Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits
- Autores
- Medina, María Fernanda; Alberto, Maria Rosa; Sierra, Liliana; Van Nieuwenhove, Carina Paola; Saad, Silvia; Isla, Maria Ines; Jerez, Susana Josefina
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The present study evaluatedthe plasma fatty acidlevels and thevascular prostaglandin releaseina rabbit model of early hypercholesterolemia with endothelial dysfunction. Rabbits were fed either a control diet (CD) or a diet containing 1 % cholesterol (HD) for 5-6 weeks. The level of fatty acids was measured in plasma. The levels of prostaglandin and nitric oxide (NO) released from aorta were also determined. Vascular morphology of aorta was characterized by intima and media thickness measurement. The rabbits fed with HD had higher levels of arachidonic acid (ARA) and lower levels of oleic acid (OLA). Linoleic acid (LNA) level was unchanged. PGI2 and NO were diminished and PGF2αlevels, the PGI2/TXA2 ratio and the intima/media ratio were increased in rabbits fed with HD. In conclusion, feeding a HD for a short period increased ARA plasma levels and unbalanced release of vasodilator/vasoconstrictor PG redirecting the pathway to vasoconstrictor metabolite release. These lipid metabolism alterations in addition to the reduced NO levels and the moderate changes in the vascular morphology would contribute to the endothelial dysfunction in this animal model. Therefore, the present findings support the importance ofearly correction or prevention of high cholesterol levels to disruptthe endothelial dysfunction processthat leadsto cardiovascular disease.
Fil: Medina, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Química del Noroeste. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Sierra, Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina
Fil: Van Nieuwenhove, Carina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Saad, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina
Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Química del Noroeste. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina - Materia
-
Hypercholesterolemia
Arachidonic Acid
Prostaglandins
Rabbit Aorta
Endothelial Dysfunction
Fatty Acids - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/19420
Ver los metadatos del registro completo
id |
CONICETDig_8198b92125c0dc9886229f1423083fcf |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/19420 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbitsMedina, María FernandaAlberto, Maria RosaSierra, LilianaVan Nieuwenhove, Carina PaolaSaad, SilviaIsla, Maria InesJerez, Susana JosefinaHypercholesterolemiaArachidonic AcidProstaglandinsRabbit AortaEndothelial DysfunctionFatty Acidshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The present study evaluatedthe plasma fatty acidlevels and thevascular prostaglandin releaseina rabbit model of early hypercholesterolemia with endothelial dysfunction. Rabbits were fed either a control diet (CD) or a diet containing 1 % cholesterol (HD) for 5-6 weeks. The level of fatty acids was measured in plasma. The levels of prostaglandin and nitric oxide (NO) released from aorta were also determined. Vascular morphology of aorta was characterized by intima and media thickness measurement. The rabbits fed with HD had higher levels of arachidonic acid (ARA) and lower levels of oleic acid (OLA). Linoleic acid (LNA) level was unchanged. PGI2 and NO were diminished and PGF2αlevels, the PGI2/TXA2 ratio and the intima/media ratio were increased in rabbits fed with HD. In conclusion, feeding a HD for a short period increased ARA plasma levels and unbalanced release of vasodilator/vasoconstrictor PG redirecting the pathway to vasoconstrictor metabolite release. These lipid metabolism alterations in addition to the reduced NO levels and the moderate changes in the vascular morphology would contribute to the endothelial dysfunction in this animal model. Therefore, the present findings support the importance ofearly correction or prevention of high cholesterol levels to disruptthe endothelial dysfunction processthat leadsto cardiovascular disease.Fil: Medina, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Química del Noroeste. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Sierra, Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; ArgentinaFil: Van Nieuwenhove, Carina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Saad, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; ArgentinaFil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Química del Noroeste. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; ArgentinaSpringer2014-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://dx.doi.org/10.1007/s11745-014-3915-6https://link.springer.com/article/10.1007/s11745-014-3915-6http://hdl.handle.net/11336/19420Medina, María Fernanda; Alberto, Maria Rosa; Sierra, Liliana; Van Nieuwenhove, Carina Paola; Saad, Silvia; et al.; Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits; Springer; Lipids; 49; 7; 7-2014; 685-6930024-42011558-9307enginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s11745-014-3915-6info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s11745-014-3915-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:16Zoai:ri.conicet.gov.ar:11336/19420instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:16.566CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits |
title |
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits |
spellingShingle |
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits Medina, María Fernanda Hypercholesterolemia Arachidonic Acid Prostaglandins Rabbit Aorta Endothelial Dysfunction Fatty Acids |
