Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis

Autores
Sabatini, Sebastian Eduardo; Rocchetta, Iara; Nahabedian, Daniel Eduardo; Luquet, Carlos Marcelo; Eppis, Maria Rosa; Bianchi, Laura; Rios, Maria del Carmen
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to study the oxidative stress effects and histological alterations caused by dietary copper on the filter-feeding freshwater mussel Diplodon chilensis. Bivalves were fed during 6 weeks with the green algae Scenedesmus vacuolatus previously exposed to copper. Metal concentration in algae cultures and bivalve digestive gland was measured by TXRF. A maximum accumulation of 0.49 μg Cu/mg protein was detected at week 6. Also at this week, the hepatosomatic index (HSI) showed the highest decrease (50%) in response to Cu exposure. SOD and GST activities were significantly increased at weeks 4, 5 and 6, reaching an activity on average 50% higher than in controls for GST. CAT activity and GSH increased significantly at weeks 5 and 6. Despite this response, oxidative damage measured as TBARS and carbonyl groups contents increased significantly at weeks 4, 5 and 6, respectively. Digestive tubule and duct atrophy and cell-type replacement in treated mussels were observed by histological studies. The presence of intracellular rhodanine-positive granules, suggests copper accumulation in intracellular vacuoles of digestive cells. © 2011 Elsevier Inc. All rights reserved.
Fil: Sabatini, Sebastian Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Rocchetta, Iara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Nahabedian, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Luquet, Carlos Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina
Fil: Eppis, Maria Rosa. Comisión Nacional de Energía Atómica; Argentina
Fil: Bianchi, Laura. Comisión Nacional de Energía Atómica; Argentina
Fil: Rios, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Materia
Antioxidant Defenses
Dietary Copper
Diplodon Chilensis
Metal Bioaccumulation
Oxidative Stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64847

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network_name_str CONICET Digital (CONICET)
spelling Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensisSabatini, Sebastian EduardoRocchetta, IaraNahabedian, Daniel EduardoLuquet, Carlos MarceloEppis, Maria RosaBianchi, LauraRios, Maria del CarmenAntioxidant DefensesDietary CopperDiplodon ChilensisMetal BioaccumulationOxidative Stresshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The aim of this work was to study the oxidative stress effects and histological alterations caused by dietary copper on the filter-feeding freshwater mussel Diplodon chilensis. Bivalves were fed during 6 weeks with the green algae Scenedesmus vacuolatus previously exposed to copper. Metal concentration in algae cultures and bivalve digestive gland was measured by TXRF. A maximum accumulation of 0.49 μg Cu/mg protein was detected at week 6. Also at this week, the hepatosomatic index (HSI) showed the highest decrease (50%) in response to Cu exposure. SOD and GST activities were significantly increased at weeks 4, 5 and 6, reaching an activity on average 50% higher than in controls for GST. CAT activity and GSH increased significantly at weeks 5 and 6. Despite this response, oxidative damage measured as TBARS and carbonyl groups contents increased significantly at weeks 4, 5 and 6, respectively. Digestive tubule and duct atrophy and cell-type replacement in treated mussels were observed by histological studies. The presence of intracellular rhodanine-positive granules, suggests copper accumulation in intracellular vacuoles of digestive cells. © 2011 Elsevier Inc. All rights reserved.Fil: Sabatini, Sebastian Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; ArgentinaFil: Rocchetta, Iara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Nahabedian, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; ArgentinaFil: Luquet, Carlos Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; ArgentinaFil: Eppis, Maria Rosa. Comisión Nacional de Energía Atómica; ArgentinaFil: Bianchi, Laura. Comisión Nacional de Energía Atómica; ArgentinaFil: Rios, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaElsevier Science Inc2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64847Sabatini, Sebastian Eduardo; Rocchetta, Iara; Nahabedian, Daniel Eduardo; Luquet, Carlos Marcelo; Eppis, Maria Rosa; et al.; Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis; Elsevier Science Inc; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 154; 4; 11-2011; 391-3981532-0456CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbpc.2011.07.009info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1532045611001463info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:59Zoai:ri.conicet.gov.ar:11336/64847instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:59.933CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
title Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
spellingShingle Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
Sabatini, Sebastian Eduardo
Antioxidant Defenses
Dietary Copper
Diplodon Chilensis
Metal Bioaccumulation
Oxidative Stress
