Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies

Autores
Rossi, Yanina Estefanía; Palacios, Sara Maria
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In a fumigant assay, Musca domestica adults treated with Eucalyptus cinerea EO [LC50 = 5.5 mg/dm3; majority component by SPME–GC: 1,8-cineole (88.5%), α-pinene (2%), α-terpineol (9%)], died within 15 min or less. The terpenes absorbed by the flies and their metabolites, analyzed using SPME fiber, were 1,8-cineole (LC50 = 3.3 mg/dm3), α-pinene (LC50 = 11.5 mg/dm3), α-terpineol (LC50 = 36.8 mg/dm3) and a new component 2,3-dehydro-1,8-cineole, in proportions of 74%, 0.1%, 24.7% and 1.2% respectively. 2,3-Dehydro-1,8-cineole and α-terpineol were formed by oxidation of 1,8-cineole mediated by cytochrome P450, as demonstrated by a fumigation assay on flies previously treated with piperonyl butoxide, a P450 inhibitor, which showed an increase in toxicity of the EO and 1,8-cineole, supporting its participation in the formation of metabolites. We also demonstrated that 1,8-cineole acts as a P450 inhibitor-like compound, improving the toxicity of other xenobiotics such as deltamethrin.
Fil: Rossi, Yanina Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Córdoba; Argentina
Fil: Palacios, Sara Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Córdoba; Argentina
Materia
Musca Domestica
Eucalyptus Cinerea
Essential Oil
1,8-Cineole
Cytochrome P450
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/33405
Acceder
id CONICETDig_87973b8fb54381a5b073afdf10248945
oai_identifier_str oai:ri.conicet.gov.ar:11336/33405
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of fliesRossi, Yanina EstefaníaPalacios, Sara MariaMusca DomesticaEucalyptus CinereaEssential Oil1,8-CineoleCytochrome P450https://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In a fumigant assay, Musca domestica adults treated with Eucalyptus cinerea EO [LC50 = 5.5 mg/dm3; majority component by SPME–GC: 1,8-cineole (88.5%), α-pinene (2%), α-terpineol (9%)], died within 15 min or less. The terpenes absorbed by the flies and their metabolites, analyzed using SPME fiber, were 1,8-cineole (LC50 = 3.3 mg/dm3), α-pinene (LC50 = 11.5 mg/dm3), α-terpineol (LC50 = 36.8 mg/dm3) and a new component 2,3-dehydro-1,8-cineole, in proportions of 74%, 0.1%, 24.7% and 1.2% respectively. 2,3-Dehydro-1,8-cineole and α-terpineol were formed by oxidation of 1,8-cineole mediated by cytochrome P450, as demonstrated by a fumigation assay on flies previously treated with piperonyl butoxide, a P450 inhibitor, which showed an increase in toxicity of the EO and 1,8-cineole, supporting its participation in the formation of metabolites. We also demonstrated that 1,8-cineole acts as a P450 inhibitor-like compound, improving the toxicity of other xenobiotics such as deltamethrin.Fil: Rossi, Yanina Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Córdoba; ArgentinaFil: Palacios, Sara Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Córdoba; ArgentinaElsevier Science2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/33405Rossi, Yanina Estefanía; Palacios, Sara Maria; Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies; Elsevier Science; Industrial Crops and Products; 63; 10-2014; 133-1370926-6690CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.indcrop.2014.10.019info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0926669014006256info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:29:46Zoai:ri.conicet.gov.ar:11336/33405instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:29:47.202CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies
title Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies
spellingShingle Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies
Rossi, Yanina Estefanía
Musca Domestica
Eucalyptus Cinerea
Essential Oil
1,8-Cineole
Cytochrome P450
title_short Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies
title_full Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies
title_fullStr Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies
title_full_unstemmed Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies
title_sort Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies
dc.creator.none.fl_str_mv Rossi, Yanina Estefanía
Palacios, Sara Maria
author Rossi, Yanina Estefanía
author_facet Rossi, Yanina Estefanía
Palacios, Sara Maria
author_role author
author2 Palacios, Sara Maria
author2_role author
dc.subject.none.fl_str_mv Musca Domestica
Eucalyptus Cinerea
Essential Oil
1,8-Cineole
Cytochrome P450
topic Musca Domestica
Eucalyptus Cinerea
Essential Oil
1,8-Cineole
Cytochrome P450
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In a fumigant assay, Musca domestica adults treated with Eucalyptus cinerea EO [LC50 = 5.5 mg/dm3; majority component by SPME–GC: 1,8-cineole (88.5%), α-pinene (2%), α-terpineol (9%)], died within 15 min or less. The terpenes absorbed by the flies and their metabolites, analyzed using SPME fiber, were 1,8-cineole (LC50 = 3.3 mg/dm3), α-pinene (LC50 = 11.5 mg/dm3), α-terpineol (LC50 = 36.8 mg/dm3) and a new component 2,3-dehydro-1,8-cineole, in proportions of 74%, 0.1%, 24.7% and 1.2% respectively. 2,3-Dehydro-1,8-cineole and α-terpineol were formed by oxidation of 1,8-cineole mediated by cytochrome P450, as demonstrated by a fumigation assay on flies previously treated with piperonyl butoxide, a P450 inhibitor, which showed an increase in toxicity of the EO and 1,8-cineole, supporting its participation in the formation of metabolites. We also demonstrated that 1,8-cineole acts as a P450 inhibitor-like compound, improving the toxicity of other xenobiotics such as deltamethrin.
Fil: Rossi, Yanina Estefanía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Córdoba; Argentina
Fil: Palacios, Sara Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Católica de Córdoba; Argentina
description In a fumigant assay, Musca domestica adults treated with Eucalyptus cinerea EO [LC50 = 5.5 mg/dm3; majority component by SPME–GC: 1,8-cineole (88.5%), α-pinene (2%), α-terpineol (9%)], died within 15 min or less. The terpenes absorbed by the flies and their metabolites, analyzed using SPME fiber, were 1,8-cineole (LC50 = 3.3 mg/dm3), α-pinene (LC50 = 11.5 mg/dm3), α-terpineol (LC50 = 36.8 mg/dm3) and a new component 2,3-dehydro-1,8-cineole, in proportions of 74%, 0.1%, 24.7% and 1.2% respectively. 2,3-Dehydro-1,8-cineole and α-terpineol were formed by oxidation of 1,8-cineole mediated by cytochrome P450, as demonstrated by a fumigation assay on flies previously treated with piperonyl butoxide, a P450 inhibitor, which showed an increase in toxicity of the EO and 1,8-cineole, supporting its participation in the formation of metabolites. We also demonstrated that 1,8-cineole acts as a P450 inhibitor-like compound, improving the toxicity of other xenobiotics such as deltamethrin.
publishDate 2014
dc.date.none.fl_str_mv 2014-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/33405
Rossi, Yanina Estefanía; Palacios, Sara Maria; Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies; Elsevier Science; Industrial Crops and Products; 63; 10-2014; 133-137
0926-6690
CONICET Digital
CONICET
url http://hdl.handle.net/11336/33405
identifier_str_mv Rossi, Yanina Estefanía; Palacios, Sara Maria; Insecticidal toxicity of Eucalyptus cinerea essential oil and 1,8-cineole against Musca domestica and possible uses according to the metabolic response of flies; Elsevier Science; Industrial Crops and Products; 63; 10-2014; 133-137
0926-6690
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.indcrop.2014.10.019
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0926669014006256
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082770896420864
score 13.22299

Publicaciones similares