Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective i...

Autores
Castro, Maximiliano Gabriel; Argarañá, María Fernanda; Bernasconi, Carla; Margenet, Leticia Elena; Amato, Ana Paula; Coduri Anthonioz Blanc, Joaquín Ignacio; Rottoli, Erwin Alexander; Protto Baglione, Manuel; Vicino, Macarena; Sadonio, María José; Galluccio, Federico Rafael; Musacchio, Héctor Mario; Pasteran, Fernando; Gómez, Sonia Alejandra
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: The spread of carbapenemase-producing bacteria (CPB) isexacerbated in hospital settings, making the surveillance of rectal carriage ofCPB crucial to halt their spread. However, the processing time until detectionwith traditional methods and the cost of new techniques limit theirimplementation. We aimed to evaluate the effectiveness of infectionprevention and control (IPC) measures guided by a novel algorithm (NA) forrectal swab processing, which incorporated a modified Blue-Carba test (mBCT),in reducing carbapenemase-producing bacteria (CPB) rectal carriage prevalencein general wards of a tertiary-care hospital from Argentina. Additionally, weassessed the impact of this algorithm on microbiological turnaround time(mTAT) and time to positive results (TPR).Materials and methods: An experimental and quasi-experimental designs werecombined into a prospective interrupted time series study structured in threephases: P1 (February 2022-July 2022), P2 (August 2022-January 2023;intervention) and P3 (February 2023-July 2023). Briefly, the NA included askey steps a 6-hour pre-incubation at 37 °C in nutrient broth, followed by a15-minute centrifugation at 3,200 rpm. The mBCT was set at pH 10.7 using 9 mgof imipenem in a final volume of 150 μL and was validated against conventionalmethods testing 1,120 samples. It was subsequently implemented to assess itsimpact on hospital CPB prevalence and the effectiveness of IPC measures. Patientswere randomly selected for CPB rectal screening during Phases 1 and 3 andprovided informed consent for inclusion.Results: The mBCT significantly shortened the mTAT and TPR compared tostandard approaches (<24 h vs. 4d, p < 0.001), showing moderate sensitivity[54.6% (IC95% 45.2–63.7)] and high specificity [99.8% (IC 95% 99.3–100)]. TheIPC intervention guided by the mBCT reduced CPB prevalence in general wards(8.1% vs. 13.8%, p = 0.006).Conclusion: The implementation of the NA reduced mTAT with high sensitivity,while the mBCT also contributed to reducing TPR with high specificity. Integratingthe NA and mBCT into IPC protocols led to a decrease in CPB rectal carriageprevalence in general wards, underscoring their diagnostic, epidemiological andthus IPC benefits.
Fil: Castro, Maximiliano Gabriel. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Médicas; Argentina
Fil: Argarañá, María Fernanda. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Bernasconi, Carla. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Margenet, Leticia Elena. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Amato, Ana Paula. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Coduri Anthonioz Blanc, Joaquín Ignacio. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Rottoli, Erwin Alexander. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Protto Baglione, Manuel. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Vicino, Macarena. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Sadonio, María José. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Galluccio, Federico Rafael. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Médicas; Argentina
Fil: Musacchio, Héctor Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Gómez, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Materia
CARBAPENEM RESISTANT
ENTEROBACTERALES
INFECTION CONTROL
RECTAL CARRIAGE
AMR
DIAGNOSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/276103
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/276103
