Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats

Autores
Ragone, María Inés; Bayley, Matias; Lazarte, M. L.; Clavellino, L.; Prieto, J. J.; Ruiz, María Esperanza; Capone, E.; Consolini, A.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Drinking infusions of Melissa officinalis (Moff, “lemon balm”) or Bahuinia forficata (Baf, “cow´s hoof”) are clinically contraindicated in hypothyroidism (HypoT). However, it is not known whether they interfere in the cardiac response to coronary dysfunction. So, the aim of this work was to evaluate whether these plants interfere with the cardioprotection of HypoT after ischemia/reperfusion (I/R) in rats. In this model, HypoT was induced in rats by drinking methimazole for 15 days. Euthyroid (EuT) and HypoT rats drunk either Moff or Baf infusion during 7 days. Isolated perfused hearts were exposed to 20 min I/45min R inside a calorimeter, a model of stunning without infarct. Contractile pressure development (P, mmHg), diastolic pressure (LVEDP) and total heat rate (Ht, in mW/g) were measured. In EuT, Moff improved the postischemic contractile recovery (PICR) (105.0±16.4% of initial vs 69.4±6.0% in non-treated, p<0.05) and muscle economy (P/Ht). Baf slightly reduced PICR (40.4±6.7%) and significantly increased LVEDP. In HypoT hearts, Moff and Baf drastically reduced PICR (54.7±3.3% and 12.5±5.3% respectively vs 92.6±5.2% in non-treated, both p<0.05) as well as P/Ht, while increased LVEDP. Cyclosporine-A reversed the Moff dysfunction but not that of Baf, which was neither reduced by diazoxide. Results show that under HypoT Moff induced the opening of mPTP which reduce postischemic recovery, and Baf worsened the dysfunction although it was not related to mitochondrial calcium overload. Results suggest that the use of these plants in hypothyroid individuals with risk of cardiac ischemic episodes requires precaution.
Fil: Ragone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Bayley, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Lazarte, M. L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Clavellino, L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Prieto, J. J.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Control de Calidad de Medicamentos; Argentina
Fil: Ruiz, María Esperanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Control de Calidad de Medicamentos; Argentina
Fil: Capone, E.. Università Cattolica del Sacro Cuore; Italia
Fil: Consolini, A.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Materia
HEART
ISCHEMIA/REPERFUSION
STUNNING
HYPOTHYROIDISM
LEMON-BALM
COW'S HOOF
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130600
Acceder
id CONICETDig_874918d59f3641bc0589626c85b4c37c
oai_identifier_str oai:ri.conicet.gov.ar:11336/130600
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid ratsRagone, María InésBayley, MatiasLazarte, M. L.Clavellino, L.Prieto, J. J.Ruiz, María EsperanzaCapone, E.Consolini, A.HEARTISCHEMIA/REPERFUSIONSTUNNINGHYPOTHYROIDISMLEMON-BALMCOW'S HOOFhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Drinking infusions of Melissa officinalis (Moff, “lemon balm”) or Bahuinia forficata (Baf, “cow´s hoof”) are clinically contraindicated in hypothyroidism (HypoT). However, it is not known whether they interfere in the cardiac response to coronary dysfunction. So, the aim of this work was to evaluate whether these plants interfere with the cardioprotection of HypoT after ischemia/reperfusion (I/R) in rats. In this model, HypoT was induced in rats by drinking methimazole for 15 days. Euthyroid (EuT) and HypoT rats drunk either Moff or Baf infusion during 7 days. Isolated perfused hearts were exposed to 20 min I/45min R inside a calorimeter, a model of stunning without infarct. Contractile pressure development (P, mmHg), diastolic pressure (LVEDP) and total heat rate (Ht, in mW/g) were measured. In EuT, Moff improved the postischemic contractile recovery (PICR) (105.0±16.4% of initial vs 69.4±6.0% in non-treated, p<0.05) and muscle economy (P/Ht). Baf slightly reduced PICR (40.4±6.7%) and significantly increased LVEDP. In HypoT hearts, Moff and Baf drastically reduced PICR (54.7±3.3% and 12.5±5.3% respectively vs 92.6±5.2% in non-treated, both p<0.05) as well as P/Ht, while increased LVEDP. Cyclosporine-A reversed the Moff dysfunction but not that of Baf, which was neither reduced by diazoxide. Results show that under HypoT Moff induced the opening of mPTP which reduce postischemic recovery, and Baf worsened the dysfunction although it was not related to mitochondrial calcium overload. Results suggest that the use of these plants in hypothyroid individuals with risk of cardiac ischemic episodes requires precaution.Fil: Ragone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Bayley, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Lazarte, M. L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Clavellino, L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Prieto, J. J.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Control de Calidad de Medicamentos; ArgentinaFil: Ruiz, María Esperanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Control de Calidad de Medicamentos; ArgentinaFil: Capone, E.. Università Cattolica del Sacro Cuore; ItaliaFil: Consolini, A.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaSocietà Italo-Latinoamericana di Etnomedicina2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/130600Ragone, María Inés; Bayley, Matias; Lazarte, M. L.; Clavellino, L.; Prieto, J. J.; et al.; Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats; Società Italo-Latinoamericana di Etnomedicina; Pharmacology Online; 3; 12-2019; 1-141827-8620CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pharmacologyonline.silae.it/front/archives_2019_3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:45:21Zoai:ri.conicet.gov.ar:11336/130600instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:45:21.83CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats
title Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats
spellingShingle Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats
Ragone, María Inés
HEART
ISCHEMIA/REPERFUSION
STUNNING
HYPOTHYROIDISM
LEMON-BALM
COW'S HOOF
title_short Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats
title_full Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats
title_fullStr Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats
title_full_unstemmed Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats
title_sort Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats
dc.creator.none.fl_str_mv Ragone, María Inés
Bayley, Matias
Lazarte, M. L.
