Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons

Autores
Amarillo Gomez, Yimy; Mato, German; Nadal, Marcela
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Thalamocortical neurons are involved in the generation and maintenance of brain rhythms associated with global functional states. The repetitive burst firing of TC neurons at delta frequencies (1-4 Hz) has been linked to the oscillations recorded during deep sleep and during episodes of absence seizures. To get insight into the biophysical properties that are the basis for intrinsic delta oscillations in these neurons, we performed a bifurcation analysis of a minimal conductance-based thalamocortical neuron model including only the IT channel and the sodium and potassium leak channels. This analysis unveils the dynamics of repetitive burst firing of TC neurons, and describes how the interplay between the amplifying variable mT and the recovering variable hT of the calcium channel IT is sufficient to generate low threshold oscillations in the delta band. We also explored the role of the hyperpolarization activated cationic current Ih in this reduced model and determine that, albeit not required, Ih amplifies and stabilizes the oscillation.
Fil: Amarillo Gomez, Yimy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Mato, German. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina
Fil: Nadal, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Materia
T-TYPE CALCIUM CHANNEL
THALAMOCORTICAL NEURONS
REPETITIVE BURST FIRING
SUB-THRESHOLD CONDUCTANCES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/46064
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neuronsAmarillo Gomez, YimyMato, GermanNadal, MarcelaT-TYPE CALCIUM CHANNELTHALAMOCORTICAL NEURONSREPETITIVE BURST FIRINGSUB-THRESHOLD CONDUCTANCEShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Thalamocortical neurons are involved in the generation and maintenance of brain rhythms associated with global functional states. The repetitive burst firing of TC neurons at delta frequencies (1-4 Hz) has been linked to the oscillations recorded during deep sleep and during episodes of absence seizures. To get insight into the biophysical properties that are the basis for intrinsic delta oscillations in these neurons, we performed a bifurcation analysis of a minimal conductance-based thalamocortical neuron model including only the IT channel and the sodium and potassium leak channels. This analysis unveils the dynamics of repetitive burst firing of TC neurons, and describes how the interplay between the amplifying variable mT and the recovering variable hT of the calcium channel IT is sufficient to generate low threshold oscillations in the delta band. We also explored the role of the hyperpolarization activated cationic current Ih in this reduced model and determine that, albeit not required, Ih amplifies and stabilizes the oscillation.Fil: Amarillo Gomez, Yimy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Mato, German. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; ArgentinaFil: Nadal, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFrontiers Research Foundation2015-05-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/46064Amarillo Gomez, Yimy; Mato, German; Nadal, Marcela; Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons; Frontiers Research Foundation; Frontiers in Computational Neuroscience; 9; 52; 7-5-2015; 1-91662-5188CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fncom.2015.00052/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fncom.2015.00052info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:26Zoai:ri.conicet.gov.ar:11336/46064instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:27.094CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
title Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
spellingShingle Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
Amarillo Gomez, Yimy
T-TYPE CALCIUM CHANNEL
THALAMOCORTICAL NEURONS
REPETITIVE BURST FIRING
SUB-THRESHOLD CONDUCTANCES
title_short Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
title_full Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
title_fullStr Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
title_full_unstemmed Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
title_sort Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
dc.creator.none.fl_str_mv Amarillo Gomez, Yimy
Mato, German
Nadal, Marcela
author Amarillo Gomez, Yimy
author_facet Amarillo Gomez, Yimy
Mato, German
Nadal, Marcela
author_role author
author2 Mato, German
Nadal, Marcela
author2_role author
author
dc.subject.none.fl_str_mv T-TYPE CALCIUM CHANNEL
THALAMOCORTICAL NEURONS
REPETITIVE BURST FIRING
SUB-THRESHOLD CONDUCTANCES
topic T-TYPE CALCIUM CHANNEL
THALAMOCORTICAL NEURONS
REPETITIVE BURST FIRING
SUB-THRESHOLD CONDUCTANCES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Thalamocortical neurons are involved in the generation and maintenance of brain rhythms associated with global functional states. The repetitive burst firing of TC neurons at delta frequencies (1-4 Hz) has been linked to the oscillations recorded during deep sleep and during episodes of absence seizures. To get insight into the biophysical properties that are the basis for intrinsic delta oscillations in these neurons, we performed a bifurcation analysis of a minimal conductance-based thalamocortical neuron model including only the IT channel and the sodium and potassium leak channels. This analysis unveils the dynamics of repetitive burst firing of TC neurons, and describes how the interplay between the amplifying variable mT and the recovering variable hT of the calcium channel IT is sufficient to generate low threshold oscillations in the delta band. We also explored the role of the hyperpolarization activated cationic current Ih in this reduced model and determine that, albeit not required, Ih amplifies and stabilizes the oscillation.
Fil: Amarillo Gomez, Yimy. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Mato, German. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina
Fil: Nadal, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
description Thalamocortical neurons are involved in the generation and maintenance of brain rhythms associated with global functional states. The repetitive burst firing of TC neurons at delta frequencies (1-4 Hz) has been linked to the oscillations recorded during deep sleep and during episodes of absence seizures. To get insight into the biophysical properties that are the basis for intrinsic delta oscillations in these neurons, we performed a bifurcation analysis of a minimal conductance-based thalamocortical neuron model including only the IT channel and the sodium and potassium leak channels. This analysis unveils the dynamics of repetitive burst firing of TC neurons, and describes how the interplay between the amplifying variable mT and the recovering variable hT of the calcium channel IT is sufficient to generate low threshold oscillations in the delta band. We also explored the role of the hyperpolarization activated cationic current Ih in this reduced model and determine that, albeit not required, Ih amplifies and stabilizes the oscillation.
publishDate 2015
dc.date.none.fl_str_mv 2015-05-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/46064
Amarillo Gomez, Yimy; Mato, German; Nadal, Marcela; Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons; Frontiers Research Foundation; Frontiers in Computational Neuroscience; 9; 52; 7-5-2015; 1-9
1662-5188
CONICET Digital
CONICET
url http://hdl.handle.net/11336/46064
identifier_str_mv Amarillo Gomez, Yimy; Mato, German; Nadal, Marcela; Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons; Frontiers Research Foundation; Frontiers in Computational Neuroscience; 9; 52; 7-5-2015; 1-9
1662-5188
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://journal.frontiersin.org/article/10.3389/fncom.2015.00052/abstract
info:eu-repo/semantics/altIdentifier/doi/10.3389/fncom.2015.00052
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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