Fatal canine encephalitozoonosis in Latin America, first report

Autores
Postma, Gabriela Cintia; Pardini, Lais Luján; Carnevale, Silvana; Gregnoli, Elena; Quiroga, María Alejandra; Venturini, María Cecilia; Minatel, Leonardo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Encephalitozoon cuniculi is an obligate, intracellular microsporidian organism capable of establish infection in a wide variety of animals. In carnivores it may cause a sporadic, severe disease in the first few months of life, which usually culminates with the death of the animal. The objective of this study was to report a natural fatal case of encephalitozoonosis in a puppy from Argentina. Clinical signs included reduced appetite, depression, vocalizing, weight loss, weakness, convulsions and recumbency. No significant gross lesions were noticed at necropsy. Microscopically, severe, diffuse, lymphocytic encephalitis was seen. Large cytoplasmic vacuoles containing spores, morphologically compatible with E. cuniculi, were present within endothelial cells of brain and kidney, in renal tubular epithelium and hepatocytes. Encephalitozoon cuniculi DNA was detected by PCR in the kidney. Antibody titers to E. cuniculi in serum from the surviving puppies and the dam were ≥ 1:200. This report contributes to our understanding of neurologic disease in puppies. Encephalitozoonosis should be considered as a differential diagnosis in cases of fatal encephalitis in puppies.
Fil: Postma, Gabriela Cintia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Pardini, Lais Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina
Fil: Carnevale, Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Gregnoli, Elena. No especifica;
Fil: Quiroga, María Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
Fil: Venturini, María Cecilia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina
Fil: Minatel, Leonardo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Materia
CANINE
ENCEPHALITIS
ENCEPHALITOZOON CUNICULI
NEPHRITIS
PUPPY
Nivel de accesibilidad
acceso embargado
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/57480
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fatal canine encephalitozoonosis in Latin America, first reportPostma, Gabriela CintiaPardini, Lais LujánCarnevale, SilvanaGregnoli, ElenaQuiroga, María AlejandraVenturini, María CeciliaMinatel, LeonardoCANINEENCEPHALITISENCEPHALITOZOON CUNICULINEPHRITISPUPPYhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Encephalitozoon cuniculi is an obligate, intracellular microsporidian organism capable of establish infection in a wide variety of animals. In carnivores it may cause a sporadic, severe disease in the first few months of life, which usually culminates with the death of the animal. The objective of this study was to report a natural fatal case of encephalitozoonosis in a puppy from Argentina. Clinical signs included reduced appetite, depression, vocalizing, weight loss, weakness, convulsions and recumbency. No significant gross lesions were noticed at necropsy. Microscopically, severe, diffuse, lymphocytic encephalitis was seen. Large cytoplasmic vacuoles containing spores, morphologically compatible with E. cuniculi, were present within endothelial cells of brain and kidney, in renal tubular epithelium and hepatocytes. Encephalitozoon cuniculi DNA was detected by PCR in the kidney. Antibody titers to E. cuniculi in serum from the surviving puppies and the dam were ≥ 1:200. This report contributes to our understanding of neurologic disease in puppies. Encephalitozoonosis should be considered as a differential diagnosis in cases of fatal encephalitis in puppies.Fil: Postma, Gabriela Cintia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Pardini, Lais Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; ArgentinaFil: Carnevale, Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; ArgentinaFil: Gregnoli, Elena. No especifica;Fil: Quiroga, María Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; ArgentinaFil: Venturini, María Cecilia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; ArgentinaFil: Minatel, Leonardo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaElsevier2018-01info:eu-repo/date/embargoEnd/2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/57480Postma, Gabriela Cintia; Pardini, Lais Luján; Carnevale, Silvana; Gregnoli, Elena; Quiroga, María Alejandra; et al.; Fatal canine encephalitozoonosis in Latin America, first report; Elsevier; Veterinary Parasitology: Regional Studies and Reports; 11; 1-2018; 15-182405-9390CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2405939017301326info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vprsr.2017.11.007info:eu-repo/semantics/embargoedAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-05-27T14:31:47Zoai:ri.conicet.gov.ar:11336/57480instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-05-27 14:31:47.68CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fatal canine encephalitozoonosis in Latin America, first report
title Fatal canine encephalitozoonosis in Latin America, first report
spellingShingle Fatal canine encephalitozoonosis in Latin America, first report
Postma, Gabriela Cintia
