Distinction and mutual Influences between Parkinson's Disease‐related and unrelated Chronic Pain

• Autores: Hunger, Jonathan; Brugger, Florian; Kägi, Georg; Möller, Jens Carsten; Hollenstein, Nathalie; Benninger, David H.; Tinazzi, Michele; Bally, Julien F.; Gonzenbach, Roman; Ciampi de Andrade, Daniel; Perez Lloret, Santiago; Mylius, Veit
• Año de publicación: 2025
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Parkinson's disease; Pain
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Background: Background Chronic pain (i.e. > 3 months) is a common nonmotor symptom in patients with Parkinson’s disease (PD), but the attribution to PD is critical for further treatment. Objectives: Objectives We explored the PD Pain Classification System (PD-PCS) criteria for the diagnosis of PD-related pain and mutual influences between PD-related and PD-unrelated pain. Methods: Methods In this multicenter study, 120 nondemented PD patients were assessed using the PD-PCS as well as motor and nonmotor questionnaires. The PD-PCS consists of 3 steps: first, it classifies chronic pain as unrelated or related to PD according to 1 of 4 criteria (at onset or aggravated by PD, in the off phase, improvement with dopaminergic treatment, and with dyskinesia); second, it allows the classification of pain mechanisms (neuropathic, nociceptive, and nociplastic); and finally, it provides a score. Results: Results Chronic pain was present in 92% of patients, with PD-related pain in 73% and non-PD-related pain in 53%. Higher PD-PCS scores were reported when PD-related pain was present. In cases of concurrent PD-related and PD-unrelated pain (35%), there was a moderate correlation between pain severity. Improvement with dopaminergic medication and pain in the off phases were the most common factors defining an association of pain with PD. These factors often occur together, whereas pain during dyskinesia occurs independently. Conclusion: Conclusion The PD-PCS criteria allow differentiation between PD-related and PD-unrelated chronic pain through 2 approaches, assessing periods of either low or high dopaminergic stimulation. PD-unrelated pain should also be taken into account, as it is more common than in the general population and as it may influence PD-related pain.
Fil: Hunger, Jonathan. Center for Neurorehabilitation; Suiza
Fil: Brugger, Florian. Kantonsspital; Suiza
Fil: Kägi, Georg. Kantonsspital; Suiza. University of Bern; Suiza
Fil: Möller, Jens Carsten. Philipps University; Alemania. Center for Neurorehabilitation; Suiza. HFR Meyriez-Murten; Suiza. HFR Fribourg–Cantonal Hospital; Suiza
Fil: Hollenstein, Nathalie. Center for Neurorehabilitation; Suiza
Fil: Benninger, David H.. Center for Parkinson and Movement Disorders; Suiza. Universite de Lausanne; Suiza. Universidad de Basilea; Suiza
Fil: Tinazzi, Michele. Universita di Verona; Italia
Fil: Bally, Julien F.. Universite de Lausanne; Suiza
Fil: Gonzenbach, Roman. Center for Neurorehabilitation; Suiza
Fil: Ciampi de Andrade, Daniel. Aalborg University; Dinamarca
Fil: Perez Lloret, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Pontificia Universidad Catolica Argentina "Santa Maria de los Buenos Aires". Vicerrectorado de Investigacion e Innovacion Academica. Laboratorio de Investigacion en Ciencias de Datos;
Fil: Mylius, Veit. Center for Neurorehabilitation; Suiza. Philipps University; Alemania. Kantonsspital Graubünden; Suiza