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series studyCastro, Maximiliano GabrielArgarañá, María FernandaBernasconi, CarlaMargenet, Leticia ElenaAmato, Ana PaulaCoduri Anthonioz Blanc, Joaquín IgnacioRottoli, Erwin AlexanderProtto Baglione, ManuelVicino, MacarenaSadonio, María JoséGalluccio, Federico RafaelMusacchio, Héctor MarioPasteran, FernandoGómez, Sonia AlejandraCARBAPENEM RESISTANTENTEROBACTERALESINFECTION CONTROLRECTAL CARRIAGEAMRDIAGNOSIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: The spread of carbapenemase-producing bacteria (CPB) isexacerbated in hospital settings, making the surveillance of rectal carriage ofCPB crucial to halt their spread. However, the processing time until detectionwith traditional methods and the cost of new techniques limit theirimplementation. We aimed to evaluate the effectiveness of infectionprevention and control (IPC) measures guided by a novel algorithm (NA) forrectal swab processing, which incorporated a modified Blue-Carba test (mBCT),in reducing carbapenemase-producing bacteria (CPB) rectal carriage prevalencein general wards of a tertiary-care hospital from Argentina. Additionally, weassessed the impact of this algorithm on microbiological turnaround time(mTAT) and time to positive results (TPR).Materials and methods: An experimental and quasi-experimental designs werecombined into a prospective interrupted time series study structured in threephases: P1 (February 2022-July 2022), P2 (August 2022-January 2023;intervention) and P3 (February 2023-July 2023). Briefly, the NA included askey steps a 6-hour pre-incubation at 37 °C in nutrient broth, followed by a15-minute centrifugation at 3,200 rpm. The mBCT was set at pH 10.7 using 9 mgof imipenem in a final volume of 150 μL and was validated against conventionalmethods testing 1,120 samples. It was subsequently implemented to assess itsimpact on hospital CPB prevalence and the effectiveness of IPC measures. Patientswere randomly selected for CPB rectal screening during Phases 1 and 3 andprovided informed consent for inclusion.Results: The mBCT significantly shortened the mTAT and TPR compared tostandard approaches (<24 h vs. 4d, p < 0.001), showing moderate sensitivity[54.6% (IC95% 45.2–63.7)] and high specificity [99.8% (IC 95% 99.3–100)]. TheIPC intervention guided by the mBCT reduced CPB prevalence in general wards(8.1% vs. 13.8%, p = 0.006).Conclusion: The implementation of the NA reduced mTAT with high sensitivity,while the mBCT also contributed to reducing TPR with high specificity. Integratingthe NA and mBCT into IPC protocols led to a decrease in CPB rectal carriageprevalence in general wards, underscoring their diagnostic, epidemiological andthus IPC benefits.Fil: Castro, Maximiliano Gabriel. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Médicas; ArgentinaFil: Argarañá, María Fernanda. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; ArgentinaFil: Bernasconi, Carla. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; ArgentinaFil: Margenet, Leticia Elena. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; ArgentinaFil: Amato, Ana Paula. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; ArgentinaFil: Coduri Anthonioz Blanc, Joaquín Ignacio. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; ArgentinaFil: Rottoli, Erwin Alexander. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; ArgentinaFil: Protto Baglione, Manuel. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; ArgentinaFil: Vicino, Macarena. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; ArgentinaFil: Sadonio, María José. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; ArgentinaFil: Galluccio, Federico Rafael. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Médicas; ArgentinaFil: Musacchio, Héctor Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; ArgentinaFil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Gómez, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFrontiers Media2025-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/276103Castro, Maximiliano Gabriel; Argarañá, María Fernanda; Bernasconi, Carla; Margenet, Leticia Elena; Amato, Ana Paula; et al.; Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study; Frontiers Media; Frontiers in Pharmacology; 16; 9-2025; 1-141663-9812CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphar.2025.1584646/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2025.1584646info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-03T09:37:54Zoai:ri.conicet.gov.ar:11336/276103instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-03 09:37:55.227CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study
title Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study
spellingShingle Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study
Castro, Maximiliano Gabriel
CARBAPENEM RESISTANT
ENTEROBACTERALES
INFECTION CONTROL
RECTAL CARRIAGE
AMR
DIAGNOSIS
title_short Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study
title_full Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study
title_fullStr Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study
title_full_unstemmed Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study
title_sort Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study
dc.creator.none.fl_str_mv Castro, Maximiliano Gabriel
Argarañá, María Fernanda
Bernasconi, Carla
Margenet, Leticia Elena
Amato, Ana Paula
Coduri Anthonioz Blanc, Joaquín Ignacio
Rottoli, Erwin Alexander
Protto Baglione, Manuel
Vicino, Macarena
Sadonio, María José
Galluccio, Federico Rafael
Musacchio, Héctor Mario
Pasteran, Fernando
Gómez, Sonia Alejandra
author Castro, Maximiliano Gabriel
author_facet Castro, Maximiliano Gabriel
Argarañá, María Fernanda
Bernasconi, Carla
Margenet, Leticia Elena
Amato, Ana Paula
Coduri Anthonioz Blanc, Joaquín Ignacio
Rottoli, Erwin Alexander
Protto Baglione, Manuel
Vicino, Macarena
Sadonio, María José
Galluccio, Federico Rafael
Musacchio, Héctor Mario
Pasteran, Fernando
Gómez, Sonia Alejandra
author_role author
author2 Argarañá, María Fernanda
Bernasconi, Carla
Margenet, Leticia Elena
Amato, Ana Paula
Coduri Anthonioz Blanc, Joaquín Ignacio
Rottoli, Erwin Alexander
Protto Baglione, Manuel
Vicino, Macarena
Sadonio, María José
Galluccio, Federico Rafael
Musacchio, Héctor Mario
Pasteran, Fernando
Gómez, Sonia Alejandra
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CARBAPENEM RESISTANT
ENTEROBACTERALES
INFECTION CONTROL
RECTAL CARRIAGE
AMR
DIAGNOSIS
topic CARBAPENEM RESISTANT
ENTEROBACTERALES
INFECTION CONTROL
RECTAL CARRIAGE
AMR
DIAGNOSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: The spread of carbapenemase-producing bacteria (CPB) isexacerbated in hospital settings, making the surveillance of rectal carriage ofCPB crucial to halt their spread. However, the processing time until detectionwith traditional methods and the cost of new techniques limit theirimplementation. We aimed to evaluate the effectiveness of infectionprevention and control (IPC) measures guided by a novel algorithm (NA) forrectal swab processing, which incorporated a modified Blue-Carba test (mBCT),in reducing carbapenemase-producing bacteria (CPB) rectal carriage prevalencein general wards of a tertiary-care hospital from Argentina. Additionally, weassessed the impact of this algorithm on microbiological turnaround time(mTAT) and time to positive results (TPR).Materials and methods: An experimental and quasi-experimental designs werecombined into a prospective interrupted time series study structured in threephases: P1 (February 2022-July 2022), P2 (August 2022-January 2023;intervention) and P3 (February 2023-July 2023). Briefly, the NA included askey steps a 6-hour pre-incubation at 37 °C in nutrient broth, followed by a15-minute centrifugation at 3,200 rpm. The mBCT was set at pH 10.7 using 9 mgof imipenem in a final volume of 150 μL and was validated against conventionalmethods testing 1,120 samples. It was subsequently implemented to assess itsimpact on hospital CPB prevalence and the effectiveness of IPC measures. Patientswere randomly selected for CPB rectal screening during Phases 1 and 3 andprovided informed consent for inclusion.Results: The mBCT significantly shortened the mTAT and TPR compared tostandard approaches (<24 h vs. 4d, p < 0.001), showing moderate sensitivity[54.6% (IC95% 45.2–63.7)] and high specificity [99.8% (IC 95% 99.3–100)]. TheIPC intervention guided by the mBCT reduced CPB prevalence in general wards(8.1% vs. 13.8%, p = 0.006).Conclusion: The implementation of the NA reduced mTAT with high sensitivity,while the mBCT also contributed to reducing TPR with high specificity. Integratingthe NA and mBCT into IPC protocols led to a decrease in CPB rectal carriageprevalence in general wards, underscoring their diagnostic, epidemiological andthus IPC benefits.