Clavellino, L.
Prieto, J. J.
Ruiz, María Esperanza
Capone, E.
Consolini, A.
author Ragone, María Inés
author_facet Ragone, María Inés
Bayley, Matias
Lazarte, M. L.
Clavellino, L.
Prieto, J. J.
Ruiz, María Esperanza
Capone, E.
Consolini, A.
author_role author
author2 Bayley, Matias
Lazarte, M. L.
Clavellino, L.
Prieto, J. J.
Ruiz, María Esperanza
Capone, E.
Consolini, A.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HEART
ISCHEMIA/REPERFUSION
STUNNING
HYPOTHYROIDISM
LEMON-BALM
COW'S HOOF
topic HEART
ISCHEMIA/REPERFUSION
STUNNING
HYPOTHYROIDISM
LEMON-BALM
COW'S HOOF
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Drinking infusions of Melissa officinalis (Moff, “lemon balm”) or Bahuinia forficata (Baf, “cow´s hoof”) are clinically contraindicated in hypothyroidism (HypoT). However, it is not known whether they interfere in the cardiac response to coronary dysfunction. So, the aim of this work was to evaluate whether these plants interfere with the cardioprotection of HypoT after ischemia/reperfusion (I/R) in rats. In this model, HypoT was induced in rats by drinking methimazole for 15 days. Euthyroid (EuT) and HypoT rats drunk either Moff or Baf infusion during 7 days. Isolated perfused hearts were exposed to 20 min I/45min R inside a calorimeter, a model of stunning without infarct. Contractile pressure development (P, mmHg), diastolic pressure (LVEDP) and total heat rate (Ht, in mW/g) were measured. In EuT, Moff improved the postischemic contractile recovery (PICR) (105.0±16.4% of initial vs 69.4±6.0% in non-treated, p<0.05) and muscle economy (P/Ht). Baf slightly reduced PICR (40.4±6.7%) and significantly increased LVEDP. In HypoT hearts, Moff and Baf drastically reduced PICR (54.7±3.3% and 12.5±5.3% respectively vs 92.6±5.2% in non-treated, both p<0.05) as well as P/Ht, while increased LVEDP. Cyclosporine-A reversed the Moff dysfunction but not that of Baf, which was neither reduced by diazoxide. Results show that under HypoT Moff induced the opening of mPTP which reduce postischemic recovery, and Baf worsened the dysfunction although it was not related to mitochondrial calcium overload. Results suggest that the use of these plants in hypothyroid individuals with risk of cardiac ischemic episodes requires precaution.
Fil: Ragone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Bayley, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Lazarte, M. L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Clavellino, L.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Prieto, J. J.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Control de Calidad de Medicamentos; Argentina
Fil: Ruiz, María Esperanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Control de Calidad de Medicamentos; Argentina
Fil: Capone, E.. Università Cattolica del Sacro Cuore; Italia
Fil: Consolini, A.. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
description Drinking infusions of Melissa officinalis (Moff, “lemon balm”) or Bahuinia forficata (Baf, “cow´s hoof”) are clinically contraindicated in hypothyroidism (HypoT). However, it is not known whether they interfere in the cardiac response to coronary dysfunction. So, the aim of this work was to evaluate whether these plants interfere with the cardioprotection of HypoT after ischemia/reperfusion (I/R) in rats. In this model, HypoT was induced in rats by drinking methimazole for 15 days. Euthyroid (EuT) and HypoT rats drunk either Moff or Baf infusion during 7 days. Isolated perfused hearts were exposed to 20 min I/45min R inside a calorimeter, a model of stunning without infarct. Contractile pressure development (P, mmHg), diastolic pressure (LVEDP) and total heat rate (Ht, in mW/g) were measured. In EuT, Moff improved the postischemic contractile recovery (PICR) (105.0±16.4% of initial vs 69.4±6.0% in non-treated, p<0.05) and muscle economy (P/Ht). Baf slightly reduced PICR (40.4±6.7%) and significantly increased LVEDP. In HypoT hearts, Moff and Baf drastically reduced PICR (54.7±3.3% and 12.5±5.3% respectively vs 92.6±5.2% in non-treated, both p<0.05) as well as P/Ht, while increased LVEDP. Cyclosporine-A reversed the Moff dysfunction but not that of Baf, which was neither reduced by diazoxide. Results show that under HypoT Moff induced the opening of mPTP which reduce postischemic recovery, and Baf worsened the dysfunction although it was not related to mitochondrial calcium overload. Results suggest that the use of these plants in hypothyroid individuals with risk of cardiac ischemic episodes requires precaution.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130600
Ragone, María Inés; Bayley, Matias; Lazarte, M. L.; Clavellino, L.; Prieto, J. J.; et al.; Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats; Società Italo-Latinoamericana di Etnomedicina; Pharmacology Online; 3; 12-2019; 1-14
1827-8620
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130600
identifier_str_mv Ragone, María Inés; Bayley, Matias; Lazarte, M. L.; Clavellino, L.; Prieto, J. J.; et al.; Oral administration of Melissa officinalis or Bahuinia forficata infusions reduce the postischemic recovery of hearts from hypothyroid rats; Società Italo-Latinoamericana di Etnomedicina; Pharmacology Online; 3; 12-2019; 1-14
1827-8620
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pharmacologyonline.silae.it/front/archives_2019_3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Società Italo-Latinoamericana di Etnomedicina
publisher.none.fl_str_mv Società Italo-Latinoamericana di Etnomedicina
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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