title_short Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
title_full Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
title_fullStr Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
title_full_unstemmed Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
title_sort Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis
dc.creator.none.fl_str_mv Sabatini, Sebastian Eduardo
Rocchetta, Iara
Nahabedian, Daniel Eduardo
Luquet, Carlos Marcelo
Eppis, Maria Rosa
Bianchi, Laura
Rios, Maria del Carmen
author Sabatini, Sebastian Eduardo
author_facet Sabatini, Sebastian Eduardo
Rocchetta, Iara
Nahabedian, Daniel Eduardo
Luquet, Carlos Marcelo
Eppis, Maria Rosa
Bianchi, Laura
Rios, Maria del Carmen
author_role author
author2 Rocchetta, Iara
Nahabedian, Daniel Eduardo
Luquet, Carlos Marcelo
Eppis, Maria Rosa
Bianchi, Laura
Rios, Maria del Carmen
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Antioxidant Defenses
Dietary Copper
Diplodon Chilensis
Metal Bioaccumulation
Oxidative Stress
topic Antioxidant Defenses
Dietary Copper
Diplodon Chilensis
Metal Bioaccumulation
Oxidative Stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The aim of this work was to study the oxidative stress effects and histological alterations caused by dietary copper on the filter-feeding freshwater mussel Diplodon chilensis. Bivalves were fed during 6 weeks with the green algae Scenedesmus vacuolatus previously exposed to copper. Metal concentration in algae cultures and bivalve digestive gland was measured by TXRF. A maximum accumulation of 0.49 μg Cu/mg protein was detected at week 6. Also at this week, the hepatosomatic index (HSI) showed the highest decrease (50%) in response to Cu exposure. SOD and GST activities were significantly increased at weeks 4, 5 and 6, reaching an activity on average 50% higher than in controls for GST. CAT activity and GSH increased significantly at weeks 5 and 6. Despite this response, oxidative damage measured as TBARS and carbonyl groups contents increased significantly at weeks 4, 5 and 6, respectively. Digestive tubule and duct atrophy and cell-type replacement in treated mussels were observed by histological studies. The presence of intracellular rhodanine-positive granules, suggests copper accumulation in intracellular vacuoles of digestive cells. © 2011 Elsevier Inc. All rights reserved.
Fil: Sabatini, Sebastian Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Rocchetta, Iara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Fil: Nahabedian, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Luquet, Carlos Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentina
Fil: Eppis, Maria Rosa. Comisión Nacional de Energía Atómica; Argentina
Fil: Bianchi, Laura. Comisión Nacional de Energía Atómica; Argentina
Fil: Rios, Maria del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
description The aim of this work was to study the oxidative stress effects and histological alterations caused by dietary copper on the filter-feeding freshwater mussel Diplodon chilensis. Bivalves were fed during 6 weeks with the green algae Scenedesmus vacuolatus previously exposed to copper. Metal concentration in algae cultures and bivalve digestive gland was measured by TXRF. A maximum accumulation of 0.49 μg Cu/mg protein was detected at week 6. Also at this week, the hepatosomatic index (HSI) showed the highest decrease (50%) in response to Cu exposure. SOD and GST activities were significantly increased at weeks 4, 5 and 6, reaching an activity on average 50% higher than in controls for GST. CAT activity and GSH increased significantly at weeks 5 and 6. Despite this response, oxidative damage measured as TBARS and carbonyl groups contents increased significantly at weeks 4, 5 and 6, respectively. Digestive tubule and duct atrophy and cell-type replacement in treated mussels were observed by histological studies. The presence of intracellular rhodanine-positive granules, suggests copper accumulation in intracellular vacuoles of digestive cells. © 2011 Elsevier Inc. All rights reserved.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64847
Sabatini, Sebastian Eduardo; Rocchetta, Iara; Nahabedian, Daniel Eduardo; Luquet, Carlos Marcelo; Eppis, Maria Rosa; et al.; Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis; Elsevier Science Inc; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 154; 4; 11-2011; 391-398
1532-0456
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64847
identifier_str_mv Sabatini, Sebastian Eduardo; Rocchetta, Iara; Nahabedian, Daniel Eduardo; Luquet, Carlos Marcelo; Eppis, Maria Rosa; et al.; Oxidative stress and histological alterations produced by dietary copper in the fresh water bivalve Diplodon chilensis; Elsevier Science Inc; Comparative Biochemistry And Physiology. Toxicology & Pharmacology; 154; 4; 11-2011; 391-398
1532-0456
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cbpc.2011.07.009
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1532045611001463
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
application/pdf
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dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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