CANINE
ENCEPHALITIS
ENCEPHALITOZOON CUNICULI
NEPHRITIS
PUPPY
title_short Fatal canine encephalitozoonosis in Latin America, first report
title_full Fatal canine encephalitozoonosis in Latin America, first report
title_fullStr Fatal canine encephalitozoonosis in Latin America, first report
title_full_unstemmed Fatal canine encephalitozoonosis in Latin America, first report
title_sort Fatal canine encephalitozoonosis in Latin America, first report
dc.creator.none.fl_str_mv Postma, Gabriela Cintia
Pardini, Lais Luján
Carnevale, Silvana
Gregnoli, Elena
Quiroga, María Alejandra
Venturini, María Cecilia
Minatel, Leonardo
author Postma, Gabriela Cintia
author_facet Postma, Gabriela Cintia
Pardini, Lais Luján
Carnevale, Silvana
Gregnoli, Elena
Quiroga, María Alejandra
Venturini, María Cecilia
Minatel, Leonardo
author_role author
author2 Pardini, Lais Luján
Carnevale, Silvana
Gregnoli, Elena
Quiroga, María Alejandra
Venturini, María Cecilia
Minatel, Leonardo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CANINE
ENCEPHALITIS
ENCEPHALITOZOON CUNICULI
NEPHRITIS
PUPPY
topic CANINE
ENCEPHALITIS
ENCEPHALITOZOON CUNICULI
NEPHRITIS
PUPPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Encephalitozoon cuniculi is an obligate, intracellular microsporidian organism capable of establish infection in a wide variety of animals. In carnivores it may cause a sporadic, severe disease in the first few months of life, which usually culminates with the death of the animal. The objective of this study was to report a natural fatal case of encephalitozoonosis in a puppy from Argentina. Clinical signs included reduced appetite, depression, vocalizing, weight loss, weakness, convulsions and recumbency. No significant gross lesions were noticed at necropsy. Microscopically, severe, diffuse, lymphocytic encephalitis was seen. Large cytoplasmic vacuoles containing spores, morphologically compatible with E. cuniculi, were present within endothelial cells of brain and kidney, in renal tubular epithelium and hepatocytes. Encephalitozoon cuniculi DNA was detected by PCR in the kidney. Antibody titers to E. cuniculi in serum from the surviving puppies and the dam were ≥ 1:200. This report contributes to our understanding of neurologic disease in puppies. Encephalitozoonosis should be considered as a differential diagnosis in cases of fatal encephalitis in puppies.
Fil: Postma, Gabriela Cintia. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Pardini, Lais Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina
Fil: Carnevale, Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud ; Argentina
Fil: Gregnoli, Elena. No especifica;
Fil: Quiroga, María Alejandra. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
Fil: Venturini, María Cecilia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina
Fil: Minatel, Leonardo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
description Encephalitozoon cuniculi is an obligate, intracellular microsporidian organism capable of establish infection in a wide variety of animals. In carnivores it may cause a sporadic, severe disease in the first few months of life, which usually culminates with the death of the animal. The objective of this study was to report a natural fatal case of encephalitozoonosis in a puppy from Argentina. Clinical signs included reduced appetite, depression, vocalizing, weight loss, weakness, convulsions and recumbency. No significant gross lesions were noticed at necropsy. Microscopically, severe, diffuse, lymphocytic encephalitis was seen. Large cytoplasmic vacuoles containing spores, morphologically compatible with E. cuniculi, were present within endothelial cells of brain and kidney, in renal tubular epithelium and hepatocytes. Encephalitozoon cuniculi DNA was detected by PCR in the kidney. Antibody titers to E. cuniculi in serum from the surviving puppies and the dam were ≥ 1:200. This report contributes to our understanding of neurologic disease in puppies. Encephalitozoonosis should be considered as a differential diagnosis in cases of fatal encephalitis in puppies.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
info:eu-repo/date/embargoEnd/2019-02-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/57480
Postma, Gabriela Cintia; Pardini, Lais Luján; Carnevale, Silvana; Gregnoli, Elena; Quiroga, María Alejandra; et al.; Fatal canine encephalitozoonosis in Latin America, first report; Elsevier; Veterinary Parasitology: Regional Studies and Reports; 11; 1-2018; 15-18
2405-9390
CONICET Digital
CONICET
url http://hdl.handle.net/11336/57480
identifier_str_mv Postma, Gabriela Cintia; Pardini, Lais Luján; Carnevale, Silvana; Gregnoli, Elena; Quiroga, María Alejandra; et al.; Fatal canine encephalitozoonosis in Latin America, first report; Elsevier; Veterinary Parasitology: Regional Studies and Reports; 11; 1-2018; 15-18
2405-9390
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2405939017301326
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.vprsr.2017.11.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv embargoedAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.143419

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