DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia

Autores
Etulain, Julia; Oneto, Paula; Landro, M.E.; Daffunchio, C.; Price, A. L. D.; Schattner, Mirta Ana; Caviglia, H.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Background and aims: Hemarthroses cause major morbidity in hemophilia resulting in chronic hemophilic synovitis (CHS), osteochondral degeneration and arthropathy. Although the initial events causing joint damage remain uncertain, iron and monocytes-induced inflammation are known players in this process. The role of neutrophils, major immune blood cells infiltrated in synovium after bleeding is unknown. Neutrophils release extracellular DNA traps (NETs), microbicides structures containing DNA fibers with bound granular enzymes as elastase. During chronic inflammation, a cytotoxic effect of NETs has been associated with tissue damage in lung, kidney, skin and joints. Our aim is to elucidate the role of neutrophils in CHS by studying the formation of synovial NETs and its correlation with joint damage....
Fil: Etulain, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Oneto, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Landro, M.E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Daffunchio, C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Price, A. L. D.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Caviglia, H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
16th International Musculoskeletal Congress
Madrid
España
World Federation Haemophilia
Materia
DNA
NEUTROPHIL EXTRACELULAR TRAP
HEMOPHILIA
PRP
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/130722
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In HemophiliaEtulain, JuliaOneto, PaulaLandro, M.E.Daffunchio, C.Price, A. L. D.Schattner, Mirta AnaCaviglia, H.DNANEUTROPHIL EXTRACELULAR TRAPHEMOPHILIAPRPhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background and aims: Hemarthroses cause major morbidity in hemophilia resulting in chronic hemophilic synovitis (CHS), osteochondral degeneration and arthropathy. Although the initial events causing joint damage remain uncertain, iron and monocytes-induced inflammation are known players in this process. The role of neutrophils, major immune blood cells infiltrated in synovium after bleeding is unknown. Neutrophils release extracellular DNA traps (NETs), microbicides structures containing DNA fibers with bound granular enzymes as elastase. During chronic inflammation, a cytotoxic effect of NETs has been associated with tissue damage in lung, kidney, skin and joints. Our aim is to elucidate the role of neutrophils in CHS by studying the formation of synovial NETs and its correlation with joint damage....Fil: Etulain, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Oneto, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Landro, M.E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Daffunchio, C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Price, A. L. D.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; ArgentinaFil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Caviglia, H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina16th International Musculoskeletal CongressMadridEspañaWorld Federation HaemophiliaWiley2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/130722DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia; 16th International Musculoskeletal Congress; Madrid; España; 2019; 1-21351-8216CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/toc/13652516/25/S3Internacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:56:57Zoai:ri.conicet.gov.ar:11336/130722instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:56:57.989CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia
title DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia
spellingShingle DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia
Etulain, Julia
DNA
NEUTROPHIL EXTRACELULAR TRAP
HEMOPHILIA
PRP
title_short DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia
title_full DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia
title_fullStr DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia
title_full_unstemmed DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia
title_sort DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia
dc.creator.none.fl_str_mv Etulain, Julia
Oneto, Paula
Landro, M.E.
Daffunchio, C.
Price, A. L. D.
Schattner, Mirta Ana
Caviglia, H.
author Etulain, Julia
author_facet Etulain, Julia
Oneto, Paula
Landro, M.E.
Daffunchio, C.
Price, A. L. D.
Schattner, Mirta Ana
Caviglia, H.
author_role author
author2 Oneto, Paula
Landro, M.E.
Daffunchio, C.
Price, A. L. D.
Schattner, Mirta Ana
Caviglia, H.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv DNA
NEUTROPHIL EXTRACELULAR TRAP
HEMOPHILIA
PRP
topic DNA
NEUTROPHIL EXTRACELULAR TRAP
HEMOPHILIA
PRP
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background and aims: Hemarthroses cause major morbidity in hemophilia resulting in chronic hemophilic synovitis (CHS), osteochondral degeneration and arthropathy. Although the initial events causing joint damage remain uncertain, iron and monocytes-induced inflammation are known players in this process. The role of neutrophils, major immune blood cells infiltrated in synovium after bleeding is unknown. Neutrophils release extracellular DNA traps (NETs), microbicides structures containing DNA fibers with bound granular enzymes as elastase. During chronic inflammation, a cytotoxic effect of NETs has been associated with tissue damage in lung, kidney, skin and joints. Our aim is to elucidate the role of neutrophils in CHS by studying the formation of synovial NETs and its correlation with joint damage....
Fil: Etulain, Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Oneto, Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Landro, M.E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Daffunchio, C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Price, A. L. D.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
Fil: Schattner, Mirta Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Caviglia, H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Juan A. Fernández"; Argentina
16th International Musculoskeletal Congress
Madrid
España
World Federation Haemophilia
description Background and aims: Hemarthroses cause major morbidity in hemophilia resulting in chronic hemophilic synovitis (CHS), osteochondral degeneration and arthropathy. Although the initial events causing joint damage remain uncertain, iron and monocytes-induced inflammation are known players in this process. The role of neutrophils, major immune blood cells infiltrated in synovium after bleeding is unknown. Neutrophils release extracellular DNA traps (NETs), microbicides structures containing DNA fibers with bound granular enzymes as elastase. During chronic inflammation, a cytotoxic effect of NETs has been associated with tissue damage in lung, kidney, skin and joints. Our aim is to elucidate the role of neutrophils in CHS by studying the formation of synovial NETs and its correlation with joint damage....
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Congreso
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/130722
DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia; 16th International Musculoskeletal Congress; Madrid; España; 2019; 1-2
1351-8216
CONICET Digital
CONICET
url http://hdl.handle.net/11336/130722
identifier_str_mv DNA and neutrophil extracellular traps release, novel potential biomarkers and therapeutic targets of joint Damage In Hemophilia; 16th International Musculoskeletal Congress; Madrid; España; 2019; 1-2
1351-8216
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/toc/13652516/25/S3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/msword
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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