Fil: Castro, Maximiliano Gabriel. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Médicas; Argentina
Fil: Argarañá, María Fernanda. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentina
Fil: Bernasconi, Carla. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Margenet, Leticia Elena. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Amato, Ana Paula. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Coduri Anthonioz Blanc, Joaquín Ignacio. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Rottoli, Erwin Alexander. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Protto Baglione, Manuel. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Vicino, Macarena. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Sadonio, María José. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Galluccio, Federico Rafael. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina. Universidad Nacional del Litoral. Facultad de Ciencias Médicas; Argentina
Fil: Musacchio, Héctor Mario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Santa Fe. Ministerio de Salud. Hospital J. B. Iturraspe; Argentina
Fil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
Fil: Gómez, Sonia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; Argentina
description Introduction: The spread of carbapenemase-producing bacteria (CPB) isexacerbated in hospital settings, making the surveillance of rectal carriage ofCPB crucial to halt their spread. However, the processing time until detectionwith traditional methods and the cost of new techniques limit theirimplementation. We aimed to evaluate the effectiveness of infectionprevention and control (IPC) measures guided by a novel algorithm (NA) forrectal swab processing, which incorporated a modified Blue-Carba test (mBCT),in reducing carbapenemase-producing bacteria (CPB) rectal carriage prevalencein general wards of a tertiary-care hospital from Argentina. Additionally, weassessed the impact of this algorithm on microbiological turnaround time(mTAT) and time to positive results (TPR).Materials and methods: An experimental and quasi-experimental designs werecombined into a prospective interrupted time series study structured in threephases: P1 (February 2022-July 2022), P2 (August 2022-January 2023;intervention) and P3 (February 2023-July 2023). Briefly, the NA included askey steps a 6-hour pre-incubation at 37 °C in nutrient broth, followed by a15-minute centrifugation at 3,200 rpm. The mBCT was set at pH 10.7 using 9 mgof imipenem in a final volume of 150 μL and was validated against conventionalmethods testing 1,120 samples. It was subsequently implemented to assess itsimpact on hospital CPB prevalence and the effectiveness of IPC measures. Patientswere randomly selected for CPB rectal screening during Phases 1 and 3 andprovided informed consent for inclusion.Results: The mBCT significantly shortened the mTAT and TPR compared tostandard approaches (<24 h vs. 4d, p < 0.001), showing moderate sensitivity[54.6% (IC95% 45.2–63.7)] and high specificity [99.8% (IC 95% 99.3–100)]. TheIPC intervention guided by the mBCT reduced CPB prevalence in general wards(8.1% vs. 13.8%, p = 0.006).Conclusion: The implementation of the NA reduced mTAT with high sensitivity,while the mBCT also contributed to reducing TPR with high specificity. Integratingthe NA and mBCT into IPC protocols led to a decrease in CPB rectal carriageprevalence in general wards, underscoring their diagnostic, epidemiological andthus IPC benefits.
publishDate 2025
dc.date.none.fl_str_mv 2025-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/276103
Castro, Maximiliano Gabriel; Argarañá, María Fernanda; Bernasconi, Carla; Margenet, Leticia Elena; Amato, Ana Paula; et al.; Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study; Frontiers Media; Frontiers in Pharmacology; 16; 9-2025; 1-14
1663-9812
CONICET Digital
CONICET
url http://hdl.handle.net/11336/276103
identifier_str_mv Castro, Maximiliano Gabriel; Argarañá, María Fernanda; Bernasconi, Carla; Margenet, Leticia Elena; Amato, Ana Paula; et al.; Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards: a prospective interrupted time series study; Frontiers Media; Frontiers in Pharmacology; 16; 9-2025; 1-14
1663-9812
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.3389/fphar.2025.1584646
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
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dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.227901

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