title_short |
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits |
title_full |
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits |
title_fullStr |
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits |
title_full_unstemmed |
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits |
title_sort |
Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits |
dc.creator.none.fl_str_mv |
Medina, María Fernanda Alberto, Maria Rosa Sierra, Liliana Van Nieuwenhove, Carina Paola Saad, Silvia Isla, Maria Ines Jerez, Susana Josefina |
author |
Medina, María Fernanda |
author_facet |
Medina, María Fernanda Alberto, Maria Rosa Sierra, Liliana Van Nieuwenhove, Carina Paola Saad, Silvia Isla, Maria Ines Jerez, Susana Josefina |
author_role |
author |
author2 |
Alberto, Maria Rosa Sierra, Liliana Van Nieuwenhove, Carina Paola Saad, Silvia Isla, Maria Ines Jerez, Susana Josefina |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
Hypercholesterolemia Arachidonic Acid Prostaglandins Rabbit Aorta Endothelial Dysfunction Fatty Acids |
topic |
Hypercholesterolemia Arachidonic Acid Prostaglandins Rabbit Aorta Endothelial Dysfunction Fatty Acids |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The present study evaluatedthe plasma fatty acidlevels and thevascular prostaglandin releaseina rabbit model of early hypercholesterolemia with endothelial dysfunction. Rabbits were fed either a control diet (CD) or a diet containing 1 % cholesterol (HD) for 5-6 weeks. The level of fatty acids was measured in plasma. The levels of prostaglandin and nitric oxide (NO) released from aorta were also determined. Vascular morphology of aorta was characterized by intima and media thickness measurement. The rabbits fed with HD had higher levels of arachidonic acid (ARA) and lower levels of oleic acid (OLA). Linoleic acid (LNA) level was unchanged. PGI2 and NO were diminished and PGF2αlevels, the PGI2/TXA2 ratio and the intima/media ratio were increased in rabbits fed with HD. In conclusion, feeding a HD for a short period increased ARA plasma levels and unbalanced release of vasodilator/vasoconstrictor PG redirecting the pathway to vasoconstrictor metabolite release. These lipid metabolism alterations in addition to the reduced NO levels and the moderate changes in the vascular morphology would contribute to the endothelial dysfunction in this animal model. Therefore, the present findings support the importance ofearly correction or prevention of high cholesterol levels to disruptthe endothelial dysfunction processthat leadsto cardiovascular disease. Fil: Medina, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Química del Noroeste. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina Fil: Sierra, Liliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina Fil: Van Nieuwenhove, Carina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina Fil: Saad, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto de Química del Noroeste. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina Fil: Jerez, Susana Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucuman. Instituto Superior de Investigaciones Biologicas; Argentina |
description |
The present study evaluatedthe plasma fatty acidlevels and thevascular prostaglandin releaseina rabbit model of early hypercholesterolemia with endothelial dysfunction. Rabbits were fed either a control diet (CD) or a diet containing 1 % cholesterol (HD) for 5-6 weeks. The level of fatty acids was measured in plasma. The levels of prostaglandin and nitric oxide (NO) released from aorta were also determined. Vascular morphology of aorta was characterized by intima and media thickness measurement. The rabbits fed with HD had higher levels of arachidonic acid (ARA) and lower levels of oleic acid (OLA). Linoleic acid (LNA) level was unchanged. PGI2 and NO were diminished and PGF2αlevels, the PGI2/TXA2 ratio and the intima/media ratio were increased in rabbits fed with HD. In conclusion, feeding a HD for a short period increased ARA plasma levels and unbalanced release of vasodilator/vasoconstrictor PG redirecting the pathway to vasoconstrictor metabolite release. These lipid metabolism alterations in addition to the reduced NO levels and the moderate changes in the vascular morphology would contribute to the endothelial dysfunction in this animal model. Therefore, the present findings support the importance ofearly correction or prevention of high cholesterol levels to disruptthe endothelial dysfunction processthat leadsto cardiovascular disease. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://dx.doi.org/10.1007/s11745-014-3915-6 https://link.springer.com/article/10.1007/s11745-014-3915-6 http://hdl.handle.net/11336/19420 Medina, María Fernanda; Alberto, Maria Rosa; Sierra, Liliana; Van Nieuwenhove, Carina Paola; Saad, Silvia; et al.; Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits; Springer; Lipids; 49; 7; 7-2014; 685-693 0024-4201 1558-9307 |
url |
http://dx.doi.org/10.1007/s11745-014-3915-6 https://link.springer.com/article/10.1007/s11745-014-3915-6 http://hdl.handle.net/11336/19420 |
identifier_str_mv |
Medina, María Fernanda; Alberto, Maria Rosa; Sierra, Liliana; Van Nieuwenhove, Carina Paola; Saad, Silvia; et al.; Hypercholesterolemia increases plasma saturated and n-6 fatty acids altering prostaglandin homeostasis and promotes endothelial dysfunction in rabbits; Springer; Lipids; 49; 7; 7-2014; 685-693 0024-4201 1558-9307 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11745-014-3915-6 info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s11745-014-3915-6 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269629214359552 |
score |
13.13397 |