normal physiology and progression of different diseases, including cancer and inflammation. Indeed, numerous studies show that tissue levels of this sphingolipid metabolite are augmented in many cancers, affecting survival, proliferation, angiogenesis, and metastatic spread. Recent insights into the possible role of S1P as a therapeutic target has attracted enormous attention and opened new opportunities in this evolving field. In this review, we will focus on the role of S1P in cancer, with particular emphasis in new developments that highlight the many functions of this sphingolipid in the tumor microenvironment. We will discuss how S1P modulates phenotypic plasticity of macrophages and mast cells, tumor-induced immune evasion, differentiation and survival of immune cells in the tumor milieu, interaction between cancer and stromal cells, and hypoxic response.Fil: Rodriguez, Yamila Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Campos, Ludmila Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Castro, Melina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Aladhami, Ahmed. University Of South Carolina School Of Medicine; Estados UnidosFil: Oskeritzian, Carole A.. University Of South Carolina School Of Medicine; Estados UnidosFil: Alvarez, Sergio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFrontiers Media S.A.2016-10-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/126427Rodriguez, Yamila Isabel; Campos, Ludmila Estefanía; Castro, Melina Gabriela; Aladhami, Ahmed; Oskeritzian, Carole A.; et al.; Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment; Frontiers Media S.A.; Frontiers in Oncology; 6; 218; 17-10-2016; 1-162234-943XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fonc.2016.00218/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2016.00218info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066089/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:17:10Zoai:ri.conicet.gov.ar:11336/126427instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:17:10.313CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
title Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
spellingShingle Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
Rodriguez, Yamila Isabel
SPHINGOSINE-1-PHOSPHATE
TUMOR
MICROENVIRONMENT
INFLAMMATION
METASTASIS
MACROPHAGE POLARIZATION
title_short Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
title_full Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
title_fullStr Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
title_full_unstemmed Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
title_sort Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment
dc.creator.none.fl_str_mv Rodriguez, Yamila Isabel
Campos, Ludmila Estefanía
Castro, Melina Gabriela
Aladhami, Ahmed
Oskeritzian, Carole A.
Alvarez, Sergio Eduardo
author Rodriguez, Yamila Isabel
author_facet Rodriguez, Yamila Isabel
Campos, Ludmila Estefanía
Castro, Melina Gabriela
Aladhami, Ahmed
Oskeritzian, Carole A.
Alvarez, Sergio Eduardo
author_role author
author2 Campos, Ludmila Estefanía
Castro, Melina Gabriela
Aladhami, Ahmed
Oskeritzian, Carole A.
Alvarez, Sergio Eduardo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv SPHINGOSINE-1-PHOSPHATE
TUMOR
MICROENVIRONMENT
INFLAMMATION
METASTASIS
MACROPHAGE POLARIZATION
topic SPHINGOSINE-1-PHOSPHATE
TUMOR
MICROENVIRONMENT
INFLAMMATION
METASTASIS
MACROPHAGE POLARIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In the last 15 years, increasing evidences demonstrate a strong link between sphingosine-1-phosphate (S1P) and both normal physiology and progression of different diseases, including cancer and inflammation. Indeed, numerous studies show that tissue levels of this sphingolipid metabolite are augmented in many cancers, affecting survival, proliferation, angiogenesis, and metastatic spread. Recent insights into the possible role of S1P as a therapeutic target has attracted enormous attention and opened new opportunities in this evolving field. In this review, we will focus on the role of S1P in cancer, with particular emphasis in new developments that highlight the many functions of this sphingolipid in the tumor microenvironment. We will discuss how S1P modulates phenotypic plasticity of macrophages and mast cells, tumor-induced immune evasion, differentiation and survival of immune cells in the tumor milieu, interaction between cancer and stromal cells, and hypoxic response.
Fil: Rodriguez, Yamila Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Campos, Ludmila Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Castro, Melina Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
Fil: Aladhami, Ahmed. University Of South Carolina School Of Medicine; Estados Unidos
Fil: Oskeritzian, Carole A.. University Of South Carolina School Of Medicine; Estados Unidos
Fil: Alvarez, Sergio Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
description In the last 15 years, increasing evidences demonstrate a strong link between sphingosine-1-phosphate (S1P) and both normal physiology and progression of different diseases, including cancer and inflammation. Indeed, numerous studies show that tissue levels of this sphingolipid metabolite are augmented in many cancers, affecting survival, proliferation, angiogenesis, and metastatic spread. Recent insights into the possible role of S1P as a therapeutic target has attracted enormous attention and opened new opportunities in this evolving field. In this review, we will focus on the role of S1P in cancer, with particular emphasis in new developments that highlight the many functions of this sphingolipid in the tumor microenvironment. We will discuss how S1P modulates phenotypic plasticity of macrophages and mast cells, tumor-induced immune evasion, differentiation and survival of immune cells in the tumor milieu, interaction between cancer and stromal cells, and hypoxic response.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-17
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/126427
Rodriguez, Yamila Isabel; Campos, Ludmila Estefanía; Castro, Melina Gabriela; Aladhami, Ahmed; Oskeritzian, Carole A.; et al.; Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment; Frontiers Media S.A.; Frontiers in Oncology; 6; 218; 17-10-2016; 1-16
2234-943X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/126427
identifier_str_mv Rodriguez, Yamila Isabel; Campos, Ludmila Estefanía; Castro, Melina Gabriela; Aladhami, Ahmed; Oskeritzian, Carole A.; et al.; Sphingosine-1 phosphate: A new modulator of immune plasticity in the tumor microenvironment; Frontiers Media S.A.; Frontiers in Oncology; 6; 218; 17-10-2016; 1-16
2234-943X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fonc.2016.00218/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2016.00218
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066089/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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